Dysbiosis in the Gut Microbiota of Patients with Multiple Sclerosis, with a Striking Depletion of Species Belonging to Clostridia XIVa and IV Clusters

The pathogenesis of multiple sclerosis (MS), an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Patients with MS typically present with recurrent episodes of neurological dysfunctions such as blindness, paresis, and sensory disturbances. Studies on experimental aut...

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Vydané v:	PloS one Ročník 10; číslo 9; s. e0137429
Hlavní autori:	Miyake, Sachiko, Kim, Sangwan, Suda, Wataru, Oshima, Kenshiro, Nakamura, Masakazu, Matsuoka, Takako, Chihara, Norio, Tomita, Atsuko, Sato, Wakiro, Kim, Seok-Won, Morita, Hidetoshi, Hattori, Masahira, Yamamura, Takashi
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 14.09.2015 Public Library of Science (PLoS)
Predmet:	Adult Allergies Animal models Autoimmune diseases Bacteria Bacteroidetes - genetics Bacteroidetes - metabolism Bioinformatics Biology Blindness Brain Cell culture Clostridia Clostridium - classification Clostridium - genetics Clostridium - metabolism Clusters Dysbacteriosis Dysbiosis - metabolism Dysbiosis - microbiology Experimental allergic encephalomyelitis Female Gastrointestinal Microbiome High-Throughput Nucleotide Sequencing Humans Immunology Immunoregulation Inflammatory bowel disease Intestinal microflora Japan Lymphocytes Lymphocytes T Male Metabolites Microbiota Multiple sclerosis Multiple Sclerosis - microbiology Multiple Sclerosis - physiopathology Neurological diseases Neurosciences Paresis Pathogenesis Patients Phylogenetics Phylogeny Relative abundance Ribonucleic acid RNA RNA, Bacterial - genetics RNA, Ribosomal, 16S - genetics rRNA 16S Sequence Analysis, RNA Species Spinal cord Womens health Japan
ISSN:	1932-6203, 1932-6203
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