Proline-Hydroxylated Hypoxia-Inducible Factor 1α (HIF-1α) Upregulation in Human Tumours

The stabilisation of HIF-α is central to the transcriptional response of animals to hypoxia, regulating the expression of hundreds of genes including those involved in angiogenesis, metabolism and metastasis. HIF-α is degraded under normoxic conditions by proline hydroxylation, which allows for reco...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 2; p. e88955
Main Authors:	Snell, Cameron E., Turley, Helen, McIntyre, Alan, Li, Demin, Masiero, Massimo, Schofield, Christopher J., Gatter, Kevin C., Harris, Adrian L., Pezzella, Francesco
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 12.02.2014 Public Library of Science (PLoS)
Subjects:	Angiogenesis Animals Antibodies Binding Sites Biology Brain cancer Breast cancer Breast Neoplasms - pathology Cancer Cell Line, Tumor Degradation Female Gene expression Gene Expression Regulation, Neoplastic Humans Hydroxylation Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Immunoglobulins Immunohistochemistry Kaplan-Meier Estimate Laboratories MCF-7 Cells Medical research Medicine Metabolism Metastases Metastasis Mice Mice, Inbred BALB C Neoplasm Transplantation Neoplasms - metabolism Oncology Oxygen Paraffin Pathology Procollagen-Proline Dioxygenase - metabolism Prognosis Proline Proline - metabolism Prolyl hydroxylase Proteins Stability analysis Transcription Tumors Ubiquitin-protein ligase Ubiquitination Up-Regulation VHL protein Xenografts
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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