NF-κB and CREB Are Required for Angiotensin II Type 1 Receptor Upregulation in Neurons

Nuclear factor kappa B (NF-κB) and the Ets like gene-1 (Elk-1) are two transcription factors that have been previously established to contribute to the Angiotensin II mediated upregulation of Angiotensin II type 1 receptor (AT1R) in neurons. The cAMP response element binding protein (CREB) is anothe...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 11; p. e78695
Main Authors:	Haack, Karla K. V., Mitra, Amit K., Zucker, Irving H.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11.11.2013 Public Library of Science (PLoS)
Subjects:	Angiotensin Angiotensin II Angiotensin II - pharmacology Anti-Inflammatory Agents, Non-Steroidal - pharmacology Ca2+/calmodulin-dependent protein kinase Calcium-binding protein Calmodulin Cell Line Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - genetics Cyclic AMP Response Element-Binding Protein - metabolism Deoxyribonucleic acid DNA Electrophoretic mobility Elk ETS protein ets-Domain Protein Elk-1 - genetics ets-Domain Protein Elk-1 - metabolism Gene expression Heart failure Humans Hypertension Imidazoles - pharmacology Inhibition Kinases MAP kinase Metastasis Molecular modelling Neurons NF-kappa B - genetics NF-kappa B - metabolism NF-κB protein p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors p38 Mitogen-Activated Protein Kinases - genetics p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Physiology Proteins Pyridines - pharmacology Receptor, Angiotensin, Type 1 - biosynthesis Receptor, Angiotensin, Type 1 - genetics Renin Rodents Signaling siRNA Smooth muscle Transcription activation Transcription factors Up-regulation Up-Regulation - drug effects Up-Regulation - physiology Vasoconstrictor Agents - pharmacology United States > US Nebraska
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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