Inflammation and Renal Function after a Four-Year Follow-Up in Subjects with Unimpaired Glomerular Filtration Rate: Results from the Observational, Population-Based CARLA Cohort

There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a co...

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Veröffentlicht in:PloS one Jg. 9; H. 9; S. e108427
Hauptverfasser: Medenwald, Daniel, Girndt, Matthias, Loppnow, Harald, Kluttig, Alexander, Nuding, Sebastian, Tiller, Daniel, Thiery, Joachim J., Greiser, Karin H., Haerting, Johannes, Werdan, Karl
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 26.09.2014
Public Library of Science (PLoS)
Schlagworte:
Aged
Aged, 80 and over
Bias
C-reactive protein
C-Reactive Protein - metabolism
Cardiovascular disease
Creatinine
Creatinine - blood
Cross-Sectional Studies
Diabetes
Epidemiology
Epidermal growth factor receptors
Failure
Family medical history
Female
Follow-Up Studies
Gender differences
Geriatrics
Glomerular filtration rate
Glomerular Filtration Rate - physiology
Heart
Humans
Hypertension
Inflammation
Inflammation - blood
Inflammation - physiopathology
Informatics
Interleukin 6
Internal medicine
Kidney - physiopathology
Kidney diseases
Laboratories
Longitudinal Studies
Male
Medical research
Medicine
Medicine and Health Sciences
Middle Aged
Missing data
Older people
Population
Regression analysis
Regression models
Renal failure
Renal function
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - physiopathology
Rodents
Studies
TNF inhibitors
Tumor necrosis factor
Tumor necrosis factor-TNF
Tumors
Values
Womens health
Germany
ISSN:1932-6203, 1932-6203
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Zusammenfassung:There is evidence that chronic inflammation is associated with the progression/development of chronic renal failure; however, relations in subjects with preserved renal function remain insufficiently understood. To examine the association of inflammation with the development of renal failure in a cohort of the elderly general population. After excluding subjects with reduced estimated glomerular filtration rate (eGFR<60 mL/min/1.73 m2) and missing data, the cohort incorporated 785 men and 659 women (aged 45-83 years). Follow-up was performed four years after baseline. Covariate adjusted linear and logistic regression models were used to assess the association of plasma/serum concentrations of soluble tumour necrosis factor receptor 1 (sTNF-R1), C-reactive protein (CRP), and interleukin 6 (IL-6) with change in eGFR/creatinine. The areas under the curve (AUCs) from receiver operating characteristics (ROCs) were estimated. In adjusted models sTNF-R1 was distinctively associated with a decline in eGFR in men (0.6 mL/min/1.73 m2 per 100 pg/mL sTNF-R1; 95% CI: 0.4-0.8), but not in women. A similar association could not be found for CRP or IL-6. Estimates of sTNF-R1 in the cross-sectional analyses were similar between sexes, while CRP and IL-6 were not relevantly associated with eGFR/creatinine. In the elderly male general population with preserved renal function sTNF-R1 predicts the development of renal failure.
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Conceived and designed the experiments: DT AK JH KW KHG JT SN. Performed the experiments: HL JT. Analyzed the data: DM MG. Contributed reagents/materials/analysis tools: DM MG AK DT JH KW HL. Contributed to the writing of the manuscript: DM MG AK DT JH KW. Organized the study: AK DT JH KW SN KHG JT.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0108427