Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype
The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all pu...
Saved in:
| Published in: | PLoS neglected tropical diseases Vol. 14; no. 4; p. e0008264 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
Public Library of Science
01.04.2020
Public Library of Science (PLoS) |
| Subjects: | |
| ISSN: | 1935-2735, 1935-2727, 1935-2735 |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS.
We searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated.
Thirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15-47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93-99), diminished/absent reflexes 96% (95%CI 88-100), sensory symptoms 82% (95%CI 76-88), and facial palsy 51% (95%CI 44-58). Median time between infectious and neurological symptoms was 5-12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables.
The clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959). |
|---|---|
| AbstractList | Background
The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS.
Methods
We searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated.
Results
Thirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15–47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93–99), diminished/absent reflexes 96% (95%CI 88–100), sensory symptoms 82% (95%CI 76–88), and facial palsy 51% (95%CI 44–58). Median time between infectious and neurological symptoms was 5–12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables.
Conclusions
The clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959). Guillain-Barré syndrome (GBS) is a rare but severe neurological disease, characterized by an acute onset flaccid paralysis. GBS is thought to be caused by an exaggerated immune response to common infections that damages the peripheral nerves. The Zika virus (ZIKV) is the most recent pathogen to be connected to GBS, when large outbreaks of ZIKV infection in French Polynesia and Latin America were followed by an increased incidence of GBS patients. To better understand the clinical features and outcome of ZIKV-related GBS, we have performed a systematic review and meta-analysis of all published studies on GBS related to ZIKV. We identified 35 studies, reporting on a total of 601 patients with GBS and a suspected, probable or confirmed Zika virus infection, and were able to summarize data of 587 patients from 21 studies in a pooled analysis. Our study shows that published cases with ZIKV-related GBS generally have both sensory and motor symptoms, facial palsy, demyelination on electrophysiological examination, and a severe disease course that often necessitates ICU admittance. The relatively long time between infectious and neurologic symptoms and the lack of detection of viral particles in bodily fluids in most patients suggest a post-infectious rather than an infectious pathogenesis. However, these results should be interpreted taking into account the heterogeneity between studies, which was considerable for many variables, and a possible reporting bias of more severe cases. Outbreaks of ZIKV and GBS may appear in the future and our study can help clinicians in diagnosing and managing GBS patients in ZIKV endemic areas, and increases our understanding of the neuropathology of ZIKV. The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS. We searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated. Thirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15-47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93-99), diminished/absent reflexes 96% (95%CI 88-100), sensory symptoms 82% (95%CI 76-88), and facial palsy 51% (95%CI 44-58). Median time between infectious and neurological symptoms was 5-12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables. The clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959). Background The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS. Methods We searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated. Results Thirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15–47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93–99), diminished/absent reflexes 96% (95%CI 88–100), sensory symptoms 82% (95%CI 76–88), and facial palsy 51% (95%CI 44–58). Median time between infectious and neurological symptoms was 5–12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables. Conclusions The clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959). The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS.BACKGROUNDThe Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS.We searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated.METHODSWe searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated.Thirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15-47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93-99), diminished/absent reflexes 96% (95%CI 88-100), sensory symptoms 82% (95%CI 76-88), and facial palsy 51% (95%CI 44-58). Median time between infectious and neurological symptoms was 5-12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables.RESULTSThirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15-47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93-99), diminished/absent reflexes 96% (95%CI 88-100), sensory symptoms 82% (95%CI 76-88), and facial palsy 51% (95%CI 44-58). Median time between infectious and neurological symptoms was 5-12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables.The clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959).CONCLUSIONSThe clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959). BackgroundThe Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS.MethodsWe searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated.ResultsThirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15-47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93-99), diminished/absent reflexes 96% (95%CI 88-100), sensory symptoms 82% (95%CI 76-88), and facial palsy 51% (95%CI 44-58). Median time between infectious and neurological symptoms was 5-12 days. Most cases had a demyelinating electrophysiological subtype and half of cases were admitted to the Intensive Care Unit (ICU). Heterogeneity between studies was moderate to substantial for most variables.ConclusionsThe clinical phenotype of GBS associated with ZIKV infection reported in literature is generally a sensorimotor demyelinating GBS with frequent facial palsy and a severe disease course often necessitating ICU admittance. Time between infectious and neurological symptoms and negative PCR in most cases suggests a post-infectious disease mechanism. Heterogeneity between studies was considerable and results may be subject to reporting bias. This study was registered on the international Prospective Register of Systematic Reviews (CRD42018081959). |
| Author | Cunha, Sergio Leonhard, Sonja E. Bresani-Salvi, Cristiane C. Lyra Batista, Joanna D. Brito Ferreira, Maria Lucia Jacobs, Bart C. P. Militão de Albuquerque, Maria de Fatima |
| AuthorAffiliation | 7 NESC Department, Oswaldo Cruz Foundation, Ministry of Health, Recife, Brazil Australian Red Cross Lifelood, AUSTRALIA 1 Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands 3 Medical Sciences College, Federal University of Fronteira Sul, Chapecó, Brazil 6 Department of Neurology, Hospital da Restauração, Recife, Brazil 2 Laboratory of Virology and Experimental Therapy, Oswaldo Cruz Foundation, Ministry of Health, Recife, Brazil 4 Department of Preventive Medicine, Federal University of Pernambuco, Recife, Brazil 5 Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands |
| AuthorAffiliation_xml | – name: 7 NESC Department, Oswaldo Cruz Foundation, Ministry of Health, Recife, Brazil – name: 5 Department of Immunology, Erasmus University Medical Center, Rotterdam, The Netherlands – name: 1 Department of Neurology, Erasmus University Medical Center, Rotterdam, The Netherlands – name: 4 Department of Preventive Medicine, Federal University of Pernambuco, Recife, Brazil – name: 6 Department of Neurology, Hospital da Restauração, Recife, Brazil – name: Australian Red Cross Lifelood, AUSTRALIA – name: 2 Laboratory of Virology and Experimental Therapy, Oswaldo Cruz Foundation, Ministry of Health, Recife, Brazil – name: 3 Medical Sciences College, Federal University of Fronteira Sul, Chapecó, Brazil |
| Author_xml | – sequence: 1 givenname: Sonja E. orcidid: 0000-0003-4832-6926 surname: Leonhard fullname: Leonhard, Sonja E. – sequence: 2 givenname: Cristiane C. surname: Bresani-Salvi fullname: Bresani-Salvi, Cristiane C. – sequence: 3 givenname: Joanna D. surname: Lyra Batista fullname: Lyra Batista, Joanna D. – sequence: 4 givenname: Sergio surname: Cunha fullname: Cunha, Sergio – sequence: 5 givenname: Bart C. surname: Jacobs fullname: Jacobs, Bart C. – sequence: 6 givenname: Maria Lucia surname: Brito Ferreira fullname: Brito Ferreira, Maria Lucia – sequence: 7 givenname: Maria de Fatima surname: P. Militão de Albuquerque fullname: P. Militão de Albuquerque, Maria de Fatima |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32339199$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kktuFDEQhlsoiDzgBggssWHTgx_dPeMskEIEIVIkNrBhY7nt6hkPbrux3YPmHFyALdeAi-F5oSRCrGy5_vrqL1edFkfOOyiKpwRPCJuSV0s_BiftZHBJTzDGM9pUD4oTwlld0imrj27dj4vTGJcY17yekUfFMaOMccL5SfH9ajTWSuPKNzKE3z9RXDsdfA8ogJUJNEoefTZfJFqZMEZkXAcqGe_O0cWvH3EdE_QyGZXlKwPfkHQa9ZBkKbO3dTQR-Q6lBSBljTNK2q0CbIYEPyyywls_3waGBTif1gM8Lh520kZ4sj_Pik_v3n68fF_efLi6vry4KVVNm1RKTYCxGlqisKQVVtB2NatAt1pONa6aiuBKz6iWeIbblrEOg-x43eZH1fGOnRXPd9zB-ij2_xkFrRrMOeMznhXXO4X2cimGYHoZ1sJLI7YPPsyFDLl7C0KqplHTlmcwrhjWM1JxRQmBumIEuiqzXu-rjW0PWoFLQdo70LsRZxZi7ldiSnHNKM2Al3tA8F9HiEn0JirI03Pgx-yb8To7p_Wm1ot70n939-y2o79WDtuRBec7gQo-xgCdUCbJzfSzQWMFwWKzige42Kyi2K9iTq7uJR_4_037A7Pc7Ac |
| CitedBy_id | crossref_primary_10_1371_journal_pntd_0009575 crossref_primary_10_1016_j_ebiom_2023_104457 crossref_primary_10_1093_emph_eoae020 crossref_primary_10_1542_peds_2024_067552 crossref_primary_10_7759_cureus_80960 crossref_primary_10_1212_NXI_0000000000000952 crossref_primary_10_3389_fimmu_2021_750365 crossref_primary_10_1177_02841851221138557 crossref_primary_10_1111_ene_14543 crossref_primary_10_3390_cells10082134 crossref_primary_10_1080_16549716_2021_2008139 crossref_primary_10_1186_s12985_024_02547_z crossref_primary_10_1016_j_ijmmb_2024_100697 crossref_primary_10_1016_j_crpvbd_2025_100251 crossref_primary_10_1111_ene_16094 crossref_primary_10_1186_s10020_021_00422_z crossref_primary_10_1371_journal_pntd_0009516 crossref_primary_10_3390_pathogens11070818 crossref_primary_10_1016_j_jns_2020_117272 crossref_primary_10_1016_j_mehy_2021_110685 crossref_primary_10_1017_S0950268822001625 crossref_primary_10_3390_pathogens12121457 crossref_primary_10_1186_s12982_025_00682_8 crossref_primary_10_1111_jns_12469 crossref_primary_10_1002_cbdv_202300192 crossref_primary_10_1017_cjn_2021_102 crossref_primary_10_1371_journal_pone_0252236 crossref_primary_10_1038_s41572_024_00580_4 crossref_primary_10_1016_j_spen_2025_101209 crossref_primary_10_1136_jnnp_2020_324491 crossref_primary_10_1089_vim_2021_0187 crossref_primary_10_1128_JVI_01575_20 crossref_primary_10_22379_24224022421 crossref_primary_10_1093_brain_awab279 crossref_primary_10_1128_jvi_02322_24 crossref_primary_10_1016_S0140_6736_21_00517_1 crossref_primary_10_1038_s41598_022_22231_y crossref_primary_10_3389_fimmu_2024_1307546 crossref_primary_10_1136_jnnp_2020_324837 crossref_primary_10_1155_2023_5380946 crossref_primary_10_1186_s12974_021_02319_4 |
| Cites_doi | 10.3389/fmicb.2018.01018 10.1093/ofid/ofy261 10.1016/j.clineuro.2017.05.006 10.4269/ajtmh.17-0106 10.1128/JCM.43.1.335-339.2005 10.1093/brain/awt285 10.15585/mmwr.mm6544a4 10.1002/ana.410440512 10.1016/j.jns.2016.08.002 10.1186/s40478-017-0450-8 10.1136/jnnp-2016-314310 10.1056/NEJMoa1605564 10.1371/journal.pntd.0005869 10.1001/jamaneurol.2018.1058 10.1016/j.vaccine.2010.06.003 10.1371/journal.pntd.0006212 10.1016/S1474-4422(06)70603-2 10.1016/j.jcrc.2017.07.038 10.1016/j.jns.2017.02.029 10.1186/2049-3258-72-39 10.7326/M16-1842 10.4269/ajtmh.16-0323 10.1093/infdis/jix511 10.1056/NEJM199511233332102 10.1212/WNL.0000000000003038 10.1136/jnnp.62.6.641 10.1590/0037-8682-0327-2017 10.15585/mmwr.mm6534e1 10.3389/fneur.2016.00233 10.1016/j.ijid.2016.08.023 10.1001/jamaneurol.2017.1703 10.1093/cid/cix588 10.1097/IPC.0000000000000654 10.1007/s13365-018-0621-9 10.1007/s00415-011-6042-9 10.1111/jns.12284 10.3389/fmicb.2017.00042 10.1016/j.medcli.2016.02.002 10.1159/000324710 10.1093/brain/awy232 10.1038/nrneurol.2014.121 10.1212/WNL.51.4.1110 10.1016/j.jns.2017.09.001 10.4269/ajtmh.16-0397 10.1097/MD.0000000000003257 10.1186/2046-4053-4-1 10.1371/journal.pone.0143837 10.1212/WNL.0000000000002759 10.1016/j.tmaid.2017.03.012 10.3389/fimmu.2018.01640 10.1016/S0140-6736(16)30058-7 10.1002/ana.410350228 10.1212/WNL.0b013e3181f88345 10.1007/s00234-016-1687-9 10.1016/S0140-6736(16)00562-6 10.1093/cid/cir074 10.1016/S1473-3099(17)30333-X 10.1002/acn3.556 10.1136/jnnp-2014-307815 10.4269/ajtmh.16-0306 |
| ContentType | Journal Article |
| Copyright | 2020 Leonhard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2020 Leonhard et al 2020 Leonhard et al |
| Copyright_xml | – notice: 2020 Leonhard et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2020 Leonhard et al 2020 Leonhard et al |
| DBID | AAYXX CITATION NPM 3V. 7QL 7SS 7T2 7T7 7U9 7X7 7XB 88E 8C1 8FD 8FI 8FJ 8FK ABUWG AEUYN AFKRA AZQEC BENPR C1K CCPQU DWQXO F1W FR3 FYUFA GHDGH H94 H95 H97 K9. L.G M0S M1P M7N P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI 7X8 5PM DOA |
| DOI | 10.1371/journal.pntd.0008264 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Entomology Abstracts (Full archive) Health and Safety Science Abstracts (Full archive) Industrial and Applied Microbiology Abstracts (Microbiology A) Virology and AIDS Abstracts ProQuest_Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Public Health Database Technology Research Database Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central ASFA: Aquatic Sciences and Fisheries Abstracts Engineering Research Database Proquest Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality ProQuest Health & Medical Complete (Alumni) Aquatic Science & Fisheries Abstracts (ASFA) Professional ProQuest Health & Medical Collection PML(ProQuest Medical Library) Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts ProQuest Databases ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition MEDLINE - Academic PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef PubMed Publicly Available Content Database Aquatic Science & Fisheries Abstracts (ASFA) Professional Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality Environmental Sciences and Pollution Management ProQuest Central ProQuest One Sustainability ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Health & Medical Research Collection AIDS and Cancer Research Abstracts Health & Safety Science Abstracts Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ASFA: Aquatic Sciences and Fisheries Abstracts Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | PubMed Publicly Available Content Database MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: ProQuest Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | GBS and Zika virus: A systematic review and meta-analysis |
| EISSN | 1935-2735 |
| ExternalDocumentID | 2460993989 oai_doaj_org_article_ac66c7b9f9f0430d8149c211e5431ef4 PMC7205322 32339199 10_1371_journal_pntd_0008264 |
| Genre | Journal Article |
| GeographicLocations | Brazil Netherlands |
| GeographicLocations_xml | – name: Netherlands – name: Brazil |
| GrantInformation_xml | – fundername: ; grantid: 734584 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7X7 88E 8C1 8FI 8FJ AAFWJ AAUCC AAWOE AAYXX ABDBF ABUWG ACCTH ACGFO ACIHN ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS BAIFH BAWUL BBTPI BCNDV BENPR BPHCQ BVXVI BWKFM CCPQU CITATION CS3 DIK DU5 E3Z EAP EAS EBD ECGQY EMOBN ESX F5P FPL FYUFA GROUPED_DOAJ GX1 HMCUK HYE IAO IHR IHW ITC KQ8 M1P M48 O5R O5S OK1 OVT P2P PGMZT PHGZM PHGZT PIMPY PJZUB PPXIY PQQKQ PROAC PSQYO PV9 RNS RPM RZL SV3 TR2 TUS UKHRP 3V. ADRAZ ALIPV H13 IPNFZ M~E NPM RIG WOQ 7QL 7SS 7T2 7T7 7U9 7XB 8FD 8FK AZQEC C1K DWQXO F1W FR3 H94 H95 H97 K9. L.G M7N P64 PKEHL PQEST PQUKI 7X8 PUEGO 5PM AAPBV ABPTK BBAFP N95 |
| ID | FETCH-LOGICAL-c526t-ad1e335eb1c0a240cebf534edbda7d0464104d82da080bb33f0eaf95b4d8cf9f3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 38 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000558074700077&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1935-2735 1935-2727 |
| IngestDate | Mon Dec 05 23:10:23 EST 2022 Fri Oct 03 12:52:02 EDT 2025 Tue Nov 04 02:01:04 EST 2025 Thu Oct 02 06:38:15 EDT 2025 Sat Nov 29 14:38:53 EST 2025 Wed Feb 19 02:31:35 EST 2025 Sat Nov 29 02:19:29 EST 2025 Tue Nov 18 22:00:08 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c526t-ad1e335eb1c0a240cebf534edbda7d0464104d82da080bb33f0eaf95b4d8cf9f3 |
| Notes | new_version ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 SEL, CCBS, MLBF, JLB, SC and MFPMA declare no competing interests. BCJ has received funding from Annexon Biosciences, Baxter, CSL Behring, Hansa Biopharma and Grifols. |
| ORCID | 0000-0003-4832-6926 |
| OpenAccessLink | https://doaj.org/article/ac66c7b9f9f0430d8149c211e5431ef4 |
| PMID | 32339199 |
| PQID | 2460993989 |
| PQPubID | 1436337 |
| ParticipantIDs | plos_journals_2460993989 doaj_primary_oai_doaj_org_article_ac66c7b9f9f0430d8149c211e5431ef4 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7205322 proquest_miscellaneous_2395609254 proquest_journals_2460993989 pubmed_primary_32339199 crossref_citationtrail_10_1371_journal_pntd_0008264 crossref_primary_10_1371_journal_pntd_0008264 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-04-01 |
| PublicationDateYYYYMMDD | 2020-04-01 |
| PublicationDate_xml | – month: 04 year: 2020 text: 2020-04-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PLoS neglected tropical diseases |
| PublicationTitleAlternate | PLoS Negl Trop Dis |
| PublicationYear | 2020 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | JH Rees (pntd.0008264.ref062) 1995; 333 World Health Organization (pntd.0008264.ref003) 2016 JJ Sejvar (pntd.0008264.ref001) 2011; 36 RG Fabrizius (pntd.0008264.ref036) 2016; 95 J Beattie (pntd.0008264.ref034) 2018; 26 T Umapathi (pntd.0008264.ref015) 2018; 23 B Parra (pntd.0008264.ref032) 2016; 375 DH Hamer (pntd.0008264.ref040) 2017; 166 M Takahashi (pntd.0008264.ref063) 2005; 43 YA Rajabally (pntd.0008264.ref052) 2015; 86 L Ruts (pntd.0008264.ref070) 2010; 75 BC Jacobs (pntd.0008264.ref002) 1998; 51 C Caudie (pntd.0008264.ref053) 2011; 258 IRF da Silva (pntd.0008264.ref018) 2017; 74 CA Fontes (pntd.0008264.ref037) 2016; 58 MB Azevedo (pntd.0008264.ref019) 2018; 51 P Kassavetis (pntd.0008264.ref041) 2016; 87 E Dirlikov (pntd.0008264.ref033) 2016; 65 R Siu (pntd.0008264.ref046) 2016; 87 E Dirlikov (pntd.0008264.ref025) 2018; 75 N Acevedo (pntd.0008264.ref020) 2017; 8 VM Cao-Lormeau (pntd.0008264.ref004) 2016; 387 VN Nyaga (pntd.0008264.ref013) 2014; 72 M Nobrega (pntd.0008264.ref029) 2018; 27 O Simon (pntd.0008264.ref023) 2018; 24 R Mehta (pntd.0008264.ref021) 2018; 12 P Brasil (pntd.0008264.ref035) 2016; 387 L Watrin (pntd.0008264.ref048) 2016; 95 CH GeurtsvanKessel (pntd.0008264.ref039) 2018; 5 T Langerak (pntd.0008264.ref031) 2016; 7 K Rabelo (pntd.0008264.ref043) 2018; 9 JH Rees (pntd.0008264.ref054) 1994; 35 N van Leeuwen (pntd.0008264.ref068) 2016; 11 JPT GS Higgins (pntd.0008264.ref012) 2011 DR Gracey (pntd.0008264.ref067) 1982; 57 L Del Carpio Orantes (pntd.0008264.ref049) 2017 M Lozier (pntd.0008264.ref056) 2016; 65 JT Beaver (pntd.0008264.ref060) 2018; 9 A Uncini (pntd.0008264.ref061) 2017; 88 TSL Keesen (pntd.0008264.ref030) 2017; 17 SM Raboni (pntd.0008264.ref044) 2017; 19 ML Brito Ferreira (pntd.0008264.ref016) 2017; 97 FC Coelho (pntd.0008264.ref055) 2016; 51 TW Ho (pntd.0008264.ref051) 1995; 118 BR Wakerley (pntd.0008264.ref057) 2016; 369 BC Jacobs (pntd.0008264.ref008) 1997; 62 B Roze (pntd.0008264.ref026) 2017; 65 AY Doets (pntd.0008264.ref005) 2018; 141 AR Styczynski (pntd.0008264.ref027) 2017; 11 JJ Sejvar (pntd.0008264.ref010) 2011; 29 D Moher (pntd.0008264.ref009) 2015; 4 H Zambrano (pntd.0008264.ref047) 2016; 95 pntd.0008264.ref011 MS do Rosario (pntd.0008264.ref017) 2016; 95 B van den Berg (pntd.0008264.ref006) 2014; 10 JL Salinas (pntd.0008264.ref024) 2017; 381 G Gonzalez-Escobar (pntd.0008264.ref038) 2018; 41 E Reyna-Villasmil (pntd.0008264.ref045) 2016; 146 MC Durand (pntd.0008264.ref069) 2006; 5 T Fourié (pntd.0008264.ref065) 2018; 5 WE Villamil-Gomez (pntd.0008264.ref028) 2017; 16 FL Hiew (pntd.0008264.ref059) 2017; 158 RD Hadden (pntd.0008264.ref050) 1998; 44 E Miller (pntd.0008264.ref042) 2017; 375 C Fokke (pntd.0008264.ref058) 2014; 137 D Orlikowski (pntd.0008264.ref007) 2011; 52 SL Cumberworth (pntd.0008264.ref066) 2017; 5 L Del Carpio-Orantes (pntd.0008264.ref014) 2018 UU Sebastian (pntd.0008264.ref022) 2017; 42 LS Muñoz (pntd.0008264.ref064) 2017; 216 |
| References_xml | – start-page: 12 year: 2011 ident: pntd.0008264.ref012 article-title: Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 publication-title: The Cochrane Collaboration – year: 2018 ident: pntd.0008264.ref014 article-title: Guillain-Barre syndrome associated with Zika virus infection: Analysis of a cohort from the region of northern Veracruz in 2016–2017 publication-title: Neurologia – volume: 9 start-page: 1018 year: 2018 ident: pntd.0008264.ref043 article-title: Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-Barre Syndrome and Abortion publication-title: Front Microbiol doi: 10.3389/fmicb.2018.01018 – ident: pntd.0008264.ref011 – volume: 5 start-page: ofy261 issue: 11 year: 2018 ident: pntd.0008264.ref065 article-title: Variability of Zika Virus Incubation Period in Humans publication-title: Open Forum Infect Dis doi: 10.1093/ofid/ofy261 – volume: 158 start-page: 114 year: 2017 ident: pntd.0008264.ref059 article-title: Guillain-Barré Syndrome, variants & forms fruste: Reclassification with new criteria publication-title: Clin Neurol Neurosurg doi: 10.1016/j.clineuro.2017.05.006 – volume: 97 start-page: 1405 issue: 5 year: 2017 ident: pntd.0008264.ref016 article-title: Guillain-Barre Syndrome, Acute Disseminated Encephalomyelitis and Encephalitis Associated with Zika Virus Infection in Brazil: Detection of Viral RNA and Isolation of Virus during Late Infection publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.17-0106 – volume: 43 start-page: 335 issue: 1 year: 2005 ident: pntd.0008264.ref063 article-title: Epidemiology of Campylobacter jejuni isolated from patients with Guillain-Barré and Fisher syndromes in Japan publication-title: J Clin Microbiol doi: 10.1128/JCM.43.1.335-339.2005 – volume: 137 start-page: 33 issue: Pt 1 year: 2014 ident: pntd.0008264.ref058 article-title: Diagnosis of Guillain-Barré syndrome and validation of Brighton criteria publication-title: Brain doi: 10.1093/brain/awt285 – volume: 65 start-page: 1219 issue: 44 year: 2016 ident: pntd.0008264.ref056 article-title: Incidence of Zika Virus Disease by Age and Sex—Puerto Rico, November 1, 2015-October 20, 2016 publication-title: MMWR Morb Mortal Wkly Rep doi: 10.15585/mmwr.mm6544a4 – volume: 44 start-page: 780 issue: 5 year: 1998 ident: pntd.0008264.ref050 article-title: Electrophysiological classification of Guillain-Barre syndrome: clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barre Syndrome Trial Group publication-title: Ann Neurol doi: 10.1002/ana.410440512 – volume: 369 start-page: 43 year: 2016 ident: pntd.0008264.ref057 article-title: Clinical classification of 103 Japanese patients with Guillain-Barre syndrome publication-title: J Neurol Sci doi: 10.1016/j.jns.2016.08.002 – volume: 5 start-page: 50 issue: 1 year: 2017 ident: pntd.0008264.ref066 article-title: Zika virus tropism and interactions in myelinating neural cell cultures: CNS cells and myelin are preferentially affected publication-title: Acta Neuropathol Commun doi: 10.1186/s40478-017-0450-8 – volume: 88 start-page: 266 issue: 3 year: 2017 ident: pntd.0008264.ref061 article-title: Zika virus infection and Guillain-Barré syndrome: a review focused on clinical and electrophysiological subtypes publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2016-314310 – volume: 375 start-page: 1513 issue: 16 year: 2016 ident: pntd.0008264.ref032 article-title: Guillain-Barré syndrome associated with Zika virus infection in Colombia publication-title: N Engl J Med doi: 10.1056/NEJMoa1605564 – volume: 11 start-page: e0005869 issue: 8 year: 2017 ident: pntd.0008264.ref027 article-title: Increased rates of Guillain-Barré syndrome associated with Zika virus outbreak in the Salvador metropolitan area, Brazil publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0005869 – volume: 75 start-page: 1089 issue: 9 year: 2018 ident: pntd.0008264.ref025 article-title: Clinical Features of Guillain-Barre Syndrome With vs Without Zika Virus Infection, Puerto Rico, 2016 publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2018.1058 – volume-title: Zika situation report 5 February 2016 year: 2016 ident: pntd.0008264.ref003 – volume: 29 start-page: 599 issue: 3 year: 2011 ident: pntd.0008264.ref010 article-title: Guillain-Barré syndrome and Fisher syndrome: case definitions and guidelines for collection, analysis, and presentation of immunization safety data publication-title: Vaccine doi: 10.1016/j.vaccine.2010.06.003 – volume: 12 start-page: e0006212 issue: 2 year: 2018 ident: pntd.0008264.ref021 article-title: The spectrum of neurological disease associated with Zika and chikungunya viruses in adults in Rio de Janeiro, Brazil: A case series publication-title: PLoS Negl Trop Dis doi: 10.1371/journal.pntd.0006212 – volume: 5 start-page: 1021 issue: 12 year: 2006 ident: pntd.0008264.ref069 article-title: Clinical and electrophysiological predictors of respiratory failure in Guillain-Barre syndrome: a prospective study publication-title: Lancet Neurol doi: 10.1016/S1474-4422(06)70603-2 – volume: 42 start-page: 275 year: 2017 ident: pntd.0008264.ref022 article-title: Zika virus-induced neurological critical illness in Latin America: Severe Guillain-Barre Syndrome and encephalitis publication-title: J Crit Care doi: 10.1016/j.jcrc.2017.07.038 – volume: 375 start-page: 367 year: 2017 ident: pntd.0008264.ref042 article-title: Probable Zika virus-associated Guillain-Barre syndrome: Challenges with clinico-laboratory diagnosis publication-title: J Neurol Sci doi: 10.1016/j.jns.2017.02.029 – volume: 72 start-page: 39 issue: 1 year: 2014 ident: pntd.0008264.ref013 article-title: Metaprop: a Stata command to perform meta-analysis of binomial dat publication-title: Arch Public Health doi: 10.1186/2049-3258-72-39 – volume: 118 start-page: 597 issue: Pt 3 year: 1995 ident: pntd.0008264.ref051 article-title: Guillain-Barre syndrome in northern China. Relationship to Campylobacter jejuni infection and anti-glycolipid antibodies publication-title: Brain – volume: 166 start-page: 99 issue: 2 year: 2017 ident: pntd.0008264.ref040 article-title: Travel-Associated Zika Virus Disease Acquired in the Americas Through February 2016: A GeoSentinel Analysis publication-title: Ann Intern Med doi: 10.7326/M16-1842 – volume: 95 start-page: 894 issue: 4 year: 2016 ident: pntd.0008264.ref047 article-title: Zika Virus and Chikungunya Virus CoInfections: A Series of Three Cases from a Single Center in Ecuador publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.16-0323 – volume: 216 start-page: S897 issue: suppl_10 year: 2017 ident: pntd.0008264.ref064 article-title: Neuroviruses Emerging in the Americas S. Neurological Implications of Zika Virus Infection in Adults publication-title: J Infect Dis doi: 10.1093/infdis/jix511 – volume: 333 start-page: 1374 issue: 21 year: 1995 ident: pntd.0008264.ref062 article-title: Campylobacter jejuni infection and Guillain-Barré syndrome publication-title: N Engl J Med doi: 10.1056/NEJM199511233332102 – volume: 41 start-page: e136 year: 2018 ident: pntd.0008264.ref038 article-title: Prolonged Zika virus viremia in a patient with Guillain-Barre syndrome in Trinidad and Tobago publication-title: Rev Panam Salud Publica – volume: 87 start-page: 1623 issue: 15 year: 2016 ident: pntd.0008264.ref046 article-title: Acute Zika infection with concurrent onset of Guillain-Barré Syndrome publication-title: Neurology doi: 10.1212/WNL.0000000000003038 – volume: 62 start-page: 641 issue: 6 year: 1997 ident: pntd.0008264.ref008 article-title: Cytomegalovirus infections and anti-GM2 antibodies in Guillain-Barre syndrome publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp.62.6.641 – volume: 51 start-page: 347 issue: 3 year: 2018 ident: pntd.0008264.ref019 article-title: Neurologic manifestations in emerging arboviral diseases in Rio de Janeiro City, Brazil, 2015–2016 publication-title: Rev Soc Bras Med Trop doi: 10.1590/0037-8682-0327-2017 – volume: 65 start-page: 910 issue: 34 year: 2016 ident: pntd.0008264.ref033 article-title: Guillain-Barre Syndrome During Ongoing Zika Virus Transmission—Puerto Rico, January 1-July 31, 2016 publication-title: MMWR Morb Mortal Wkly Rep doi: 10.15585/mmwr.mm6534e1 – volume: 7 start-page: 233 year: 2016 ident: pntd.0008264.ref031 article-title: Zika Virus Infection and Guillain-Barre Syndrome in Three Patients from Suriname publication-title: Front Neurol doi: 10.3389/fneur.2016.00233 – volume: 51 start-page: 128 year: 2016 ident: pntd.0008264.ref055 article-title: Higher incidence of Zika in adult women than adult men in Rio de Janeiro suggests a significant contribution of sexual transmission from men to women publication-title: Int J Infect Dis doi: 10.1016/j.ijid.2016.08.023 – volume: 74 start-page: 1190 issue: 10 year: 2017 ident: pntd.0008264.ref018 article-title: Neurologic Complications Associated With the Zika Virus in Brazilian Adults publication-title: JAMA Neurol doi: 10.1001/jamaneurol.2017.1703 – volume: 65 start-page: 1462 issue: 9 year: 2017 ident: pntd.0008264.ref026 article-title: Guillain-Barré Syndrome Associated With Zika Virus Infection in Martinique in 2016: A Prospective Study publication-title: Clin Infect Dis doi: 10.1093/cid/cix588 – volume: 26 start-page: e80 issue: 6 year: 2018 ident: pntd.0008264.ref034 article-title: Zika Virus-Associated Guillain-Barre Syndrome in a Returning US Traveler publication-title: Infect Dis Clin Pract (Baltim Md) doi: 10.1097/IPC.0000000000000654 – volume: 24 start-page: 362 issue: 3 year: 2018 ident: pntd.0008264.ref023 article-title: Zika virus outbreak in New Caledonia and Guillain-Barré syndrome: a case-control study publication-title: J Neurovirol doi: 10.1007/s13365-018-0621-9 – volume: 19 issue: 4 year: 2017 ident: pntd.0008264.ref044 article-title: Flavivirus cross-reactivity in serological tests and Guillain-Barré syndrome in a hematopoietic stem cell transplant patient: A case report publication-title: Transpl Infect Dis – volume: 258 start-page: 1958 issue: 11 year: 2011 ident: pntd.0008264.ref053 article-title: Preceding infections and anti-ganglioside antibody profiles assessed by a dot immunoassay in 306 French Guillain-Barre syndrome patients publication-title: J Neurol doi: 10.1007/s00415-011-6042-9 – volume: 23 start-page: 197 issue: 3 year: 2018 ident: pntd.0008264.ref015 article-title: The 2016 Singapore Zika virus outbreak did not cause a surge in Guillain-Barre syndrome publication-title: J Peripher Nerv Syst doi: 10.1111/jns.12284 – volume: 8 start-page: 42 year: 2017 ident: pntd.0008264.ref020 article-title: Zika Virus, Chikungunya Virus, and Dengue Virus in Cerebrospinal Fluid from Adults with Neurological Manifestations, Guayaquil, Ecuador publication-title: Front Microbiol doi: 10.3389/fmicb.2017.00042 – volume: 146 start-page: 331 issue: 7 year: 2016 ident: pntd.0008264.ref045 article-title: Guillain-Barré syndrome due to Zika virus during pregnancy publication-title: Med Clin (Barc) doi: 10.1016/j.medcli.2016.02.002 – volume: 36 start-page: 123 issue: 2 year: 2011 ident: pntd.0008264.ref001 article-title: Population incidence of Guillain-Barré syndrome: a systematic review and meta-analysis publication-title: Neuroepidemiology doi: 10.1159/000324710 – volume: 141 start-page: 2866 issue: 10 year: 2018 ident: pntd.0008264.ref005 article-title: Regional variation of Guillain-Barré syndrome publication-title: Brain doi: 10.1093/brain/awy232 – volume: 10 start-page: 469 issue: 8 year: 2014 ident: pntd.0008264.ref006 article-title: Guillain-Barré syndrome: pathogenesis, diagnosis, treatment and prognosis publication-title: Nat Rev Neurol doi: 10.1038/nrneurol.2014.121 – volume: 51 start-page: 1110 issue: 4 year: 1998 ident: pntd.0008264.ref002 article-title: The spectrum of antecedent infections in Guillain-Barré syndrome: a case-control study publication-title: Neurology doi: 10.1212/WNL.51.4.1110 – year: 2017 ident: pntd.0008264.ref049 article-title: Incidence of Guillain-Barre syndrome at a secondary centre during the 2016 zika outbreak publication-title: Neurologia – volume: 381 start-page: 272 year: 2017 ident: pntd.0008264.ref024 article-title: Zika virus disease-associated Guillain-Barré syndrome-Barranquilla, Colombia 2015–2016 publication-title: J Neurol Sci doi: 10.1016/j.jns.2017.09.001 – volume: 95 start-page: 1161 issue: 5 year: 2016 ident: pntd.0008264.ref036 article-title: Guillain-Barre Syndrome Associated with Zika Virus Infection in a Traveler Returning from Guyana publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.16-0397 – volume: 95 start-page: e3257 issue: 14 year: 2016 ident: pntd.0008264.ref048 article-title: Guillain-Barre Syndrome (42 Cases) Occurring During a Zika Virus Outbreak in French Polynesia publication-title: Medicine (Baltimore) doi: 10.1097/MD.0000000000003257 – volume: 57 start-page: 742 issue: 12 year: 1982 ident: pntd.0008264.ref067 article-title: Respiratory failure in Guillain-Barre syndrome: a 6-year experience publication-title: Mayo Clin Proc – volume: 4 start-page: 1 year: 2015 ident: pntd.0008264.ref009 article-title: Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement publication-title: Syst Rev doi: 10.1186/2046-4053-4-1 – volume: 11 start-page: e0143837 issue: 2 year: 2016 ident: pntd.0008264.ref068 article-title: Hospital Admissions, Transfers and Costs of Guillain-Barré Syndrome publication-title: PLOS ONE doi: 10.1371/journal.pone.0143837 – volume: 27 start-page: e2017039 issue: 2 year: 2018 ident: pntd.0008264.ref029 article-title: Outbreak of Guillain-Barre syndrome possibly related to prior Zika virus infection, Metropolitan Region of Recife, Pernambuco, Brazil, 2015 publication-title: Epidemiol Serv Saude – volume: 87 start-page: 336 issue: 3 year: 2016 ident: pntd.0008264.ref041 article-title: Zika virus-associated Guillain-Barre syndrome variant in Haiti publication-title: Neurology doi: 10.1212/WNL.0000000000002759 – volume: 16 start-page: 62 year: 2017 ident: pntd.0008264.ref028 article-title: Guillain-Barré syndrome during the Zika virus outbreak in Sucre, Colombia, 2016 publication-title: Travel Med Infect Dis doi: 10.1016/j.tmaid.2017.03.012 – volume: 9 start-page: 1640 year: 2018 ident: pntd.0008264.ref060 article-title: Evolution of Two Major Zika Virus Lineages: Implications for Pathology, Immune Response, and Vaccine Development publication-title: Front Immunol doi: 10.3389/fimmu.2018.01640 – volume: 387 start-page: 1482 issue: 10026 year: 2016 ident: pntd.0008264.ref035 article-title: Guillain-Barre syndrome associated with Zika virus infection publication-title: Lancet doi: 10.1016/S0140-6736(16)30058-7 – volume: 35 start-page: 248 issue: 2 year: 1994 ident: pntd.0008264.ref054 article-title: Campylobacter jejuni and Guillain-Barré syndrome publication-title: Ann Neurol doi: 10.1002/ana.410350228 – volume: 75 start-page: 1439 issue: 16 year: 2010 ident: pntd.0008264.ref070 article-title: Pain in Guillain-Barré syndrome: a long-term follow-up study publication-title: Neurology doi: 10.1212/WNL.0b013e3181f88345 – volume: 58 start-page: 837 issue: 8 year: 2016 ident: pntd.0008264.ref037 article-title: Magnetic resonance imaging findings in Guillain-Barre syndrome caused by Zika virus infection publication-title: Neuroradiology doi: 10.1007/s00234-016-1687-9 – volume: 387 start-page: 1531 issue: 10027 year: 2016 ident: pntd.0008264.ref004 article-title: Guillain-Barre Syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study publication-title: Lancet doi: 10.1016/S0140-6736(16)00562-6 – volume: 52 start-page: 837 issue: 7 year: 2011 ident: pntd.0008264.ref007 article-title: Guillain-Barre syndrome following primary cytomegalovirus infection: a prospective cohort study publication-title: Clin Infect Dis doi: 10.1093/cid/cir074 – volume: 17 start-page: 693 issue: 7 year: 2017 ident: pntd.0008264.ref030 article-title: Guillain-Barre syndrome and arboviral infection in Brazil publication-title: Lancet Infect Dis doi: 10.1016/S1473-3099(17)30333-X – volume: 5 start-page: 606 issue: 5 year: 2018 ident: pntd.0008264.ref039 article-title: Zika virus and Guillain-Barre syndrome in Bangladesh publication-title: Ann Clin Transl Neurol doi: 10.1002/acn3.556 – volume: 86 start-page: 115 issue: 1 year: 2015 ident: pntd.0008264.ref052 article-title: Electrophysiological diagnosis of Guillain-Barré syndrome subtype: could a single study suffice? publication-title: J Neurol Neurosurg Psychiatry doi: 10.1136/jnnp-2014-307815 – volume: 95 start-page: 1157 issue: 5 year: 2016 ident: pntd.0008264.ref017 article-title: Guillain-Barre Syndrome After Zika Virus Infection in Brazil publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.16-0306 |
| SSID | ssj0059581 |
| Score | 2.4600205 |
| Snippet | The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific... Background The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a... Guillain-Barré syndrome (GBS) is a rare but severe neurological disease, characterized by an acute onset flaccid paralysis. GBS is thought to be caused by an... BackgroundThe Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a... Background The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a... |
| SourceID | plos doaj pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0008264 |
| SubjectTerms | Bias Biology and life sciences Campylobacter Case reports Cohorts Cytomegalovirus Demographics Demyelination DNA Electrical impedance Electrophysiology Epidemiology Guillain-Barre syndrome Heterogeneity Infections Infectious diseases Laboratories Literature reviews Medicine and Health Sciences Meta-analysis Neurology Nucleotide sequence Paralysis Pathogens PCR Phenotypes Protocols Reflexes Research and Analysis Methods Sensorimotor system Signs and symptoms Symptoms Systematic review Tropical diseases Variables Vector-borne diseases Viruses Zika virus |
| SummonAdditionalLinks | – databaseName: ProQuest_Health & Medical Collection dbid: 7X7 link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELagINQLb9qFgozENe2uncQxF9QiCgeoOIC04hL5WSJKsiTZ_hD-Bb-DP8aM46QsquDAKVLsPJyZeN7fEPIMRIRjuZ4nwDBgoJgiTYoM3RxcScGsS70NlH4rTk6K5VK-jw63LqZVjnti2KhtY9BHfsDSHJQZLgv5YvUtwa5RGF2NLTSukmvYNhv5XCwngyuTWWhSCjoK1l0xEUvnuFgcRErtr-re7gdBmKcboikg-CPi6VnTXaZ9_plE-ZtUOr71v-u5TW5GfZQeDgx0h1xx9V1y412MuN8j31-vsS9RVSdHqm1__qAjxAENVTDO0r6hn6ovip5X7bqjY3JX_Zwe0guYaDqUyFBVW_rV9SpREQyFNp6CDkrHCs0wI_bmCV6XcXOmmIzWoMf4Pvl4_OrDyzdJ7OOQmIzlfaLswnGegVQwcwUahHHaZzx1VlslLMZWwSa0BbMK1FetOfdzp7zMNJw0Xnr-gGzVTe12CbUmlcJbA4cUi3DVXAvjc75wWmo5T2eEjyQsTQQ5x14bZ2WI3AkwdobvWiLhy0j4GUmmq1YDyMc_5h8hd0xzEaI7nGja0zL-8aUyeW6ElrAAxFWzBdiiBsxth-gDzsNNdpG3xgd05QVHzMjeyDOXDz-dhmEzwAiPql2zhjkczV0JRv-M7AzsOb0kZ5zLhYSrxQbjbqxic6SuPgfAccGwfwh7-PfXekS2GTojQlrTHtnq27V7TK6b877q2ifhz_wF2X1H-g priority: 102 providerName: ProQuest – databaseName: PLoS_OA刊 dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3NbtQwELagIMSFf-iWgozENSWxkzjura26cChVDyBVXCL_qhElqbLZPghvwXPwYsw4zpatWiFOkWI78c_Yns_j-YaQ97BFOFbqNAGBAYBiqjypCjzm4EoKZl3ubRjpI3F8XJ2eypMroHjNgs9F9iH26c5FO9idsGWV-V1yj_GyRLA1PzmaVt5CFlUW3eNuK7m2_QSWfmQ1Pe8WN2mY1y9K_rXzzB__b52fkEdRx6R7o1A8JXdc-4w8-Byt6M_Jz49LjDXUtMm-6vvfv-hEW0CDZ4uzdOjot-a7opdNv1zQ6cJWu0v36BX1Mx3dXqhqLf3hBpWoSHBCO09Br6ST12XIEePthJOUacGleMGsw1PgF-Tr_PDLwackxmZITMHKIVE2c5wXsNKbVIFWYJz2Bc-d1VYJi_ZSwHm2YlaBSqo15z51ystCw0vjpecvyUbbtW6TUGtyKbw18MjRsValWhhf8sxpqWWazwifhqw2kbgc42ec18EaJwDAjP1aY3fXsbtnJFmVuhiJO_6Rfx-lYZUXabfDCxjXOs7iWpmyNEJLaABypdkK8KUBCO2QUcB5-MgmytL0g0XN8hJUcC4rOSPbk3zdnPxulQwTHK02qnXdEvJwhLASgPyMvBrFcVVJzjiXmYTSYk1Q11qxntI2Z4FEXDCMCcK2bq_xa_KQ4eFCuKa0TTaGfunekPvmcmgW_dsw8_4AYTU0Ww priority: 102 providerName: Public Library of Science |
| Title | Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32339199 https://www.proquest.com/docview/2460993989 https://www.proquest.com/docview/2395609254 https://pubmed.ncbi.nlm.nih.gov/PMC7205322 https://doaj.org/article/ac66c7b9f9f0430d8149c211e5431ef4 http://dx.doi.org/10.1371/journal.pntd.0008264 |
| Volume | 14 |
| WOSCitedRecordID | wos000558074700077&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1935-2735 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0059581 issn: 1935-2735 databaseCode: DOA dateStart: 20070101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1935-2735 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0059581 issn: 1935-2735 databaseCode: BENPR dateStart: 20071001 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Health & Medical Collection customDbUrl: eissn: 1935-2735 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0059581 issn: 1935-2735 databaseCode: 7X7 dateStart: 20071001 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Publicly Available Content Database customDbUrl: eissn: 1935-2735 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0059581 issn: 1935-2735 databaseCode: PIMPY dateStart: 20071001 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1935-2735 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0059581 issn: 1935-2735 databaseCode: 8C1 dateStart: 20071001 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVATS databaseName: PLoS_OA刊 customDbUrl: eissn: 1935-2735 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0059581 issn: 1935-2735 databaseCode: FPL dateStart: 20070101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwELagIMQF8d9AWRmJa9qsncQxt27VBaR2FSGQFi6Rf0VESapsti_CC3DlNeDFGDvO0kWVeuHiSLajxJ6xZ8ae-QahVyAiDMllEgPDgIGiijQuMnfMQQVnRJvUak_pE7ZYFMslLy-l-nI-YQM88DBxB0LluWKSW24dPJUuQKVXYLUYF8RtrEcCTRgfjalhD8545tOTgnbiIq4IC0FzlE0PAo32z5te73sRmKdbQslj9zus07N2dZXe-a_75CV5NL-P7gVFEh8OA3iAbpjmIbpzGq7KH6Hvb9YuoVDdxDPRdb9_4hGbAPvwFaNx3-LP9VeBL-puvcKjV1bzGh_--vEX4BkPwS1YNBp_M72IRYAxwa3FoD3iMbbS9whZdfx5ybitYudG1rqz3sfo4_z4w9HbOGRgiFVG8j4WemoozWA_V4kA2a-MtBlNjZZaMO1uRcGa0wXRAhRPKSm1iRGWZxIqFVCMPkE7TduYXYS1SjmzWsEjdeGzIpFM2RxoKLnkSRohOpKgUgGe3GXJOKv8nRsDM2WY2MoRrgqEi1C8eet8gOe4pv_MUXfT14Fr-wpguSqwXHUdy0Vo1_HG-IFVRdIcFG3KCx6hvZFfrm5-uWmGZezuZkRj2jX0oc5Q5WCuR-jpwF6bn6SEUj7l8DbbYrytUWy3NPUXDxXOiMv8QZ79j2E_R3eJO2zwbkt7aKfv1uYFuq0u-nrVTdBNtmS-LKAsjqYTdGt2vCjfT_zKhHJenkBd-e60_PQHM-9Bsg |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dbtMwFLZGh4Ab_mGFAUaCy2yNncQxEkIbMFatrXoxpMFNcGxnqxhJSdMhXoO34IaX4MU4x0k6iia42gVXlWLHTZzP58c-5zuEPAEVYVmU9jwADDgoOg68OMRtDq6kYMYGmXFfeiBGo_jgQI5XyI82FwbDKluZ6AS1KTTukW-yIAJjhstYvph-9rBqFJ6utiU0aljs2a9fwGWbPe-_gu_7lLGd1_svd72mqoCnQxZVnjK-5TwEGaV7CvSZtmkW8sCa1Chh8KQPPBQTM6PAmEpTzrOeVZkMU7ioM5lxGPcCWQ0Q7B2yOu4Px-9a2R_K0JVFBasIM72YaJL1uPA3G2xsTPPKbDjVGwVLytDVDECO1eNidpa9-2fY5m96cOfa_zaD18nVxuKmW_USuUFWbH6TXBo2MQW3yLc3c6y8NMm9bVWWP7_TlsSBujwfa2hV0PeTj4qeTMr5jLbha_kzukVPibBpnQREVW7oJ1spTzV0L7TIKFjZtM1BdT2a6kNuX6lVPxTD7QrcE79N3p7LjNwhnbzI7RqhRgdSZEbDT4BpxqqXCp1F3LepTGUv6BLeQibRDY07VhM5TtzZpAB3rp7XBIGWNEDrEm9x17SmMflH_21E46IvkpC7C0V5mDQyLVE6irRIJbwAMseZGLxtzXzfIr-CzWCQNcRy-wez5BSBXbLeYvTs5seLZhB3eIalclvMoQ9Hh16yEEa_Wy-HxUNyxrn0JdwtlhbK0lsst-STI0epLhhWSGH3_v5Yj8jl3f3hIBn0R3v3yRWGWy8uiGuddKpybh-Qi_qkmszKh41coOTDeS-kX7wUqbI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dbtMwFLZGhyZu-IcVBhgJLrM2dv6MhNDGKFTbql6ANHYTHNvZKkZS0nSI1-AteAVueTHOcZyOogmudsFVpdhxE-f8-5zvEPIEVIRhUdb3gGDAQVFJ4CUhhjm4FDHTJsi1_dJ78WiUHByI8Qr50dbCYFplKxOtoNalwhh5jwURGDNcJKKXu7SI8c7gxfSzhx2k8KS1bafRkMiu-foF3LfZ8-EOfOunjA1evX35xnMdBjwVsqj2pPYN5yHIK9WXoNuUyfKQB0ZnWsYaT_3AW9EJ0xIMqyzjPO8bmYswg4sqFzmHdS-RVTDJA9Yhq-Ph_vh9qwdCEdoWqWAhYdUXi13hHo_9nqOTzWlR602rhqNgSTHa_gGIt3pSzs6zff9M4fxNJw6u_c-7eZ1cdZY43WpY5wZZMcVNsrbvcg1ukW-v59iRaVJ427Kqfn6nLbgDtfU_RtO6pIeTj5KeTqr5jLZpbcUzukXPALJpUxxEZaHpJ1NLTzoYGFrmFKxv2tam2hmuK5GNN7VqiWIaXomx8tvk3YXsyB3SKcrCrBOqVSDiXCv4CbD8WPazWOUR900mMtEPuoS35JMqB--OXUZOUntmGYOb1-xrikSXOqLrEm9x17SBN_nH_G2kzMVcBCe3F8rqKHWyLpUqilScCXgBRJTTCXjhivm-QdwFk8Mi60jX7R_M0jNq7JKNll7PH368GAYxiGdbsjDlHOZwdPQFC2H1uw1rLB6SM86FL-DueIlplt5ieaSYHFuo9Zhh5xR27--P9YisAfeke8PR7n1yhWFExuZ2bZBOXc3NA3JZndaTWfXQiQhKPlw0H_0CkUiycg |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Guillain-Barr%C3%A9+syndrome+related+to+Zika+virus+infection%3A+A%C2%A0systematic+review+and+meta-analysis+of+the+clinical+and+electrophysiological+phenotype&rft.jtitle=PLoS+neglected+tropical+diseases&rft.au=Leonhard%2C+Sonja+E&rft.au=Bresani-Salvi%2C+Cristiane+C&rft.au=Lyra+Batista%2C+Joanna+D&rft.au=Cunha%2C+Sergio&rft.date=2020-04-01&rft.eissn=1935-2735&rft.volume=14&rft.issue=4&rft.spage=e0008264&rft_id=info:doi/10.1371%2Fjournal.pntd.0008264&rft_id=info%3Apmid%2F32339199&rft.externalDocID=32339199 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1935-2735&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1935-2735&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1935-2735&client=summon |