Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis

Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which one or more lipoprotein lipid-related entities account for this relationship remains unclear. Using genetic instruments for lipoprotein lipid traits implemented through multivariable Mendelian random...

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Bibliographic Details
Published in:	PLoS medicine Vol. 17; no. 3; p. e1003062
Main Authors:	Richardson, Tom G., Sanderson, Eleanor, Palmer, Tom M., Ala-Korpela, Mika, Ference, Brian A., Davey Smith, George, Holmes, Michael V.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.03.2020 Public Library of Science (PLoS)
Subjects:	Adult Aged Apolipoprotein A Apolipoprotein A-I Apolipoprotein A-I - blood Apolipoprotein A-I - genetics Apolipoprotein B Apolipoprotein B-100 - blood Apolipoprotein B-100 - genetics Apolipoproteins Biology and Life Sciences Biomarkers - blood Cardiovascular disease Cholesterol Cholesterol, HDL - blood Cholesterol, HDL - genetics Cholesterol, LDL - blood Cholesterol, LDL - genetics Coronary artery disease Coronary Disease - blood Coronary Disease - diagnosis Coronary Disease - genetics Epidemiology Female Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Heart diseases High density lipoprotein Humans Lipid metabolism Lipids Low density lipoprotein Male Medicine and Health Sciences Mendelian Randomization Analysis Middle Aged Multivariate Analysis Phenotype Polymorphism, Single Nucleotide Preventive medicine Risk Assessment Risk Factors Single-nucleotide polymorphism Standard deviation Triglycerides Triglycerides - blood Melbourne Victoria Australia United Kingdom > UK Australia Finland
ISSN:	1549-1676, 1549-1277, 1549-1676
Online Access:	Get full text
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