Comparing various scoring system for predicting overall survival according to treatment modalities in hepatocellular carcinoma focused on Platelet-albumin-bilirubin (PALBI) and albumin-bilirubin (ALBI) grade: A nationwide cohort study

We evaluated the ability of various grading scales including platelet-albumin-bilirubin (PALBI) and albumin-bilirubin (ALBI) grades to predict overall survival (OS) according to treatment modality in patients with hepatocellular carcinoma (HCC). The cohort of 6,669 patients with HCC was selected ran...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PloS one Ročník 14; číslo 5; s. e0216173
Hlavní autoři: Lee, Soon Kyu, Song, Myeong Jun, Kim, Seok Hwan, Park, Misun
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 02.05.2019
Public Library of Science (PLoS)
Témata:
Ablation
Aged
Albumin
Bilirubin
Bilirubin - analysis
Biology and Life Sciences
Biomarkers, Tumor
Blood Platelets - pathology
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Cohort analysis
Cohort Studies
Evaluation
Female
Gastroenterology
Hepatitis
Hepatitis B
Hepatocellular carcinoma
Hepatology
Humans
Hypertension
Internal medicine
Kaplan-Meier Estimate
Laboratories
Liver
Liver - pathology
Liver cancer
Liver diseases
Liver Function Tests
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Male
Medical imaging
Medical prognosis
Medicine
Medicine and Health Sciences
Middle Aged
Multivariate analysis
NMR
Nuclear magnetic resonance
Oncology
Physical Sciences
Platelets
Prognosis
Quality
Radio frequency
Republic of Korea - epidemiology
Retrospective Studies
Risk analysis
Risk factors
ROC Curve
Serum Albumin, Human - analysis
Surgery
Survival
Survival Analysis
Transplants & implants
Viruses
Republic of Korea
South Korea
Japan
ISSN:1932-6203, 1932-6203
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:We evaluated the ability of various grading scales including platelet-albumin-bilirubin (PALBI) and albumin-bilirubin (ALBI) grades to predict overall survival (OS) according to treatment modality in patients with hepatocellular carcinoma (HCC). The cohort of 6,669 patients with HCC was selected randomly from the 2008-2012 national cohort of the Korean Central Cancer Registry. The OS of 6,507 of these patients was evaluated using the Child-Turcotte-Pugh (CTP) class, Model for End-stage Liver Disease (MELD) score, and ALBI and PALBI grades. The patient's mean age was 59.7 years. The most patients were hepatitis B virus (63.4%) and CTP class A (71.8%). The median OS durations of PALBI grade1 (38.4%), grade2 (33.2%), and grade3 (28.4%) patients were 81, 30, and 5 months, respectively (P<0.001). The PALBI grade had a larger area under the receiver operator characteristic curve (AUC) than did the CTP class, MELD score, and ALBI grade (overall AUC: 0.675 vs. 0.633, 0.645, and 0.642, respectively; P < 0.001). Moreover, the PALBI and ALBI grades enabled sub-classification of CTP A patients (P < 0.001). In a multivariate analysis, the PALBI and ALBI grades were significant risk factors for OS (P < 0.05). According to treatment modality, the PALBI grade was predictive of OS in patients receiving transarterial chemoembolization or supportive care. The ALBI grade was predictive of OS in patients undergoing surgical resection or radiofrequency ablation. The PALBI and ALBI grades are more reliable for accessing liver function and predicting OS in patients with HCC. Moreover, according to treatment modality, appropriate use of the ALBI and PALBI grades will enable accurate determination of the prognosis of patients with HCC.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0216173