DNA Microarray Profiling Highlights Nrf2-Mediated Chemoprevention Targeted by Wasabi-Derived Isothiocyanates in HepG2 Cells

6-MSITC and 6-MTITC are sulforaphane (SFN) analogs found in Japanese Wasabi. As we reported previously, Wasabi isothiocyanates (ITCs) are activators of Nrf2-antioxidant response element pathway, and also inhibitors of pro-inflammatory cyclooxygenase-2. This study is the first to assess the global ch...

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Bibliographic Details
Published in:	Nutrition and cancer Vol. 69; no. 1; pp. 105 - 116
Main Authors:	Trio, Phoebe Zapanta, Kawahara, Atsuyoshi, Tanigawa, Shunsuke, Sakao, Kozue, Hou, De-Xing
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 02.01.2017 Taylor & Francis Ltd
Subjects:	Anticarcinogenic Agents - pharmacology antioxidant activity Antioxidants Cancer therapies chemoprevention Deoxyribonucleic acid DNA DNA microarrays Eutrema japonica Gene expression gene expression regulation genes glutamic acid Hep G2 Cells human cell lines Humans isothiocyanates Isothiocyanates - pharmacology metabolism neoplasms NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Oligonucleotide Array Sequence Analysis - methods oligonucleotides prostaglandin synthase reverse transcriptase polymerase chain reaction Transcriptome - drug effects Wasabia - chemistry Western blotting
ISSN:	0163-5581, 1532-7914, 1532-7914
Online Access:	Get full text
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