First report of naturally infected Aedes aegypti with chikungunya virus genotype ECSA in the Americas

The worldwide expansion of new emergent arboviruses such as Chikungunya and Zika reinforces the importance in understanding the role of mosquito species in spreading these pathogens in affected regions. This knowledge is essential for developing effective programs based on species specificity to avo...

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Veröffentlicht in:PLoS neglected tropical diseases Jg. 11; H. 6; S. e0005630
Hauptverfasser: Costa-da-Silva, André Luis, Ioshino, Rafaella Sayuri, Petersen, Vivian, Lima, Antonio Fernando, Cunha, Marielton dos Passos, Wiley, Michael R., Ladner, Jason T., Prieto, Karla, Palacios, Gustavo, Costa, Danuza Duarte, Suesdek, Lincoln, Zanotto, Paolo Marinho de Andrade, Capurro, Margareth Lara
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 01.06.2017
Public Library of Science (PLoS)
Schlagworte:
Aedes - virology
Aedes aegypti
Animals
Aquatic insects
Biology and life sciences
Brazil
Chikungunya Fever - transmission
Chikungunya virus
Chikungunya virus - isolation & purification
Computer and Information Sciences
Culex - virology
Dengue
Dengue fever
Dengue Virus
Disease transmission
DNA
Encephalitis
Endemic species
Female
Genomes
Genotype
Genotype & phenotype
Genotypes
Higher education
Human diseases
Identification
Infectious diseases
Insect Vectors - virology
Male
Medical research
Medicine and Health Sciences
Mosquitoes
Mutation
Nucleotide sequence
Outbreaks
PCR
People and places
Phylogeny
Polymerase chain reaction
Research and Analysis Methods
Sequence Analysis, RNA
Sequencing
Species
Species Specificity
Specificity
Transmission
Tropical diseases
Vector-borne diseases
Vectors
Viral diseases
Virology
Viruses
West Nile virus
Zika Virus
Brazil
Rio de Janeiro Brazil
United States > US
Maryland
ISSN:1935-2735, 1935-2727, 1935-2735
Online-Zugang:Volltext
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Beschreibung
Zusammenfassung:The worldwide expansion of new emergent arboviruses such as Chikungunya and Zika reinforces the importance in understanding the role of mosquito species in spreading these pathogens in affected regions. This knowledge is essential for developing effective programs based on species specificity to avoid the establishment of endemic transmission cycles sustained by the identified local vectors. Although the first autochthonous transmission of Chikungunya virus was described in 2014 in the north of Brazil, the main outbreaks were reported in 2015 and 2016 in the northeast of Brazil. During 5 days of February 2016, we collected mosquitoes in homes of 6 neighborhoods of Aracaju city, the capital of Sergipe state. Four mosquito species were identified but Culex quinquefasciatus and Aedes aegypti were the most abundant. Field-caught mosquitoes were tested for Chikungunya (CHIKV), Zika (ZIKV) and Dengue viruses (DENV) by qRT-PCR and one CHIKV-infected Ae. aegypti female was detected. The complete sequence of CHIKV genome was obtained from this sample and phylogenetic analysis revealed that this isolate belongs to the East-Central-South-African (ECSA) genotype. Our study describes the first identification of a naturally CHIKV-infected Ae. aegypti in Brazil and the first report of a CHIKV from ECSA genotype identified in this species in the Americas. These findings support the notion of Ae. aegypti being a vector involved in CHIKV outbreaks in northeast of Brazil.
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Conceptualization: ALCS RSI VP AFL MPC MRW JTL KP GP PMAZ MLC.Data curation: ALCS RSI MPC.Formal analysis: ALCS RSI MPC MRW JTL KP GP.Funding acquisition: GP DDC LS PMAZ MLC.Investigation: ALCS RSI VP AFL.Methodology: ALCS RSI VP AFL MPC MRW JTL KP GP.Project administration: ALCS RSI.Resources: GP DDC LS PMAZ MLC.Supervision: PMAZ LS MLC.Validation: ALCS.Visualization: ALCS RSI VP MPC.Writing – original draft: ALCS RSI VP MPC.Writing – review & editing: MRW JTL LS PMAZ MLC.
The authors have declared that no competing interests exist.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0005630