Initiation of Antiretroviral Therapy (ART) at Different Stages of HIV-1 Disease Is Not Associated with the Proportion of Exhausted CD8+ T Cells

CD8+ T cell-restricted immunity is important in the control of HIV-1 infection, but continued immune activation results in CD8+ T cell dysfunction. Early initiation of antiretroviral treatment (ART) and the duration of ART have been associated with immune reconstitution. Here, we evaluated whether r...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 10; p. e0139573
Main Authors:	Jensen, Sanne Skov, Fomsgaard, Anders, Larsen, Tine Kochendorf, Tingstedt, Jeanette Linnea, Gerstoft, Jan, Kronborg, Gitte, Pedersen, Court, Karlsson, Ingrid
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.10.2015 Public Library of Science (PLoS)
Subjects:	Adult Aged Anti-HIV Agents - therapeutic use Antigens Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Case-Control Studies CD8 antigen CD8-Positive T-Lymphocytes - immunology Cell activation Cytometry Drug therapy Female Flow cytometry HIV HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - immunology Hospitals Human immunodeficiency virus Humans Immune reconstitution Immunity Immunology Infections Infectious diseases Interleukin 2 Laboratories Life assessment Lymphocytes Lymphocytes T Male Markers Middle Aged PD-1 protein Phenotypes R&D Research & development Restoration Seroconversion Studies T cell receptors Therapy Tumor necrosis factor-α Viral infections Viral Load - immunology Virology γ-Interferon Denmark
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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