What are the immunologically active components of Bacille Calmette‐Guérin in therapy of superficial bladder cancer?

The subcomponents of bacille Calmette‐Guérin (BCG) involved in the mechanism of action of intravesical BCG immunotherapy used for prophylaxis of superficial bladder cancer recurrences have been poorly investigated. We purified various BCG subcomponents and analyzed in vitro their ability to enhance...

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Bibliographic Details
Published in:	International journal of cancer Vol. 87; no. 6; pp. 844 - 852
Main Authors:	Zlotta, Alexandre R., Van Vooren, Jean‐Paul, Denis, Olivier, Drowart, Annie, Daffé, Mamadou, Lefèvre, Pascal, Schandene, Liliane, De Cock, Michel, De Bruyn, Jacqueline, Vandenbussche, Paul, Jurion, Fabienne, Palfliet, Kamille, Simon, Jacques, Schulman, Claude C., Content, Jean, Huygen, Kris
Format:	Journal Article
Language:	English
Published:	New York John Wiley & Sons, Inc 15.09.2000 Wiley-Liss
Subjects:	Antigens, Bacterial - analysis Antigens, Bacterial - immunology Antigens, CD - biosynthesis Antineoplastic agents Bacterial Outer Membrane Proteins - physiology BCG Vaccine - immunology BCG Vaccine - therapeutic use Biological and medical sciences CD56 Antigen - biosynthesis Humans Immunotherapy Interferon-gamma - biosynthesis Interleukin-12 - biosynthesis Interleukin-2 - biosynthesis Interleukin-6 - biosynthesis Leukocytes, Mononuclear - metabolism Medical sciences Neoplasm Proteins - biosynthesis Pharmacology. Drug treatments Th1 Cells - immunology Tumor Cells, Cultured Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - therapy Human Urinary system disease Immune response BCG Th1 lymphocyte Helper cell Cytotoxicity Early stage Malignant tumor Urinary tract disease Transitional cell carcinoma In vitro Cell subpopulation Treatment Urinary bladder Immunotherapy Established cell line T-Lymphocyte Bladder disease Mechanism of action
ISSN:	0020-7136, 1097-0215
Online Access:	Get full text
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