A practical guide to the pharmacological and behavioral therapy of Narcolepsy

Narcolepsy is a rare, chronic, and disabling central nervous system hypersomnia; two forms can be recognized: narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Its etiology is still largely unknown, but studies have reported a strong association between NT1 and HLA, as well as a pathogenic associ...

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Vydané v:Neurotherapeutics Ročník 18; číslo 1; s. 6 - 19
Hlavní autori: Franceschini, Christian, Pizza, Fabio, Cavalli, Francesca, Plazzi, Giuseppe
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cham Elsevier Inc 01.01.2021
Springer International Publishing
Springer Nature B.V
Predmet:
Adults
Behavior modification
Behavior Therapy - methods
Behavioral treatment
Biomedical and Life Sciences
Biomedicine
Carbamates - therapeutic use
Central nervous system
Children
Cognitive ability
Cognitive behavioral therapy
Cognitive behavioral treatment
Counseling
Etiology
Humans
Hypothalamus
Modafinil - therapeutic use
Narcolepsy
Narcolepsy - drug therapy
Narcolepsy - psychology
Narcolepsy - therapy
Neurobiology
Neurology
Neurosciences
Neurosurgery
Neurotrophin 1
Neurotrophin 2
Orexins
Pediatrics
Pharmacological treatment
Phenylalanine - analogs & derivatives
Phenylalanine - therapeutic use
Piperidines - therapeutic use
Quality of life
Review
Sleep disorders
Wakefulness-Promoting Agents - therapeutic use
Well being
Pharmacological treatment
Cognitive behavioral treatment
Narcolepsy
Adults
Children
Behavioral treatment
ISSN:1878-7479, 1933-7213, 1878-7479
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Popis
Shrnutí:Narcolepsy is a rare, chronic, and disabling central nervous system hypersomnia; two forms can be recognized: narcolepsy type 1 (NT1) and narcolepsy type 2 (NT2). Its etiology is still largely unknown, but studies have reported a strong association between NT1 and HLA, as well as a pathogenic association with the deficiency of cerebrospinal hypocretin-1. Thus, the most reliable pathogenic hypothesis is an autoimmune process destroying hypothalamic hypocretin-producing cells. A definitive cure for narcolepsy is not available to date, and although the research in the field is highly promising, up to now, current treatments have aimed to reduce the symptoms by means of different pharmacological approaches. Moreover, overall narcolepsy symptoms management can also benefit from non-pharmacological approaches such as cognitive behavioral therapies (CBTs) and psychosocial interventions to improve the patients' quality of life in both adult and pediatric-affected individuals as well as the well-being of their families. In this review, we summarize the available therapeutic options for narcolepsy, including the pharmacological, behavioral, and psychosocial interventions.
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ISSN:1878-7479
1933-7213
1878-7479
DOI:10.1007/s13311-021-01051-4