Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance

Breast Cancer Type 1 Susceptibility Protein (BRCA1)-deficient cells have compromised DNA repair and are sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. Despite initial responses, the development of resistance limits clinical efficacy. Mutations in the BRCA C-terminal (BRCT) domain of BRC...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 110; číslo 42; s. 17041
Hlavní autori:	Johnson, Neil, Johnson, Shawn F, Yao, Wei, Li, Yu-Chen, Choi, Young-Eun, Bernhardy, Andrea J, Wang, Yifan, Capelletti, Marzia, Sarosiek, Kristopher A, Moreau, Lisa A, Chowdhury, Dipanjan, Wickramanayake, Anneka, Harrell, Maria I, Liu, Joyce F, D'Andrea, Alan D, Miron, Alexander, Swisher, Elizabeth M, Shapiro, Geoffrey I
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 15.10.2013
Predmet:	Antineoplastic Agents - pharmacology Benzoquinones - pharmacology BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 Protein - genetics BRCA2 Protein - metabolism Cell Line, Tumor Cisplatin - pharmacology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Fanconi Anemia Complementation Group N Protein Female HSP90 Heat-Shock Proteins - antagonists & inhibitors HSP90 Heat-Shock Proteins - genetics HSP90 Heat-Shock Proteins - metabolism Humans Lactams, Macrocyclic - pharmacology Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Platinum - pharmacology Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism Protein Structure, Tertiary Rad51 Recombinase - genetics Rad51 Recombinase - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism homologous recombination cancer therapy
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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