Regulation of cancer metastasis by cell-free miRNAs

MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circula...

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Published in:Biochimica et biophysica acta Vol. 1855; no. 1; pp. 24 - 42
Main Authors: Alečković, Maša, Kang, Yibin
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.01.2015
Subjects:
Animals
Biomarker
Body fluids
Cell-free microRNA
Cell-Free System
Exosomes
Exosomes - genetics
Exosomes - metabolism
Humans
Metastasis
MicroRNAs - blood
MicroRNAs - metabolism
MicroRNAs - physiology
Molecular Targeted Therapy - methods
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasm Metastasis - therapy
RISC
TAM
Biomarker
qRT-PCR
Metastasis
Exosomes
EMT
ECM
Body fluids
CSC
UTR
CTC
miR
cfNA
miRNA
NGS
MET
Cell-free microRNA
ISSN:0304-419X, 0006-3002, 1879-2561
Online Access:Get full text
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Abstract MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression. •Cell-free miRNAs have been detected in various body fluids of cancer patients.•Levels of specific miRNAs change in metastatic compared non-metastatic patients.•These could be used for diagnosis, prognosis and treatment of metastasis.•The functional role of several cell-free miRNAs in metastasis has been investigated.
AbstractList MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression. •Cell-free miRNAs have been detected in various body fluids of cancer patients.•Levels of specific miRNAs change in metastatic compared non-metastatic patients.•These could be used for diagnosis, prognosis and treatment of metastasis.•The functional role of several cell-free miRNAs in metastasis has been investigated.
MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression.MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression.
MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer initiation and metastatic progression, both by promoting and suppressing metastasis. Recently, cell-free miRNAs shed from cancer cells into circulation have been reported in cancer patients, raising hope for development of novel biomarkers that can be routinely measured in easily accessible samples. In fact, establishing miRNA expression in the circulation likely has advantages over determination in primary tumor tissue, further augmenting the potential applications of miRNA detection in oncological practice. In addition, secretion of miRNAs impacting distant cell signaling or promoting the formation of a niche that sustains a distant tumor microenvironment allows for new treatment approaches to thwart cancer progression.
Author Alečković, Maša
Kang, Yibin
Author_xml – sequence: 1
  givenname: Maša
  surname: Alečković
  fullname: Alečković, Maša
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  givenname: Yibin
  surname: Kang
  fullname: Kang, Yibin
  email: ykang@princeton.edu
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25450578$$D View this record in MEDLINE/PubMed
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Issue 1
Keywords RISC
TAM
Biomarker
qRT-PCR
Metastasis
Exosomes
EMT
ECM
Body fluids
CSC
UTR
CTC
miR
cfNA
miRNA
NGS
MET
Cell-free microRNA
Language English
License Copyright © 2014 Elsevier B.V. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c525t-bcb757373866aba85e24406fdead4d8bb9ab43b0b7d37f8b96fda24b6a2cd1623
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SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/4312713
PMID 25450578
PQID 1697209079
PQPubID 23479
PageCount 19
ParticipantIDs proquest_miscellaneous_1697209079
pubmed_primary_25450578
crossref_citationtrail_10_1016_j_bbcan_2014_10_005
crossref_primary_10_1016_j_bbcan_2014_10_005
elsevier_sciencedirect_doi_10_1016_j_bbcan_2014_10_005
PublicationCentury 2000
PublicationDate 2015-01-01
PublicationDateYYYYMMDD 2015-01-01
PublicationDate_xml – month: 01
  year: 2015
  text: 2015-01-01
  day: 01
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Biochimica et biophysica acta
PublicationTitleAlternate Biochim Biophys Acta
PublicationYear 2015
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
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Snippet MicroRNAs (miRNAs) are integral molecules in the regulation of numerous physiological cellular processes that have emerged as critical players in cancer...
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SubjectTerms Animals
Biomarker
Body fluids
Cell-free microRNA
Cell-Free System
Exosomes
Exosomes - genetics
Exosomes - metabolism
Humans
Metastasis
MicroRNAs - blood
MicroRNAs - metabolism
MicroRNAs - physiology
Molecular Targeted Therapy - methods
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasm Metastasis - therapy
Title Regulation of cancer metastasis by cell-free miRNAs
URI https://dx.doi.org/10.1016/j.bbcan.2014.10.005
https://www.ncbi.nlm.nih.gov/pubmed/25450578
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