Whole genome sequencing reveals novel resistance-conferring mutations and large genome deletions in drug-resistant Mycobacterium tuberculosis isolates from Indonesia

•Novel mutations were identified in drug-resistant M. tuberculosis isolates in Indonesia.•Large genome deletions conferring isoniazid resistance were also identified.•Pre-existing mutations resistant to new and repurposed oral drugs were not detected. This study evaluated drug resistance profiles of...

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Bibliographic Details
Published in:	Journal of Global Antimicrobial Resistance Vol. 44; pp. 314 - 318
Main Authors:	Aung, Htin Lin, Chaidir, Lidya, Pitaloka, Dian Ayu Eka, Miyahara, Yugen, Kumar, Narender, Soeroto, Arto Yuwono, Cook, Greg M, van Crevel, Reinout, Alisjahbana, Bachti, Peacock, Sharon J., Hill, Philip C
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.09.2025 Elsevier
Subjects:	Antitubercular Agents - pharmacology Bacterial Proteins - genetics Catalase - genetics Drug Resistance, Multiple, Bacterial - genetics GeneXpert Genome, Bacterial Humans Indonesia Infectious Disease Isoniazid - pharmacology MDR-TB Microbial Sensitivity Tests Mutation Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Novel mutations Rifampin - pharmacology Sequence Deletion Tuberculosis Tuberculosis, Multidrug-Resistant - microbiology WGS Whole Genome Sequencing Indonesia WGS Tuberculosis Whole genome sequencing Novel mutations MDR-TB GeneXpert Indonesia
ISSN:	2213-7165, 2213-7173, 2213-7165, 2213-7173
Online Access:	Get full text
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