MIR106B and MIR93 prevent removal of bacteria from epithelial cells by disrupting ATG16L1-mediated autophagy

Variants in genes that regulate autophagy have been associated with Crohn's disease (CD). Defects in autophagy-mediated removal of pathogenic microbes could contribute to the pathogenesis of CD. We investigated the role of the microRNAs (miRs) MIR106B and MIR93 in induction of autophagy and bac...

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Vydané v:	Gastroenterology (New York, N.Y. 1943) Ročník 146; číslo 1; s. 188
Hlavní autori:	Lu, Changming, Chen, Jianfeng, Xu, Hua-Guo, Zhou, Xianzheng, He, Qiongqiong, Li, Yu-Lin, Jiang, Guoqing, Shan, Yuxi, Xue, Boxin, Zhao, Rui-Xun, Wang, Yong, Werle, Kaitlin D, Cui, Rutao, Liang, Jiyong, Xu, Zhi-Xiang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.01.2014
Predmet:	Autophagy - genetics Autophagy - immunology Autophagy-Related Proteins Carrier Proteins - immunology Case-Control Studies Cell Line, Tumor Crohn Disease - genetics Crohn Disease - immunology DEAD-box RNA Helicases - immunology Epithelial Cells - immunology Escherichia coli HCT116 Cells HeLa Cells Humans Intestinal Mucosa - immunology Intestinal Mucosa - metabolism MicroRNAs - genetics MicroRNAs - immunology Proto-Oncogene Proteins c-myc - immunology Proto-Oncogene Proteins c-myc - metabolism Ribonuclease III - immunology IHC mRNA small interfering RNA GFP UTR miRNA/miR messenger RNA FBS AIEC Inflammatory Bowel Disease immunohistochemistry LC3 CD light chain 3 Baf adherent-invasive Escherichia coli IRGM1 untranslated region Crohn's disease siRNA green fluorescent protein Cell Biology Infection fetal bovine serum ATG bafilomycin autophagy-related gene Glyceraldehyde-3-phosphate dehydrogenase microRNA GAPDH immunity-related guanosine triphosphatase family M protein 1
ISSN:	1528-0012, 1528-0012
On-line prístup:	Zistit podrobnosti o prístupe
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