Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and contributes to the control of secondary infections. However, little is known about how tissue-resident memory T cells behave in situ and how they enco...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 109; H. 48; S. 19739
Hauptverfasser: Ariotti, Silvia, Beltman, Joost B, Chodaczek, Grzegorz, Hoekstra, Mirjam E, van Beek, Anna E, Gomez-Eerland, Raquel, Ritsma, Laila, van Rheenen, Jacco, Marée, Athanasius F M, Zal, Tomasz, de Boer, Rob J, Haanen, John B A G, Schumacher, Ton N
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 27.11.2012
Schlagworte:
Antigens - immunology
CD8-Positive T-Lymphocytes - immunology
Epithelium - immunology
Humans
Immunologic Memory
ISSN:1091-6490, 1091-6490
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Zusammenfassung:Recent work has demonstrated that following the clearance of infection a stable population of memory T cells remains present in peripheral organs and contributes to the control of secondary infections. However, little is known about how tissue-resident memory T cells behave in situ and how they encounter newly infected target cells. Here we demonstrate that antigen-specific CD8(+) T cells that remain in skin following herpes simplex virus infection show a steady-state crawling behavior in between keratinocytes. Spatially explicit simulations of the migration of these tissue-resident memory T cells indicate that the migratory dendritic behavior of these cells allows the detection of antigen-expressing target cells in physiologically relevant time frames of minutes to hours. Furthermore, we provide direct evidence for the identification of rare antigen-expressing epithelial cells by skin-patrolling memory T cells in vivo. These data demonstrate the existence of skin patrol by memory T cells and reveal the value of this patrol in the rapid detection of renewed infections at a previously infected site.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.1208927109