Cholestyramine Influences Meal-Stimulated Pancreaticobiliary Function and Plasma Cholecystokinin Independent of Gastric Emptying and Food Digestion

Background: Cholestyramine enhances gallbladder emptying and plasma cholecystokinin responses to oral ingestion of a mixed meal. It is not known whether this effect occurs independently of alterations in gastric emptying or maldigestion of nutrients. Methods: We perfused 15 g of an amino acid meal i...

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Vydáno v:	Scand J Gastroenterol Ročník 32; číslo 8; s. 778 - 784
Hlavní autoři:	Thimister, P. W. L., Hopman, W. P. M., Loualidi, A., Rosenbusch, G., Willems, H. L., Trijbels, F. J. M., Jansen, J. B. M. J.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Copenhagen Informa UK Ltd 1997 Oslo Taylor & Francis Stockholm Informa UK Limited Scandinavian University Press
Témata:	Adult Amino Acids Amino Acids - administration & dosage Amylases Amylases - drug effects Amylases - secretion Animals Anticholesteremic Agents Anticholesteremic Agents - administration & dosage Biochemical Phenomena, Metabolism, Nutrition (Non MeSH) Biological and medical sciences Biological Sciences Biomedical Magnetic Resonance Biomedische Magnetische Resonantie Body Regions (Non MeSH) Brain Mapping Cardiovascular Diseases Cardiovascular System Cholecystokinin Cholecystokinin - blood Cholecystokinin - drug effects Cholestyramine Resin Cholestyramine Resin - administration & dosage Circulatory, Respiratory Physiology (Non MeSH) Consumption, Saving, Production, Employment, and Investment Corporate Finance and Governance Data Collection and Data Estimation Methodology; Computer Programs Design of Experiments Diagnosis Digestion Digestion - drug effects Digestive System Digestive System Diseases Eating Eating - physiology Econometric and Statistical Methods: Special Topics Econometric Methods: Single Equation Models Econometric Modeling Endocrine Diseases Endocrine System (Non MeSH) Environment and Public Health (Non MeSH) Estimation Female Female Genital Diseases and Pregnancy Complications (Non MeSH) Financial Institutions and Services Fluids and Secretions (Non MeSH) Gallbladder Emptying Gallbladder Emptying - drug effects gallbladder motility Game Theory and Bargaining Theory Gastric Emptying Gastric Emptying - drug effects General Aggregative Models General Economics General Financial Markets General pharmacology Health Occupations Humans Hypothesis Testing Male Mathematical Methods and Programming Medical sciences Models with Panel Data Musculoskeletal Diseases Musculoskeletal System Musculoskeletal, Neural, Eye Physiology (Non MeSH) Neonatal Diseases and Abnormalities (Non MeSH) Neoplasms Nervous System Nervous System Diseases Nutrition, secretion and motility Nutritional and Metabolic Diseases (Non MeSH) Other Otorhinolaryngologic Diseases pancreatic enzyme secretion Pancreatic Polypeptide Pancreatic Polypeptide - blood Pancreatic Polypeptide - drug effects Phantoms, Imaging Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments Physiology, General (Non MeSH) Portfolio Choice Radioimmunoassay Reference Values Relation of Economics to Other Disciplines Respiratory System Respiratory Tract Diseases Semiparametric and Nonparametric Methods Sodium Chloride Sodium Chloride - administration & dosage Stomatognathic Diseases Symptoms and General Pathology (Non MeSH) Teaching of Economics Technology, Radiologic Therapeutics Tissue Types (Non MeSH) Tomography Scanners, X-Ray Computed Urogenital System Urologic and Male Genital Diseases (Non MeSH) Virus Diseases Voeding, secretie en motoriek X-Ray Intensifying Screens Human Biliary tract Colestyramine Digestive system Postprandial Gastric emptying Pharmacology Chemotherapy Uncertainty relation Physiology Cholecystokinin Biological effect Exocrine secretion Pancreas Motricity Antilipemic agent
ISSN:	0036-5521, 1502-7708
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Shrnutí:	Background: Cholestyramine enhances gallbladder emptying and plasma cholecystokinin responses to oral ingestion of a mixed meal. It is not known whether this effect occurs independently of alterations in gastric emptying or maldigestion of nutrients. Methods: We perfused 15 g of an amino acid meal intraduodenally for 60min in seven healthy volunteers, once with and once without cholestyramine. Intraduodenal perfusion of saline with or without cholestyramine (6 g/h) was started 60 min before the amino acid meal and continued for 2 h. Results: Cholestyramine markedly enhanced the incremental plasma cholecystokinin response to the meal from 36 ±12 to 139 ± 25 pmol/1 60 min (P < 0.005), incremental amylase output from 2.4 ± 0.7 to 5.7 ± 0.7 kU/h (P < 0.05), and incremental integrated gallbladder contraction from1948 ± 235 to 2840 ± 189% 60 min (P < 0.05). Conclusion: The enhancing effect of cholestyramine on postprandial gallbladder contraction, pancreatic enzyme secretion, and plasma cholecystokinin release is not dependent on gastric emptying rates or appropriate digestion of nutrients.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3
ISSN:	0036-5521 1502-7708
DOI:	10.3109/00365529708996534