Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson's Disease

Long noncoding RNAs (lncRNAs) are implicated in the autophagic-lysosomal pathway (ALP) and are closely linked to Parkinson's disease (PD) pathology. β-Glucocerebrosidase (GCase) has also been reported to be correlated with α-synuclein (α-syn) proteostasis. However, lncRNAs and α-syn in neural-d...

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Veröffentlicht in:	Neurotherapeutics Jg. 17; H. 3; S. 1104 - 1119
Hauptverfasser:	Zou, Jing, Guo, Yue, Wei, Lei, Yu, Fang, Yu, Bo, Xu, Anding
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Cham Elsevier Inc 01.07.2020 Springer International Publishing Springer Nature B.V
Schlagworte:	Aged alpha-Synuclein - blood Autophagic-lysosomal pathway Biomarkers - blood Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Cognitive ability Cross-Sectional Studies Enzyme Activation - physiology Exosomes Exosomes - metabolism Female Glucosylceramidase Glucosylceramidase - blood Glucosylceramidase - metabolism Humans L1CAM exosomes Linc-POU3F3 Male Middle Aged Movement disorders Nanoparticles Neural Cell Adhesion Molecule L1 - blood Neurobiology Neurodegenerative diseases Neurology Neurosciences Neurosurgery Original Original Article Parkinson Disease - blood Parkinson Disease - diagnosis Parkinson's disease POU Domain Factors - blood Predictive Value of Tests Ribonucleic acid RNA Synuclein α-synuclein Linc-POU3F3 Autophagic-lysosomal pathway Parkinson's disease L1CAM exosomes α-synuclein Parkinson’s disease
ISSN:	1878-7479, 1933-7213, 1878-7479
Online-Zugang:	Volltext
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