Lipidome Evolution in Mammalian Tissues

Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While c...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Molecular biology and evolution Ročník 35; číslo 8; s. 1947 - 1957
Hlavní autori: Khrameeva, Ekaterina, Kurochkin, Ilia, Bozek, Katarzyna, Giavalisco, Patrick, Khaitovich, Philipp
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States Oxford University Press 01.08.2018
Predmet:
Annotations
Bats
Biology
Clusters
Cognitive ability
Consignment buying
Discoveries
Evolution
Evolution & development
Gene expression
Genomes
Genotype & phenotype
Lipid composition
Lipids
Mass spectrometry
Metabolites
Phylogenetics
Scientific imaging
Structure-function relationships
ISSN:0737-4038, 1537-1719, 1537-1719
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Popis
Shrnutí:Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Article-2
ObjectType-Feature-1
content type line 23
Ekaterina Khrameeva and Ilia Kurochkin contributed equally to this work.
ISSN:0737-4038
1537-1719
1537-1719
DOI:10.1093/molbev/msy097