Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors
Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival in a population-based cohort. The study included 38,060 patients with hematologi...
Saved in:
| Published in: | Journal of clinical oncology Vol. 31; no. 19; p. 2437 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
01.07.2013
|
| Subjects: | |
| ISSN: | 1527-7755, 1527-7755 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival in a population-based cohort.
The study included 38,060 patients with hematologic malignancies or disorders who underwent first alloHCT in a US or Canadian center from 1994 to 2005 and were reported to the Center for International Blood and Marrow Transplant Research.
AlloHCT as treatment for acute lymphoblastic (ALL) and myeloid leukemias (AML), myelodysplastic syndrome (MDS), and Hodgkin and non-Hodgkin lymphomas increased by 45%, from 2,520 to 3,668 patients annually. From 1994 to 2005, use of both peripheral (7% to 63%) [corrected] and cord blood increased (2% to 10%), whereas use of marrow decreased (90% to 27%). Despite a median age increase from 33 to 40 years and 165% [corrected] increase in unrelated donors for alloHCT, overall survival (OS) at day 100 significantly improved for patients with AML in first complete remission after myeloablative sibling alloHCT (85% to 94%; P < .001) and unrelated alloHCT (63% to 86%; P < .001); 1-year OS improved among those undergoing unrelated alloHCT (48% to 63%; P = .003) but not among those undergoing sibling alloHCT. Similar results were seen for ALL and MDS. Day-100 OS after cord blood alloHCT improved significantly from 60% to 78% (P < .001) for AML, ALL, MDS, and chronic myeloid leukemia. Use of reduced-intensity regimens increased, yielding OS rates similar to those of myeloablative regimens.
Survival for those undergoing alloHCT has significantly improved over time. However, new approaches are needed to further improve 1-year OS. |
|---|---|
| AbstractList | Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival in a population-based cohort.PURPOSEOver the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival in a population-based cohort.The study included 38,060 patients with hematologic malignancies or disorders who underwent first alloHCT in a US or Canadian center from 1994 to 2005 and were reported to the Center for International Blood and Marrow Transplant Research.PATIENTS AND METHODSThe study included 38,060 patients with hematologic malignancies or disorders who underwent first alloHCT in a US or Canadian center from 1994 to 2005 and were reported to the Center for International Blood and Marrow Transplant Research.AlloHCT as treatment for acute lymphoblastic (ALL) and myeloid leukemias (AML), myelodysplastic syndrome (MDS), and Hodgkin and non-Hodgkin lymphomas increased by 45%, from 2,520 to 3,668 patients annually. From 1994 to 2005, use of both peripheral (7% to 63%) [corrected] and cord blood increased (2% to 10%), whereas use of marrow decreased (90% to 27%). Despite a median age increase from 33 to 40 years and 165% [corrected] increase in unrelated donors for alloHCT, overall survival (OS) at day 100 significantly improved for patients with AML in first complete remission after myeloablative sibling alloHCT (85% to 94%; P < .001) and unrelated alloHCT (63% to 86%; P < .001); 1-year OS improved among those undergoing unrelated alloHCT (48% to 63%; P = .003) but not among those undergoing sibling alloHCT. Similar results were seen for ALL and MDS. Day-100 OS after cord blood alloHCT improved significantly from 60% to 78% (P < .001) for AML, ALL, MDS, and chronic myeloid leukemia. Use of reduced-intensity regimens increased, yielding OS rates similar to those of myeloablative regimens.RESULTSAlloHCT as treatment for acute lymphoblastic (ALL) and myeloid leukemias (AML), myelodysplastic syndrome (MDS), and Hodgkin and non-Hodgkin lymphomas increased by 45%, from 2,520 to 3,668 patients annually. From 1994 to 2005, use of both peripheral (7% to 63%) [corrected] and cord blood increased (2% to 10%), whereas use of marrow decreased (90% to 27%). Despite a median age increase from 33 to 40 years and 165% [corrected] increase in unrelated donors for alloHCT, overall survival (OS) at day 100 significantly improved for patients with AML in first complete remission after myeloablative sibling alloHCT (85% to 94%; P < .001) and unrelated alloHCT (63% to 86%; P < .001); 1-year OS improved among those undergoing unrelated alloHCT (48% to 63%; P = .003) but not among those undergoing sibling alloHCT. Similar results were seen for ALL and MDS. Day-100 OS after cord blood alloHCT improved significantly from 60% to 78% (P < .001) for AML, ALL, MDS, and chronic myeloid leukemia. Use of reduced-intensity regimens increased, yielding OS rates similar to those of myeloablative regimens.Survival for those undergoing alloHCT has significantly improved over time. However, new approaches are needed to further improve 1-year OS.CONCLUSIONSurvival for those undergoing alloHCT has significantly improved over time. However, new approaches are needed to further improve 1-year OS. Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases. This study describes changes in use, technique, and survival in a population-based cohort. The study included 38,060 patients with hematologic malignancies or disorders who underwent first alloHCT in a US or Canadian center from 1994 to 2005 and were reported to the Center for International Blood and Marrow Transplant Research. AlloHCT as treatment for acute lymphoblastic (ALL) and myeloid leukemias (AML), myelodysplastic syndrome (MDS), and Hodgkin and non-Hodgkin lymphomas increased by 45%, from 2,520 to 3,668 patients annually. From 1994 to 2005, use of both peripheral (7% to 63%) [corrected] and cord blood increased (2% to 10%), whereas use of marrow decreased (90% to 27%). Despite a median age increase from 33 to 40 years and 165% [corrected] increase in unrelated donors for alloHCT, overall survival (OS) at day 100 significantly improved for patients with AML in first complete remission after myeloablative sibling alloHCT (85% to 94%; P < .001) and unrelated alloHCT (63% to 86%; P < .001); 1-year OS improved among those undergoing unrelated alloHCT (48% to 63%; P = .003) but not among those undergoing sibling alloHCT. Similar results were seen for ALL and MDS. Day-100 OS after cord blood alloHCT improved significantly from 60% to 78% (P < .001) for AML, ALL, MDS, and chronic myeloid leukemia. Use of reduced-intensity regimens increased, yielding OS rates similar to those of myeloablative regimens. Survival for those undergoing alloHCT has significantly improved over time. However, new approaches are needed to further improve 1-year OS. |
| Author | McCarthy, Jr, Philip L Hale, Gregory A Lazarus, Hillard M Rizzo, J Douglas Parsons, Susan Isola, Luis M Maziarz, Richard T Majhail, Navneet S Hahn, Theresa Loberiza, Fausto Joffe, Steven Bredeson, Christopher Lee, Stephanie J Hassebroek, Anna Gajewski, James L Lemaistre, Charles F |
| Author_xml | – sequence: 1 givenname: Theresa surname: Hahn fullname: Hahn, Theresa organization: National Marrow Donor Program, Minneapolis, MN 55413, USA – sequence: 2 givenname: Philip L surname: McCarthy, Jr fullname: McCarthy, Jr, Philip L – sequence: 3 givenname: Anna surname: Hassebroek fullname: Hassebroek, Anna – sequence: 4 givenname: Christopher surname: Bredeson fullname: Bredeson, Christopher – sequence: 5 givenname: James L surname: Gajewski fullname: Gajewski, James L – sequence: 6 givenname: Gregory A surname: Hale fullname: Hale, Gregory A – sequence: 7 givenname: Luis M surname: Isola fullname: Isola, Luis M – sequence: 8 givenname: Hillard M surname: Lazarus fullname: Lazarus, Hillard M – sequence: 9 givenname: Stephanie J surname: Lee fullname: Lee, Stephanie J – sequence: 10 givenname: Charles F surname: Lemaistre fullname: Lemaistre, Charles F – sequence: 11 givenname: Fausto surname: Loberiza fullname: Loberiza, Fausto – sequence: 12 givenname: Richard T surname: Maziarz fullname: Maziarz, Richard T – sequence: 13 givenname: J Douglas surname: Rizzo fullname: Rizzo, J Douglas – sequence: 14 givenname: Steven surname: Joffe fullname: Joffe, Steven – sequence: 15 givenname: Susan surname: Parsons fullname: Parsons, Susan – sequence: 16 givenname: Navneet S surname: Majhail fullname: Majhail, Navneet S |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23715573$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUU1vFDEMjVARbRfunFCOHLrbfE5mjmgFbVGlHoDzypt4lqBMMiSZlfrP-vPIQhGc_Gw_vyfbl-QspoiEvOVswwVj15-3DxvBuNiobtPxQb4gF1wLszZG67P_8Dm5LOUHY1z1Ur8i50IarrWRF-Tpiz9EP3oLsVI_zTkdccITjrQs-eiPECiMFTOFENIBI3pLv-MENc3JY22ZxRBozRDLHJoMVJ8idUv28UCBzph9cjSNtPyzCo_NwGaEgo4uBa9oCq55ZLR-9id_OLQixN_d0_ASMwaoje5STLm8Ji9HCAXfPMcV-fbp49ft7fr-4eZu--F-bbVQdT2ClsracdB7pRgaoaQYcOjQdb3SlnXOMjXwveYOjEHRc-h4Qx30Yy87LVbk_R_ddpqfC5a6m3w5bQwR01J2XBqp5GDaF1bk3TN12U_odnP2E-TH3d9ri1-zR4gX |
| CitedBy_id | crossref_primary_10_1016_j_bbmt_2015_07_016 crossref_primary_10_1016_j_jtct_2021_05_028 crossref_primary_10_1038_bmt_2015_148 crossref_primary_10_1016_j_ejmech_2018_12_042 crossref_primary_10_1007_s00277_015_2338_7 crossref_primary_10_1371_journal_pone_0190610 crossref_primary_10_1007_s11654_018_0078_6 crossref_primary_10_1111_bjh_16354 crossref_primary_10_1186_s12885_022_10096_3 crossref_primary_10_1089_jpm_2019_0611 crossref_primary_10_32635_2176_9745_RBC_2024v70n3_4733 crossref_primary_10_1053_j_seminhematol_2016_01_010 crossref_primary_10_1097_MOH_0000000000000119 crossref_primary_10_1007_s00066_022_01914_5 crossref_primary_10_1016_j_tmrv_2016_06_002 crossref_primary_10_1038_s41409_019_0654_6 crossref_primary_10_1016_j_bbmt_2016_03_008 crossref_primary_10_1517_13543784_2014_876407 crossref_primary_10_1186_s13045_016_0295_9 crossref_primary_10_1016_j_hoc_2014_08_014 crossref_primary_10_1016_j_jtct_2021_05_024 crossref_primary_10_1016_j_hoc_2014_08_016 crossref_primary_10_1038_s41409_019_0748_1 crossref_primary_10_1016_j_bbmt_2014_10_021 crossref_primary_10_1016_j_bbmt_2016_10_020 crossref_primary_10_1016_j_jgo_2014_04_004 crossref_primary_10_1016_j_beha_2023_101475 crossref_primary_10_1517_14740338_2016_1161020 crossref_primary_10_1038_s41409_021_01539_9 crossref_primary_10_1002_cncr_30737 crossref_primary_10_1007_s00277_020_04051_0 crossref_primary_10_1007_s11899_014_0220_7 crossref_primary_10_1038_s41598_019_56322_0 crossref_primary_10_1182_bloodadvances_2018029421 crossref_primary_10_1038_bmt_2014_114 crossref_primary_10_1002_ajh_25705 crossref_primary_10_1016_j_bbmt_2017_03_014 crossref_primary_10_1007_s11839_016_0559_1 crossref_primary_10_1038_s41598_022_18553_6 crossref_primary_10_1016_j_bbmt_2020_05_006 crossref_primary_10_1007_s11914_013_0180_1 crossref_primary_10_1016_j_bbmt_2014_10_027 crossref_primary_10_1038_s41409_022_01683_w crossref_primary_10_1002_ajh_24285 crossref_primary_10_1016_j_bbmt_2015_02_014 crossref_primary_10_1016_j_actbio_2016_08_054 crossref_primary_10_5858_arpa_2014_0230_RS crossref_primary_10_1016_j_blre_2025_101329 crossref_primary_10_1016_j_transci_2020_102743 crossref_primary_10_1182_blood_2017_07_795948 crossref_primary_10_1016_j_bbmt_2015_05_021 crossref_primary_10_1016_j_bbmt_2018_11_018 crossref_primary_10_2217_fon_2016_0443 crossref_primary_10_1016_j_bbmt_2015_07_032 crossref_primary_10_1038_s41379_019_0203_2 crossref_primary_10_1038_s41409_023_02109_x crossref_primary_10_1097_MOH_0000000000000016 crossref_primary_10_1007_s40266_018_0596_5 crossref_primary_10_1182_blood_2018_04_844738 crossref_primary_10_1016_j_bbmt_2018_01_016 crossref_primary_10_1016_j_bbmt_2020_03_002 crossref_primary_10_1016_j_bbmt_2020_03_005 crossref_primary_10_1038_bmt_2015_166 crossref_primary_10_1016_j_bbmt_2014_11_008 crossref_primary_10_1038_s41598_018_24060_4 crossref_primary_10_1016_j_bbmt_2014_07_007 crossref_primary_10_1016_j_bbmt_2017_01_001 crossref_primary_10_1182_bloodadvances_2023010598 crossref_primary_10_1038_s41375_025_02724_1 crossref_primary_10_1111_imj_12456 crossref_primary_10_1038_bmt_2016_259 crossref_primary_10_1097_TP_0000000000002693 crossref_primary_10_1111_trf_13534 crossref_primary_10_1155_2014_701013 crossref_primary_10_1038_bmt_2016_135 crossref_primary_10_1002_ncp_10808 crossref_primary_10_1188_15_ONF_265_275 crossref_primary_10_1016_j_bbmt_2018_03_016 crossref_primary_10_1038_s41409_021_01491_8 crossref_primary_10_1186_s12885_021_07897_3 crossref_primary_10_1200_JCO_2014_55_1564 crossref_primary_10_1016_j_bbmt_2014_03_013 crossref_primary_10_1038_s41375_018_0185_y crossref_primary_10_1016_j_bbmt_2015_09_008 crossref_primary_10_1097_MOH_0000000000000026 crossref_primary_10_1007_s00277_024_05944_0 crossref_primary_10_1038_leu_2015_188 crossref_primary_10_1111_bjh_18905 crossref_primary_10_1053_j_seminhematol_2018_04_013 crossref_primary_10_1111_ejh_12739 crossref_primary_10_1097_TP_0000000000001257 crossref_primary_10_1016_j_jgo_2019_05_022 crossref_primary_10_1182_bloodadvances_2023012469 crossref_primary_10_1111_joim_12854 crossref_primary_10_1007_s40266_015_0312_7 crossref_primary_10_3389_fped_2023_1247792 crossref_primary_10_1016_j_bbmt_2018_04_008 crossref_primary_10_1080_10428194_2020_1742909 crossref_primary_10_1002_psp4_12486 crossref_primary_10_1111_joim_12695 crossref_primary_10_1371_journal_pone_0209800 crossref_primary_10_1002_cncr_28631 crossref_primary_10_1007_s11899_014_0246_x crossref_primary_10_3324_haematol_2024_285002 crossref_primary_10_1016_j_bbmt_2013_12_001 crossref_primary_10_1038_s41409_021_01274_1 crossref_primary_10_1002_cncr_31249 crossref_primary_10_1002_cncr_30031 crossref_primary_10_1038_bmt_2017_115 crossref_primary_10_1007_s11912_018_0679_9 crossref_primary_10_1182_blood_2017_11_817973 crossref_primary_10_1016_S2352_3026_19_30158_9 crossref_primary_10_1002_hon_3241 crossref_primary_10_1007_s40291_022_00618_x crossref_primary_10_1038_s41375_023_01840_0 crossref_primary_10_3390_ijms23168905 crossref_primary_10_1016_j_cll_2025_01_014 crossref_primary_10_1016_j_jgo_2019_11_008 crossref_primary_10_1016_j_bbmt_2020_08_027 crossref_primary_10_3389_fmed_2023_1133381 crossref_primary_10_1155_2021_5568513 crossref_primary_10_1038_bmt_2014_152 crossref_primary_10_1007_s40266_015_0309_2 crossref_primary_10_1016_j_jtct_2022_08_024 crossref_primary_10_1111_bcp_14256 crossref_primary_10_1177_1078155216637216 crossref_primary_10_1007_s10875_023_01465_z crossref_primary_10_1016_j_bbmt_2016_08_018 crossref_primary_10_3109_0284186X_2015_1115124 crossref_primary_10_1177_2040620717741860 crossref_primary_10_1016_j_jtct_2022_09_015 crossref_primary_10_1016_j_clml_2019_11_008 crossref_primary_10_1080_10428194_2024_2365910 crossref_primary_10_1186_s13045_015_0207_4 crossref_primary_10_1007_s11899_014_0234_1 crossref_primary_10_1080_16078454_2024_2347673 crossref_primary_10_1007_s00277_021_04661_2 crossref_primary_10_1016_j_bbmt_2018_09_042 crossref_primary_10_1200_JCO_2014_57_8195 crossref_primary_10_1016_j_jtct_2025_08_019 crossref_primary_10_1016_j_ejon_2016_01_001 crossref_primary_10_1007_s11899_014_0211_8 crossref_primary_10_1016_j_cger_2015_08_010 crossref_primary_10_1111_bjh_70099 crossref_primary_10_1200_JCO_2013_52_0296 crossref_primary_10_1038_bmt_2016_34 crossref_primary_10_1182_bloodadvances_2018028241 crossref_primary_10_1016_j_jcyt_2024_03_489 crossref_primary_10_1097_HS9_0000000000000704 crossref_primary_10_1016_j_bbmt_2018_08_004 crossref_primary_10_1111_petr_12536 crossref_primary_10_1182_bloodadvances_2021006300 crossref_primary_10_1016_j_bbmt_2016_01_013 crossref_primary_10_1016_j_beha_2014_11_006 crossref_primary_10_1016_j_bbmt_2014_10_015 crossref_primary_10_1016_j_jtct_2023_09_026 crossref_primary_10_1016_j_bbmt_2020_07_007 crossref_primary_10_1016_j_phrs_2020_105247 crossref_primary_10_1177_2040620718786437 crossref_primary_10_1038_bmt_2015_241 crossref_primary_10_1007_s12185_020_02926_6 crossref_primary_10_1016_j_bbmt_2014_02_021 crossref_primary_10_1016_j_bbmt_2019_12_771 crossref_primary_10_1016_j_bbmt_2016_05_019 crossref_primary_10_1038_s41409_018_0301_7 crossref_primary_10_1016_j_jtct_2023_09_010 crossref_primary_10_1038_s41409_017_0076_2 crossref_primary_10_1111_petr_13994 crossref_primary_10_1155_2017_3684812 crossref_primary_10_1007_s00520_017_3660_5 crossref_primary_10_1016_j_bbmt_2016_05_013 crossref_primary_10_1016_j_bbmt_2018_06_008 crossref_primary_10_1016_j_jgo_2019_09_012 crossref_primary_10_1038_s41408_022_00678_6 crossref_primary_10_1016_j_bbmt_2013_07_020 crossref_primary_10_1016_j_bbmt_2016_11_004 crossref_primary_10_3389_fonc_2018_00054 crossref_primary_10_1016_j_bbmt_2016_01_027 crossref_primary_10_1016_j_jtct_2021_08_020 crossref_primary_10_1001_jamanetworkopen_2024_33145 crossref_primary_10_1016_j_bbmt_2019_08_012 crossref_primary_10_1016_j_bbmt_2014_10_001 crossref_primary_10_1097_MOH_0000000000000220 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1200/JCO.2012.46.6193 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1527-7755 |
| ExternalDocumentID | 23715573 |
| Genre | Research Support, U.S. Gov't, Non-P.H.S Multicenter Study Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | Canada United States |
| GeographicLocations_xml | – name: Canada – name: United States |
| GrantInformation_xml | – fundername: NHLBI NIH HHS grantid: 5U01HL069294 – fundername: NCI NIH HHS grantid: U24-CA76518 – fundername: PHS HHS grantid: HHSH234200637015C |
| GroupedDBID | --- .55 0R~ 18M 2WC 34G 39C 4.4 53G 5GY 5RE 8F7 AARDX AAWTL AAYEP ABBLC ABJNI ABOCM ACGFO ACGFS ACGUR ADBBV AEGXH AENEX AIAGR ALMA_UNASSIGNED_HOLDINGS BAWUL C45 CGR CS3 CUY CVF DIK EBS ECM EIF EJD F5P F9R FBNNL FD8 GX1 H13 HZ~ IH2 KQ8 L7B LSO MJL N9A NPM O9- OK1 OVD OWW P2P QTD R1G RHI RLZ RUC SJN TEORI TR2 TWZ UDS VVN WH7 X7M YFH YQY 7X8 |
| ID | FETCH-LOGICAL-c524t-fa534ccf95b440e724329e96ed6845c06dc0491b51da77e281a61a776a8f83652 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 214 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000330520600024&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1527-7755 |
| IngestDate | Thu Oct 02 11:28:44 EDT 2025 Mon Jul 21 06:01:52 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 19 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c524t-fa534ccf95b440e724329e96ed6845c06dc0491b51da77e281a61a776a8f83652 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2012.46.6193?role=tab |
| PMID | 23715573 |
| PQID | 1373439701 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1373439701 pubmed_primary_23715573 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-07-01 |
| PublicationDateYYYYMMDD | 2013-07-01 |
| PublicationDate_xml | – month: 07 year: 2013 text: 2013-07-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of clinical oncology |
| PublicationTitleAlternate | J Clin Oncol |
| PublicationYear | 2013 |
| References | 14704658 - Bone Marrow Transplant. 2004 Jan;33(1):65-9 J Clin Oncol. 2013 Aug 10;31(23):2977 17459051 - Br J Haematol. 2007 Jun;137(5):461-7 18783584 - Transfus Med. 2008 Aug;18(4):250-9 21105791 - N Engl J Med. 2010 Nov 25;363(22):2091-101 16307018 - Leukemia. 2006 Feb;20(2):322-8 17038533 - Blood. 2007 Feb 15;109(4):1395-400 20800103 - Biol Blood Marrow Transplant. 2010 Nov;16(11):1541-8 21620989 - Biol Blood Marrow Transplant. 2011 Nov;17(11):1688-97 18721779 - Biol Blood Marrow Transplant. 2008 Sep;14(9 Suppl):37-44 18215785 - Biol Blood Marrow Transplant. 2008 Feb;14(2):246-55 10918426 - Bone Marrow Transplant. 2000 Jul;26(2):161-7 21345734 - Transfus Apher Sci. 2011 Apr;44(2):205-10 19528536 - Blood. 2009 Aug 13;114(7):1429-36 |
| References_xml | – reference: 19528536 - Blood. 2009 Aug 13;114(7):1429-36 – reference: 10918426 - Bone Marrow Transplant. 2000 Jul;26(2):161-7 – reference: 21620989 - Biol Blood Marrow Transplant. 2011 Nov;17(11):1688-97 – reference: 21105791 - N Engl J Med. 2010 Nov 25;363(22):2091-101 – reference: 21345734 - Transfus Apher Sci. 2011 Apr;44(2):205-10 – reference: 20800103 - Biol Blood Marrow Transplant. 2010 Nov;16(11):1541-8 – reference: 14704658 - Bone Marrow Transplant. 2004 Jan;33(1):65-9 – reference: 16307018 - Leukemia. 2006 Feb;20(2):322-8 – reference: - J Clin Oncol. 2013 Aug 10;31(23):2977 – reference: 18215785 - Biol Blood Marrow Transplant. 2008 Feb;14(2):246-55 – reference: 18783584 - Transfus Med. 2008 Aug;18(4):250-9 – reference: 18721779 - Biol Blood Marrow Transplant. 2008 Sep;14(9 Suppl):37-44 – reference: 17038533 - Blood. 2007 Feb 15;109(4):1395-400 – reference: 17459051 - Br J Haematol. 2007 Jun;137(5):461-7 |
| SSID | ssj0014835 |
| Score | 2.5355606 |
| Snippet | Over the past four decades, allogeneic hematopoietic cell transplantation (alloHCT) has evolved as a curative modality for patients with hematologic diseases.... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 2437 |
| SubjectTerms | Adolescent Adult Age Factors Aged Canada - epidemiology Child Child, Preschool Cohort Studies Female Hematologic Neoplasms - mortality Hematologic Neoplasms - surgery Hematopoietic Stem Cell Transplantation - utilization Hodgkin Disease - mortality Hodgkin Disease - surgery Humans Infant Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - surgery Lymphoma, Non-Hodgkin - mortality Lymphoma, Non-Hodgkin - surgery Male Middle Aged Myelodysplastic Syndromes - mortality Myelodysplastic Syndromes - surgery Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Precursor Cell Lymphoblastic Leukemia-Lymphoma - surgery Retrospective Studies SEER Program Survival Analysis Survival Rate Transplantation, Homologous United States - epidemiology Unrelated Donors |
| Title | Significant improvement in survival after allogeneic hematopoietic cell transplantation during a period of significantly increased use, older recipient age, and use of unrelated donors |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23715573 https://www.proquest.com/docview/1373439701 |
| Volume | 31 |
| WOSCitedRecordID | wos000330520600024&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1La9wwEBZtU0ovaZs-kvTBFEpO62Stl-VTKKGhlGa70BT2tsh6BEOQtvFuYP9Zfl41soNPhUIvxmAJGc14NJ7H9xHyqZHUa-NNobzRBa9NXTRe1kWpmZpayozSGWf2ezWbqcWing8Bt24oq7y3idlQ22gwRn5Ssorh4TktT1e_C2SNwuzqQKHxkOyw5MqgVleLMYvAVSbYRObW5EUKMaQpk2KcfDv7gXVd9JjLY5nTzn9zMPNBc_7sf1_xOdkdXEz43OvEC_LAhT3y5GJIou-Ro3kPV72dwOXYfdVN4AjmI5D19iW5-9leBSwlSrsPbY4-5GAitAG6TbIxSUshk4wDpu-TKrrWQEaBjavYYnskYGIA1hlB_Vr3bU4B-t5I0IAwy9FC9NCNS11v0wLozHbOwqZzE4hIJQ6Iw7HC9k1INnACOuSnOHkTcktOGm5jiDfdK_Lr_Mvl2ddiYHoojKB8XXgtGDfG16LhfOoqyhmtXS2dlYoLM5XWpD-ZshGl1VXlqCq1LNOd1MorJgV9TR6FGNw-ASdN2TRpqLCMOyWVY7oRViXRNNx4fUA-3gtvmb4k3AUdXNx0y1F8B-RNrwHLVQ_5saSsSo5XxQ7_YfZb8pRmzgys6X1HdnyyI-49eWxu12138yGraLrO5hd_AGHf9pc |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Significant+improvement+in+survival+after+allogeneic+hematopoietic+cell+transplantation+during+a+period+of+significantly+increased+use%2C+older+recipient+age%2C+and+use+of+unrelated+donors&rft.jtitle=Journal+of+clinical+oncology&rft.au=Hahn%2C+Theresa&rft.au=McCarthy%2C+Philip+L&rft.au=Hassebroek%2C+Anna&rft.au=Bredeson%2C+Christopher&rft.date=2013-07-01&rft.issn=1527-7755&rft.eissn=1527-7755&rft.volume=31&rft.issue=19&rft.spage=2437&rft_id=info:doi/10.1200%2FJCO.2012.46.6193&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1527-7755&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1527-7755&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1527-7755&client=summon |