Matrix remodeling stimulates stromal autophagy, "fueling" cancer cell mitochondrial metabolism and metastasis

We have previously demonstrated that loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts is a strong and independent predictor of poor clinical outcome in human breast cancer patients. However, the signaling mechanism(s) by which Cav-1 downregulation leads to this tumor-promoting mic...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 10; no. 12; pp. 2021 - 2034
Main Authors:	Castello-Cros, Remedios, Bonnuccelli, Gloria, Molchansky, Alex, Capozza, Franco, Witkiewicz, Agnieszka K., Birbe, Ruth, Howell, Anthony, Pestell, Richard G., Whitaker-Menezes, Diana, Sotgia, Federica, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 15.06.2011 Landes Bioscience
Subjects:	Animals Autophagy Binding Biology Bioscience Breast Neoplasms - pathology Calcium Cancer Caveolin 1 - metabolism Cell Cell Line, Tumor Coculture Techniques Cycle Extracellular Matrix - metabolism Fibroblasts - pathology Humans Landes Mice Mitochondria - metabolism Mitochondria - pathology Neoplasm Metastasis Neoplasms - pathology Neoplasms - ultrastructure Organogenesis Plasminogen Activator Inhibitor 1 - metabolism Plasminogen Activator Inhibitor 2 - metabolism Proteins Stromal Cells - pathology Transplantation, Heterologous Tumor Microenvironment
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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