Medroxyprogesterone acetate positively modulates specific GABAA-receptor subtypes - affecting memory and cognition

Medroxyprogesterone acetate (MPA) is a progestin widely used in humans as hormone replacement therapy and at other indications. Many progestin metabolites, as the progesterone metabolite allopregnanolone, have GABAA-receptor modulatory effects and are known to affect memory, learning, appetite, and...

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Bibliographic Details

Published in:	Psychoneuroendocrinology Vol. 141; p. 105754
Main Authors:	Das, Roshni, Ragagnin, Gianna, Sjöstedt, Jessica, Johansson, Maja, Haage, David, Druzin, Michael, Johansson, Staffan, Bäckström, Torbjörn
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01.07.2022
Subjects:	Alpha5 GABA-A receptor Dementia GABA-A receptor Medroxyprogesterone-acetate Neurosteroids Positive GABA-AR modulator Medroxyprogesterone-acetate Positive GABA-AR modulator Alpha5 GABA-A receptor Neurosteroids GABA-A receptor Dementia
ISSN:	0306-4530, 1873-3360, 1873-3360
Online Access:	Get full text
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