Long-Term Colorectal-Cancer Mortality after Adenoma Removal

This analysis of Norwegian registry data suggests that colonoscopic surveillance during the 8 years after removal of low-risk adenomas is not required for a reduction in colorectal-cancer mortality. Screening programs for colorectal cancer are currently implemented in many Western populations 1 , 2...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 371; no. 9; pp. 799 - 807
Main Authors: Løberg, Magnus, Kalager, Mette, Holme, Øyvind, Hoff, Geir, Adami, Hans-Olov, Bretthauer, Michael
Format: Journal Article
Language:English
Published: Waltham, MA Massachusetts Medical Society 28.08.2014
Subjects:
Adenoma
Adenoma - mortality
Adenoma - surgery
Adult
Age
Aged
Aged, 80 and over
Biological and medical sciences
Colon
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - mortality
Colorectal Neoplasms - prevention & control
Colorectal Neoplasms - surgery
Dysplasia
Female
Follow-Up Studies
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Male
Medical sciences
Middle Aged
Mortality
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Multivariate Analysis
Norway - epidemiology
Preventive medicine
Registries
Risk
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumors
Norway
United States > US
Rectal disease
Prognosis
Mortality
Colorectal cancer
Malignant tumor
Long term
Colonic disease
Medicine
Colorectal adenoma
Digestive diseases
Intestinal disease
Benign neoplasm
Cancer
ISSN:0028-4793, 1533-4406, 1533-4406
Online Access:Get full text
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Summary:This analysis of Norwegian registry data suggests that colonoscopic surveillance during the 8 years after removal of low-risk adenomas is not required for a reduction in colorectal-cancer mortality. Screening programs for colorectal cancer are currently implemented in many Western populations 1 , 2 because randomized trials have documented an association between screening and a sustained reduction in colorectal-cancer mortality. 3 The benefit is most likely due to early detection of cancer, endoscopic removal of adenomas, and surveillance of patients who are considered to be at high risk for the development of new neoplastic lesions. 4 , 5 However, precise quantification of the risk of death from cancer after adenoma removal has been hampered by the scarceness of large, population-based studies with long follow-up periods. Previous studies were performed in populations undergoing intensive surveillance, . . .
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ISSN:0028-4793
1533-4406
1533-4406
DOI:10.1056/NEJMoa1315870