Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

Increased matrix rigidity associated with the fibrotic reaction is documented to stimulate intracellular signalling pathways that promote cancer cell survival and tumour growth. Pancreatic cancer is one of the stiffest of all human solid carcinomas and is characterised by a remarkable desmoplastic r...

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Bibliographic Details
Published in:	Oncogenesis (New York, NY) Vol. 6; no. 7; p. e352
Main Authors:	Rice, A J, Cortes, E, Lachowski, D, Cheung, B C H, Karim, S A, Morton, J P, del Río Hernández, A
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03.07.2017 Nature Publishing Group
Subjects:	13/106 14 14/1 14/3 14/63 631/67/327 631/80/83 631/80/86 96/10 Animal models Apoptosis Carcinoma Cell Biology Cell size Cell survival Chemoresistance Chemotherapy Drug resistance E-cadherin Extracellular matrix Gemcitabine Genetic engineering Human Genetics Internal Medicine Intracellular signalling Medicine Medicine & Public Health Mesenchyme Oncology Original original-article Paclitaxel Pancreatic cancer Rodents Signal transduction Survival Tumor cell lines Tumors Vimentin Yes-associated protein β-catenin
ISSN:	2157-9024, 2157-9024
Online Access:	Get full text
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