Interleukin-21 receptor-mediated signals control autoreactive T cell infiltration in pancreatic islets

It remains unclear how interleukin-21 receptor (IL-21R) contributes to type 1 diabetes. Here we have shown that dendritic cells (DCs) in the pancreas required IL-21R not for antigen uptake, but to acquire the chemokine receptor CCR7 and migrate into the draining lymph node. Consequently, less antige...

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Bibliographic Details
Published in:	Immunity (Cambridge, Mass.) Vol. 36; no. 6; p. 1060
Main Authors:	Van Belle, Tom L, Nierkens, Stefan, Arens, Ramon, von Herrath, Matthias G
Format:	Journal Article
Language:	English
Published:	United States 29.06.2012
Subjects:	Adoptive Transfer Animals Antigen Presentation Autoimmunity - immunology CD4-Positive T-Lymphocytes - immunology CD40 Antigens - immunology CD40 Ligand - immunology CD8-Positive T-Lymphocytes - immunology Chemotaxis, Leukocyte Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Disease Models, Animal Disease Resistance Interleukin-21 Receptor alpha Subunit - deficiency Interleukin-21 Receptor alpha Subunit - genetics Interleukin-21 Receptor alpha Subunit - physiology Islets of Langerhans - immunology Lymph Nodes - immunology Lymph Nodes - pathology Lymphocyte Activation Lymphocyte Cooperation Lymphocytic choriomeningitis virus Mice Mice, Inbred NOD Receptors, CCR7 - metabolism Specific Pathogen-Free Organisms Spleen - immunology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - transplantation
ISSN:	1097-4180, 1097-4180
Online Access:	Get more information
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