Neurogenesis and progenitor cell distribution in the subgranular zone and subventricular zone of the adult sheep brain

•We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The sheep subventricular zone has far more progenitors than the hippocampus.•The overall structure of the sheep subventricular zone is similar to hu...

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Vydáno v:	Neuroscience Ročník 244; s. 173 - 187
Hlavní autoři:	Low, V.F., Faull, R.L.M., Bennet, L., Gunn, A.J., Curtis, M.A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Amsterdam Elsevier Ltd 06.08.2013 Elsevier
Témata:	Age Factors animal model Animals Biological and medical sciences Brain - cytology Brain - growth & development brain plasticity Cell Proliferation Female Fundamental and applied biological sciences. Psychology germinal niche Neurogenesis Neurology Sheep Stem Cells - cytology Stem Cells - physiology transgenic sheep Vertebrates: nervous system and sense organs PBS DG PCNA DAB TBS transgenic sheep EL SGZ CN GFAP GCL TBS-T germinal niche NeuN SVZ neurogenesis RMS HD animal model BrdU brain plasticity caudate nucleus neuronal nuclear antigen 5-bromo-2′-deoxyuridine phosphate-buffered saline tris-buffered saline with Triton X-100 Huntington’s disease rostral migratory stream subventricular zone 3,3-diaminobenzidine granule cell layer subgranular zone proliferating cell nuclear antigen dentate gyrus tris-buffered saline ependymal layer glial fibrillary acidic protein Animal model Central nervous system Precursor cell Transgenic animal Neurogenesis Encephalon Vertebrata Mammalia Distribution Plasticity Sheep Artiodactyla Ungulata Progenitor cell
ISSN:	0306-4522, 1873-7544, 1873-7544
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Abstract	•We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The sheep subventricular zone has far more progenitors than the hippocampus.•The overall structure of the sheep subventricular zone is similar to humans. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2′-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents.
AbstractList	Highlights • We studied adult sheep neurogenic niches after administering BrdU. • Progenitor cell distribution in the sheep subventricular zone is similar to humans. • The sheep subventricular zone has far more progenitors than the hippocampus. • The overall structure of the sheep subventricular zone is similar to humans. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2'-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2'-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents.Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2'-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents. •We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The sheep subventricular zone has far more progenitors than the hippocampus.•The overall structure of the sheep subventricular zone is similar to humans. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2′-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents.
Author	Low, V.F. Gunn, A.J. Faull, R.L.M. Bennet, L. Curtis, M.A.
Author_xml	– sequence: 1 givenname: V.F. surname: Low fullname: Low, V.F. organization: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 2 givenname: R.L.M. surname: Faull fullname: Faull, R.L.M. organization: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 3 givenname: L. surname: Bennet fullname: Bennet, L. organization: Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 4 givenname: A.J. surname: Gunn fullname: Gunn, A.J. organization: Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 5 givenname: M.A. surname: Curtis fullname: Curtis, M.A. email: m.curtis@auckland.ac.nz organization: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
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Keywords	PBS DG PCNA DAB TBS transgenic sheep EL SGZ CN GFAP GCL TBS-T germinal niche NeuN SVZ neurogenesis RMS HD animal model BrdU brain plasticity caudate nucleus neuronal nuclear antigen 5-bromo-2′-deoxyuridine phosphate-buffered saline tris-buffered saline with Triton X-100 Huntington’s disease rostral migratory stream subventricular zone 3,3-diaminobenzidine granule cell layer subgranular zone proliferating cell nuclear antigen dentate gyrus tris-buffered saline ependymal layer glial fibrillary acidic protein Animal model Central nervous system Precursor cell Transgenic animal Neurogenesis Encephalon Vertebrata Mammalia Distribution Plasticity Sheep Artiodactyla Ungulata Progenitor cell
Language	English
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Snippet	•We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The... Highlights • We studied adult sheep neurogenic niches after administering BrdU. • Progenitor cell distribution in the sheep subventricular zone is similar to... Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and...
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SubjectTerms	Age Factors animal model Animals Biological and medical sciences Brain - cytology Brain - growth & development brain plasticity Cell Proliferation Female Fundamental and applied biological sciences. Psychology germinal niche Neurogenesis Neurology Sheep Stem Cells - cytology Stem Cells - physiology transgenic sheep Vertebrates: nervous system and sense organs
Title	Neurogenesis and progenitor cell distribution in the subgranular zone and subventricular zone of the adult sheep brain
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