Neurogenesis and progenitor cell distribution in the subgranular zone and subventricular zone of the adult sheep brain

•We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The sheep subventricular zone has far more progenitors than the hippocampus.•The overall structure of the sheep subventricular zone is similar to hu...

Celý popis

Uložené v:

Podrobná bibliografia
Vydané v:	Neuroscience Ročník 244; s. 173 - 187
Hlavní autori:	Low, V.F., Faull, R.L.M., Bennet, L., Gunn, A.J., Curtis, M.A.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	Amsterdam Elsevier Ltd 06.08.2013 Elsevier
Predmet:	Age Factors animal model Animals Biological and medical sciences Brain - cytology Brain - growth & development brain plasticity Cell Proliferation Female Fundamental and applied biological sciences. Psychology germinal niche Neurogenesis Neurology Sheep Stem Cells - cytology Stem Cells - physiology transgenic sheep Vertebrates: nervous system and sense organs PBS DG PCNA DAB TBS transgenic sheep EL SGZ CN GFAP GCL TBS-T germinal niche NeuN SVZ neurogenesis RMS HD animal model BrdU brain plasticity caudate nucleus neuronal nuclear antigen 5-bromo-2′-deoxyuridine phosphate-buffered saline tris-buffered saline with Triton X-100 Huntington’s disease rostral migratory stream subventricular zone 3,3-diaminobenzidine granule cell layer subgranular zone proliferating cell nuclear antigen dentate gyrus tris-buffered saline ependymal layer glial fibrillary acidic protein Animal model Central nervous system Precursor cell Transgenic animal Neurogenesis Encephalon Vertebrata Mammalia Distribution Plasticity Sheep Artiodactyla Ungulata Progenitor cell
ISSN:	0306-4522, 1873-7544, 1873-7544
On-line prístup:	Získať plný text
Tagy:	Pridať tag Žiadne tagy, Buďte prvý, kto otaguje tento záznam!

Abstract	•We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The sheep subventricular zone has far more progenitors than the hippocampus.•The overall structure of the sheep subventricular zone is similar to humans. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2′-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents.
AbstractList	Highlights • We studied adult sheep neurogenic niches after administering BrdU. • Progenitor cell distribution in the sheep subventricular zone is similar to humans. • The sheep subventricular zone has far more progenitors than the hippocampus. • The overall structure of the sheep subventricular zone is similar to humans. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2'-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2'-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents.Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2'-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents. •We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The sheep subventricular zone has far more progenitors than the hippocampus.•The overall structure of the sheep subventricular zone is similar to humans. Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and distribution of proliferation are surprisingly heterogeneous between species. In rodents, proliferation is high in both the SVZ and SGZ, while in humans proliferation is prominent in the SVZ but limited in the SGZ. To accurately study proliferation and how it changes in human disease, we should focus on animals in which the patterns of proliferation are consistent with the human brain. In this study, we characterized the neurogenic niches of the adult sheep, an animal model with a longer lifespan than rodents and a highly gyrencephalic brain, using 5-bromo-2′-deoxyuridine (BrdU) as a mitotic marker and neuronal nuclear antigen to identify neuronal lineage cells. Our study demonstrates that the sheep SVZ is organized into the same distinct layers that are comparable to what has been described in humans. The rate of maturation of new neurons was slower in sheep than in previous reports in rodents, with only 20% of BrdU-positive cells showing neuronal phenotype after 4 months survival following BrdU administration. Most importantly, as in the human, there was much greater proliferation in the sheep SVZ than in the SGZ. These results suggest that the sheep is a better basis for comparisons with human SVZ and SGZ neurogenesis than rodents.
Author	Low, V.F. Gunn, A.J. Faull, R.L.M. Bennet, L. Curtis, M.A.
Author_xml	– sequence: 1 givenname: V.F. surname: Low fullname: Low, V.F. organization: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 2 givenname: R.L.M. surname: Faull fullname: Faull, R.L.M. organization: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 3 givenname: L. surname: Bennet fullname: Bennet, L. organization: Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 4 givenname: A.J. surname: Gunn fullname: Gunn, A.J. organization: Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand – sequence: 5 givenname: M.A. surname: Curtis fullname: Curtis, M.A. email: m.curtis@auckland.ac.nz organization: Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27450042$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/23587842$$D View this record in MEDLINE/PubMed
BookMark	eNqNkl1rFDEUhoNU7Lb6F2QQBG9mPPmaZL0QtX5C0Qv1OmQzZ9qss5k1mVmov97M7JZKQdjchBye8ybnfXNGTkIfkJBnFCoKtH65rgKOsU_OY3BYMaC8AlEB1A_IgmrFSyWFOCEL4FCXQjJ2Ss5SWkNeUvBH5JRxqZUWbEF2XyepKwyYfCpsaIrtfPRDHwuHXVc0Pg3Rr8bB96HwoRiusUjj6iraMHY2Fn_y4-bGXNxhyKy7q_ftzNtm7IYiXSNui1W0PjwmD1vbJXxy2M_Jz48fflx8Li-_ffpy8faydJKJodSMyqZuuNLIwSrJW4C21ktqNTCnWr7SitWU8SVvec2EY0zTWjXScQ5Ut_ycvNjr5ql-j5gGs_FpGssG7MdkKJdKLOulkBl9ekDH1QYbs41-Y-ONufUqA88PgE3Odm02wPl0xykhAWbuzZ5zOaMUsTXOD3ayb8ijd4aCmWI0a_NvjGaK0YAwOcYs8eqexO0tRzW_3zdjNnbnMZoD1fiIbjBN74-TeX1PxnU--Dz5L7zBtO7HGHJ0hprEDJjv02eb_hrlAJzNPrz7v8Cxr_gLKGXsYw
CODEN	NRSCDN
CitedBy_id	crossref_primary_10_1002_cne_70070 crossref_primary_10_1002_cne_24365 crossref_primary_10_1016_j_jchemneu_2019_01_007 crossref_primary_10_3389_fnins_2016_00332 crossref_primary_10_3389_fvets_2022_961413 crossref_primary_10_3758_s13415_025_01332_x crossref_primary_10_3389_fnins_2024_1493605 crossref_primary_10_3390_biology11091251 crossref_primary_10_1111_nan_12337 crossref_primary_10_1177_03009858231182337 crossref_primary_10_1016_j_neulet_2020_135616 crossref_primary_10_1007_s11515_016_1407_1 crossref_primary_10_1016_j_rvsc_2023_105025 crossref_primary_10_3389_fnins_2017_00570 crossref_primary_10_1038_s41598_018_20793_4 crossref_primary_10_1111_1749_4877_12335 crossref_primary_10_1016_j_crad_2016_01_017 crossref_primary_10_3390_cells11172735 crossref_primary_10_1007_s11259_014_9614_1 crossref_primary_10_2527_jas2017_1710
Cites_doi	10.1073/pnas.1532244100 10.1038/3305 10.1038/6365 10.1111/j.1474-9726.2006.00243.x 10.1038/cr.2011.83 10.1095/biolreprod.108.075341 10.1038/491031a 10.1016/S0092-8674(00)80783-7 10.1016/j.neuroscience.2010.08.022 10.1093/hmg/ddq063 10.1073/pnas.1017099108 10.1046/j.1460-9568.2002.02263.x 10.1016/j.devbrainres.2004.03.021 10.1016/j.neuroscience.2004.12.051 10.1016/j.nbd.2010.09.012 10.1016/j.neuropharm.2010.01.012 10.1016/j.neuroscience.2011.09.010 10.1073/pnas.96.10.5768 10.1038/444532a 10.1002/cne.22026 10.1016/j.nbd.2005.05.006 10.1002/dneu.22028 10.1097/00005072-198511000-00003 10.1097/00001756-200404090-00014 10.1038/sj.npp.1300234 10.1038/npp.2009.75 10.1016/j.tvjl.2007.01.023 10.1038/nn.2553 10.1073/pnas.96.9.5263 10.1038/nrn2216 10.1016/S0197-4580(03)00083-6 10.1523/JNEUROSCI.17-13-05046.1997 10.1073/pnas.2634794100 10.1371/journal.pone.0036016 10.1126/science.1136281 10.1073/pnas.081011098 10.1067/mcp.2001.115446 10.1038/nm0598-555 10.1126/science.271.5251.978 10.1016/j.drudis.2007.07.005 10.1038/sj.mp.4001791 10.1038/386493a0 10.1073/pnas.081074998 10.1111/j.1460-9568.2006.04715.x 10.1073/pnas.0912810107 10.1016/j.yhbeh.2010.07.006
ContentType	Journal Article
Copyright	2013 IBRO IBRO 2014 INIST-CNRS Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
Copyright_xml	– notice: 2013 IBRO – notice: IBRO – notice: 2014 INIST-CNRS – notice: Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
DBID	AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7X8
DOI	10.1016/j.neuroscience.2013.04.006
DatabaseName	CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic
DatabaseTitle	CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic
DatabaseTitleList	MEDLINE MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Anatomy & Physiology
EISSN	1873-7544
EndPage	187
ExternalDocumentID	23587842 27450042 10_1016_j_neuroscience_2013_04_006 S0306452213003242 1_s2_0_S0306452213003242
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --M -DZ -~X .1- .FO .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 4.4 457 4G. 5RE 5VS 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AATTM AAXKI AAXLA AAXUO AAYWO ABCQJ ABFNM ABFRF ABJNI ABLJU ABMAC ABTEW ABWVN ABXDB ACDAQ ACGFO ACGFS ACIUM ACLOT ACRLP ACVFH ADBBV ADCNI ADEZE AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFPUW AFRHN AFTJW AFXIZ AGUBO AGWIK AGYEJ AHHHB AIEXJ AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA HMQ IHE J1W KOM L7B M2V M41 MO0 MOBAO N9A O-L O9- OAUVE OP~ OZT P-8 P-9 P2P PC. Q38 ROL RPZ SCC SDF SDG SDP SES SPCBC SSN SSZ T5K UNMZH Z5R ~G- ~HD .55 .GJ 29N 53G AACTN AAQXK ACRPL ADMUD ADNMO AFCTW AFJKZ AFKWA AGHFR AJOXV AMFUW ASPBG AVWKF AZFZN FEDTE FGOYB G-2 HVGLF HZ~ R2- RIG SEW SNS WUQ X7M YYP ZGI ZXP AADPK AAIAV ABYKQ AJBFU 9DU AAYXX AGQPQ AIGII APXCP CITATION BNPGV IQODW SSH CGR CUY CVF ECM EIF NPM 7X8
ID	FETCH-LOGICAL-c524t-8215d6d378e30a753f00f6891a802c7f3b872612393f3624c228167d5c33018f3
ISICitedReferencesCount	23
ISICitedReferencesURI	http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000320347800015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN	0306-4522 1873-7544
IngestDate	Sat Sep 27 20:44:13 EDT 2025 Thu Apr 03 06:52:58 EDT 2025 Wed Apr 02 07:25:18 EDT 2025 Sat Nov 29 03:40:33 EST 2025 Tue Nov 18 22:00:31 EST 2025 Fri Feb 23 02:26:43 EST 2024 Sun Feb 23 10:18:48 EST 2025 Tue Oct 14 19:30:27 EDT 2025
IsPeerReviewed	true
IsScholarly	true
Keywords	PBS DG PCNA DAB TBS transgenic sheep EL SGZ CN GFAP GCL TBS-T germinal niche NeuN SVZ neurogenesis RMS HD animal model BrdU brain plasticity caudate nucleus neuronal nuclear antigen 5-bromo-2′-deoxyuridine phosphate-buffered saline tris-buffered saline with Triton X-100 Huntington’s disease rostral migratory stream subventricular zone 3,3-diaminobenzidine granule cell layer subgranular zone proliferating cell nuclear antigen dentate gyrus tris-buffered saline ependymal layer glial fibrillary acidic protein Animal model Central nervous system Precursor cell Transgenic animal Neurogenesis Encephalon Vertebrata Mammalia Distribution Plasticity Sheep Artiodactyla Ungulata Progenitor cell
Language	English
License	https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
LinkModel	OpenURL
MergedId	FETCHMERGED-LOGICAL-c524t-8215d6d378e30a753f00f6891a802c7f3b872612393f3624c228167d5c33018f3
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
PMID	23587842
PQID	1357496945
PQPubID	23479
PageCount	15
ParticipantIDs	proquest_miscellaneous_1357496945 pubmed_primary_23587842 pascalfrancis_primary_27450042 crossref_citationtrail_10_1016_j_neuroscience_2013_04_006 crossref_primary_10_1016_j_neuroscience_2013_04_006 elsevier_sciencedirect_doi_10_1016_j_neuroscience_2013_04_006 elsevier_clinicalkeyesjournals_1_s2_0_S0306452213003242 elsevier_clinicalkey_doi_10_1016_j_neuroscience_2013_04_006
PublicationCentury	2000
PublicationDate	2013-08-06
PublicationDateYYYYMMDD	2013-08-06
PublicationDate_xml	– month: 08 year: 2013 text: 2013-08-06 day: 06
PublicationDecade	2010
PublicationPlace	Amsterdam
PublicationPlace_xml	– name: Amsterdam – name: United States
PublicationTitle	Neuroscience
PublicationTitleAlternate	Neuroscience
PublicationYear	2013
Publisher	Elsevier Ltd Elsevier
Publisher_xml	– name: Elsevier Ltd – name: Elsevier
References	Malberg, Duman (b0190) 2003; 28 Eriksson, Perfilieva, Bjork-Eriksson, Alborn, Nordborg, Peterson, Gage (b0085) 1998; 4 Curtis, Faull, Eriksson (b0055) 2007; 8 Kempermann, Kuhn, Gage (b0145) 1997; 386 Wang, Liu, Liu, Zhao, You, Wang, Zhang, Wei, Ma, Zhang, Zhang, Chen, Song, Yang (b0255) 2011; 21 Doetsch, García-Verdugo, Alvarez-Buylla (b0075) 1997; 17 Curtis, Penney, Pearson, van Roon-Mom, Butterworth, Dragunow, Connor, Faull (b0045) 2003; 100 Bondolfi, Ermini, Long, Ingram, Jucker (b0025) 2004; 25 Reif, Fritzen, Finger, Strobel, Lauer, Schmitt, Lesch (b0210) 2006; 11 Simpson, Gil-Mohapel, Pouladi, Ghilan, Xie, Hayden, Christie (b0220) 2011; 41 Bedard, Levesque, Bernier, Parent (b0010) 2002; 16 Jin, Peel, Mao, Xie, Cottrell, Henshall, Greenberg (b0135) 2004; 101 Curtis, Low, Faull (b0065) 2012; 72 Lazic, Grote, Blakemore, Hannan, Van Dellen, Phillips, Barker (b0170) 2006; 23 Lois, García-Verdugo, Alvarez-Buylla (b0175) 1996; 271 Jin, Minami, Lan, Mao, Batteur, Simon, Greenberg (b0130) 2001; 98 Brus, Meurisse, Gheusi, Keller, Lledo, Lévy (b0040) 2012 Hawken, Jorre, Rodger, Esmaili, Blache, Martin (b0120) 2009; 80 Malik, Lewis, Isaacs, Haskins, Van Winkle, Vite, Watson (b0195) 2012; 7 Fietz, Kelava, Vogt, Wilsch-Bräuninger, Stenzel, Fish, Corbeil, Riehn, Distler, Nitsch, Huttner (b0245) 2010; 13 Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Academic Press. Jacobsen, Bawden, Rudiger, McLaughlan, Reid, Waldvogel, MacDonald, Gusella, Walker, Kelly, Webb, Faull, Rees, Snell (b0125) 2010; 19 Boldrini, Underwood, Hen, Rosoklija, Dwork, Mann, Arango (b0015) 2009; 34 Gould, Beylin, Tanapat, Reeves, Shors (b0110) 1999; 2 Kempermann, Gage (b0140) 1998; 4 Pearson (b0200) 2006; 444 Rao, Hattiangady, Shetty (b0205) 2006; 5 Bedard, Parent (b0005) 2004; 151 Fedele, Roybon, Nordström, Li, Brundin (b0240) 2011; 173 Dimasi (b0070) 2001; 69 Doetsch, Caillé, Lim, García-Verdugo, Alvarez-Buylla (b0080) 1999; 97 Taffe, Kotzebue, Crean, Crawford, Edwards, Mandyam (b0225) 2010; 107 Curtis, Penney, Pearson, Dragunow, Connor, Faull (b0050) 2005; 132 Gil-Perotin, Duran-Moreno, Belzunegui, Luquin, Garcia-Verdugo (b0105) 2009; 514 Kornack, Rakic (b0160) 2001; 98 Kohler, Williams, Stanton, Cameron, Greenough (b0150) 2011; 108 Curtis, Kam, Nannmark, Anderson, Axell, Wikkelso, Holtas, van Roon-Mom, Bjork-Eriksson, Nordborg, Frisen, Dragunow, Faull, Eriksson (b0060) 2007; 315 Sartipy, Björquist, Strehl, Hyllner (b0215) 2007; 12 Vonsattel, Myers, Stevens, Ferrante, Bird, Richardson (b0230) 1985; 44 Gould, Reeves, Fallah, Tanapat, Gross, Fuchs (b0115) 1999; 96 Lazic, Grote, Armstrong, Blakemore, Hannan, van Dellen, Barker (b0165) 2004; 15 Bonfanti, Ponti (b0030) 2008; 175 Brus, Meurisse, Franceschini, Keller, Lévy (b0035) 2010; 58 Gil, Mohapel, Araújo, Popovic, Li, Brundin, Petersén (b0100) 2005; 20 Low, Dragunow, Tippett, Faull, Curtis (b0180) 2011; 199 Lucassen, Stumpel, Wang, Aronica (b0185) 2010; 58 Bolker (b0020) 2012; 491 Kornack, Rakic (b0155) 1999; 96 Taffe (10.1016/j.neuroscience.2013.04.006_b0225) 2010; 107 Kornack (10.1016/j.neuroscience.2013.04.006_b0155) 1999; 96 Lazic (10.1016/j.neuroscience.2013.04.006_b0170) 2006; 23 Rao (10.1016/j.neuroscience.2013.04.006_b0205) 2006; 5 Reif (10.1016/j.neuroscience.2013.04.006_b0210) 2006; 11 Curtis (10.1016/j.neuroscience.2013.04.006_b0060) 2007; 315 Eriksson (10.1016/j.neuroscience.2013.04.006_b0085) 1998; 4 Vonsattel (10.1016/j.neuroscience.2013.04.006_b0230) 1985; 44 Brus (10.1016/j.neuroscience.2013.04.006_b0040) 2012 10.1016/j.neuroscience.2013.04.006_b0250 Bedard (10.1016/j.neuroscience.2013.04.006_b0010) 2002; 16 Boldrini (10.1016/j.neuroscience.2013.04.006_b0015) 2009; 34 Pearson (10.1016/j.neuroscience.2013.04.006_b0200) 2006; 444 Gould (10.1016/j.neuroscience.2013.04.006_b0115) 1999; 96 Dimasi (10.1016/j.neuroscience.2013.04.006_b0070) 2001; 69 Bondolfi (10.1016/j.neuroscience.2013.04.006_b0025) 2004; 25 Doetsch (10.1016/j.neuroscience.2013.04.006_b0075) 1997; 17 Bonfanti (10.1016/j.neuroscience.2013.04.006_b0030) 2008; 175 Curtis (10.1016/j.neuroscience.2013.04.006_b0055) 2007; 8 Sartipy (10.1016/j.neuroscience.2013.04.006_b0215) 2007; 12 Kempermann (10.1016/j.neuroscience.2013.04.006_b0140) 1998; 4 Kohler (10.1016/j.neuroscience.2013.04.006_b0150) 2011; 108 Hawken (10.1016/j.neuroscience.2013.04.006_b0120) 2009; 80 Malik (10.1016/j.neuroscience.2013.04.006_b0195) 2012; 7 Curtis (10.1016/j.neuroscience.2013.04.006_b0045) 2003; 100 Lazic (10.1016/j.neuroscience.2013.04.006_b0165) 2004; 15 Lois (10.1016/j.neuroscience.2013.04.006_b0175) 1996; 271 Gil (10.1016/j.neuroscience.2013.04.006_b0100) 2005; 20 Kornack (10.1016/j.neuroscience.2013.04.006_b0160) 2001; 98 Lucassen (10.1016/j.neuroscience.2013.04.006_b0185) 2010; 58 Fedele (10.1016/j.neuroscience.2013.04.006_b0240) 2011; 173 Fietz (10.1016/j.neuroscience.2013.04.006_b0245) 2010; 13 Bedard (10.1016/j.neuroscience.2013.04.006_b0005) 2004; 151 Gould (10.1016/j.neuroscience.2013.04.006_b0110) 1999; 2 Bolker (10.1016/j.neuroscience.2013.04.006_b0020) 2012; 491 Malberg (10.1016/j.neuroscience.2013.04.006_b0190) 2003; 28 Curtis (10.1016/j.neuroscience.2013.04.006_b0050) 2005; 132 Kempermann (10.1016/j.neuroscience.2013.04.006_b0145) 1997; 386 Simpson (10.1016/j.neuroscience.2013.04.006_b0220) 2011; 41 Doetsch (10.1016/j.neuroscience.2013.04.006_b0080) 1999; 97 Curtis (10.1016/j.neuroscience.2013.04.006_b0065) 2012; 72 Jin (10.1016/j.neuroscience.2013.04.006_b0135) 2004; 101 Low (10.1016/j.neuroscience.2013.04.006_b0180) 2011; 199 Jacobsen (10.1016/j.neuroscience.2013.04.006_b0125) 2010; 19 Wang (10.1016/j.neuroscience.2013.04.006_b0255) 2011; 21 Brus (10.1016/j.neuroscience.2013.04.006_b0035) 2010; 58 Gil-Perotin (10.1016/j.neuroscience.2013.04.006_b0105) 2009; 514 Jin (10.1016/j.neuroscience.2013.04.006_b0130) 2001; 98
References_xml	– volume: 15 start-page: 811 year: 2004 ident: b0165 article-title: Decreased hippocampal cell proliferation in R6/1 Huntington’s mice publication-title: Neuroreport – volume: 98 start-page: 4752 year: 2001 end-page: 4757 ident: b0160 article-title: The generation, migration, and differentiation of olfactory neurons in the adult primate brain publication-title: Proc Natl Acad Sci U S A – volume: 7 start-page: e36016 year: 2012 ident: b0195 article-title: Identification of the rostral migratory stream in the canine and feline brain publication-title: PLoS One – volume: 101 start-page: 343 year: 2004 ident: b0135 article-title: Increased hippocampal neurogenesis in Alzheimer’s disease publication-title: Proc Natl Acad Sci U S A – volume: 386 start-page: 493 year: 1997 end-page: 495 ident: b0145 article-title: More hippocampal neurons in adult mice living in an enriched environment publication-title: Nature – volume: 58 start-page: 737 year: 2010 end-page: 746 ident: b0035 article-title: Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young publication-title: Horm Behav – volume: 69 start-page: 297 year: 2001 end-page: 307 ident: b0070 article-title: Risks in new drug development: approval success rates for investigational drugs publication-title: Clin Pharmacol Ther – volume: 514 start-page: 533 year: 2009 end-page: 554 ident: b0105 article-title: Ultrastructure of the subventricular zone in publication-title: J Comp Neurol – volume: 96 start-page: 5768 year: 1999 end-page: 5773 ident: b0155 article-title: Continuation of neurogenesis in the hippocampus of the adult macaque monkey publication-title: Proc Natl Acad Sci U S A – volume: 271 start-page: 978 year: 1996 end-page: 981 ident: b0175 article-title: Chain migration of neuronal precursors publication-title: Science – volume: 132 start-page: 777 year: 2005 end-page: 788 ident: b0050 article-title: The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington’s disease human brain publication-title: Neuroscience – volume: 17 start-page: 5046 year: 1997 end-page: 5061 ident: b0075 article-title: Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain publication-title: J Neurosci – volume: 16 start-page: 1917 year: 2002 end-page: 1924 ident: b0010 article-title: The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl-2 publication-title: Eur J Neurosci – volume: 315 start-page: 1243 year: 2007 end-page: 1249 ident: b0060 article-title: Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension publication-title: Science – volume: 491 start-page: 31 year: 2012 end-page: 33 ident: b0020 article-title: There’s more to life than rats and flies publication-title: Nature – volume: 41 start-page: 249 year: 2011 end-page: 260 ident: b0220 article-title: Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease publication-title: Neurobiol Dis – volume: 34 start-page: 2376 year: 2009 end-page: 2389 ident: b0015 article-title: Antidepressants increase neural progenitor cells in the human hippocampus publication-title: Neuropsychopharmacology – volume: 98 start-page: 4710 year: 2001 ident: b0130 article-title: Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat publication-title: Proc Natl Acad Sci U S A – volume: 199 start-page: 577 year: 2011 end-page: 588 ident: b0180 article-title: No change in progenitor cell proliferation in the hippocampus in Huntington’s disease publication-title: Neuroscience – volume: 28 start-page: 1562 year: 2003 end-page: 1571 ident: b0190 article-title: Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment publication-title: Neuropsychopharmacology – volume: 173 start-page: 76 year: 2011 end-page: 81 ident: b0240 article-title: Neurogenesis in the R6/2 mouse model of Huntington’s disease is impaired at the level of NeuroD1 publication-title: Neuroscience – volume: 151 start-page: 159 year: 2004 end-page: 168 ident: b0005 article-title: Evidence of newly generated neurons in the human olfactory bulb publication-title: Dev Brain Res – volume: 175 start-page: 310 year: 2008 end-page: 331 ident: b0030 article-title: Adult mammalian neurogenesis and the New Zealand white rabbit publication-title: Vet J – volume: 2 start-page: 260 year: 1999 end-page: 265 ident: b0110 article-title: Learning enhances adult neurogenesis in the hippocampal formation publication-title: Nat Neurosci – volume: 21 start-page: 1534 year: 2011 end-page: 1550 ident: b0255 article-title: Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain publication-title: Cell Res – volume: 97 start-page: 703 year: 1999 end-page: 716 ident: b0080 article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain publication-title: Cell – volume: 19 start-page: 1873 year: 2010 end-page: 1882 ident: b0125 article-title: An ovine transgenic Huntington’s disease model publication-title: Hum Mol Genet – volume: 8 start-page: 712 year: 2007 end-page: 723 ident: b0055 article-title: The effect of neurodegenerative diseases on the subventricular zone publication-title: Nat Rev Neurosci – year: 2012 ident: b0040 article-title: Dynamics of olfactory and hippocampal neurogenesis in adult sheep publication-title: J Comp Neurol – volume: 96 start-page: 5263 year: 1999 end-page: 5267 ident: b0115 article-title: Hippocampal neurogenesis in adult Old World primates publication-title: Proc Natl Acad Sci U S A – volume: 80 start-page: 1146 year: 2009 end-page: 1151 ident: b0120 article-title: Rapid induction of cell proliferation in the adult female ungulate brain ( publication-title: Biol Reprod – volume: 20 start-page: 744 year: 2005 end-page: 751 ident: b0100 article-title: Reduced hippocampal neurogenesis in R6/2 transgenic Huntington’s disease mice publication-title: Neurobiol Dis – volume: 58 start-page: 940 year: 2010 end-page: 949 ident: b0185 article-title: Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients publication-title: Neuropharmacology – volume: 72 start-page: 990 year: 2012 end-page: 1005 ident: b0065 article-title: Neurogenesis and progenitor cells in the adult human brain: A comparison between hippocampal and subventricular progenitor proliferation publication-title: Dev Neurobiol – volume: 4 start-page: 555 year: 1998 end-page: 557 ident: b0140 article-title: Closer to neurogenesis in adult humans publication-title: Nat Med – volume: 107 start-page: 11104 year: 2010 ident: b0225 article-title: Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates publication-title: Proc Natl Acad Sci U S A – volume: 444 start-page: 532 year: 2006 end-page: 533 ident: b0200 article-title: The bitterest pill publication-title: Nature – volume: 11 start-page: 514 year: 2006 end-page: 522 ident: b0210 article-title: Neural stem cell proliferation is decreased in schizophrenia, but not in depression publication-title: Mol Psychiatry – volume: 44 start-page: 559 year: 1985 ident: b0230 article-title: Neuropathological classification of Huntington’s disease publication-title: J Neuropathol Exp Neurol – volume: 12 start-page: 688 year: 2007 end-page: 699 ident: b0215 article-title: The application of human embryonic stem cell technologies to drug discovery publication-title: Drug Discov Today – reference: Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Academic Press. – volume: 4 start-page: 1313 year: 1998 end-page: 1317 ident: b0085 article-title: Neurogenesis in the adult human hippocampus publication-title: Nat Med – volume: 100 start-page: 9023 year: 2003 ident: b0045 article-title: Increased cell proliferation and neurogenesis in the adult human Huntington’s disease brain publication-title: Proc Natl Acad Sci U S A – volume: 5 start-page: 545 year: 2006 end-page: 558 ident: b0205 article-title: The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus publication-title: Aging Cell – volume: 13 start-page: 690 year: 2010 end-page: 699 ident: b0245 article-title: OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling publication-title: Nat Neurosci – volume: 108 start-page: 10326 year: 2011 end-page: 10331 ident: b0150 article-title: Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months publication-title: Proc Natl Acad Sci U S A – volume: 25 start-page: 333 year: 2004 end-page: 340 ident: b0025 article-title: Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice publication-title: Neurobiol Aging – volume: 23 start-page: 1829 year: 2006 end-page: 1838 ident: b0170 article-title: Neurogenesis in the R6/1 transgenic mouse model of Huntington’s disease: effects of environmental enrichment publication-title: Eur J Neurosci – volume: 100 start-page: 9023 year: 2003 ident: 10.1016/j.neuroscience.2013.04.006_b0045 article-title: Increased cell proliferation and neurogenesis in the adult human Huntington’s disease brain publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1532244100 – volume: 4 start-page: 1313 year: 1998 ident: 10.1016/j.neuroscience.2013.04.006_b0085 article-title: Neurogenesis in the adult human hippocampus publication-title: Nat Med doi: 10.1038/3305 – volume: 2 start-page: 260 year: 1999 ident: 10.1016/j.neuroscience.2013.04.006_b0110 article-title: Learning enhances adult neurogenesis in the hippocampal formation publication-title: Nat Neurosci doi: 10.1038/6365 – volume: 5 start-page: 545 year: 2006 ident: 10.1016/j.neuroscience.2013.04.006_b0205 article-title: The window and mechanisms of major age-related decline in the production of new neurons within the dentate gyrus of the hippocampus publication-title: Aging Cell doi: 10.1111/j.1474-9726.2006.00243.x – volume: 21 start-page: 1534 year: 2011 ident: 10.1016/j.neuroscience.2013.04.006_b0255 article-title: Identification and characterization of neuroblasts in the subventricular zone and rostral migratory stream of the adult human brain publication-title: Cell Res doi: 10.1038/cr.2011.83 – volume: 80 start-page: 1146 year: 2009 ident: 10.1016/j.neuroscience.2013.04.006_b0120 article-title: Rapid induction of cell proliferation in the adult female ungulate brain (Ovis aries) associated with activation of the reproductive axis by exposure to unfamiliar males publication-title: Biol Reprod doi: 10.1095/biolreprod.108.075341 – volume: 491 start-page: 31 year: 2012 ident: 10.1016/j.neuroscience.2013.04.006_b0020 article-title: There’s more to life than rats and flies publication-title: Nature doi: 10.1038/491031a – volume: 97 start-page: 703 year: 1999 ident: 10.1016/j.neuroscience.2013.04.006_b0080 article-title: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain publication-title: Cell doi: 10.1016/S0092-8674(00)80783-7 – volume: 173 start-page: 76 year: 2011 ident: 10.1016/j.neuroscience.2013.04.006_b0240 article-title: Neurogenesis in the R6/2 mouse model of Huntington’s disease is impaired at the level of NeuroD1 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2010.08.022 – volume: 19 start-page: 1873 year: 2010 ident: 10.1016/j.neuroscience.2013.04.006_b0125 article-title: An ovine transgenic Huntington’s disease model publication-title: Hum Mol Genet doi: 10.1093/hmg/ddq063 – volume: 108 start-page: 10326 year: 2011 ident: 10.1016/j.neuroscience.2013.04.006_b0150 article-title: Maturation time of new granule cells in the dentate gyrus of adult macaque monkeys exceeds six months publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1017099108 – volume: 16 start-page: 1917 year: 2002 ident: 10.1016/j.neuroscience.2013.04.006_b0010 article-title: The rostral migratory stream in adult squirrel monkeys: contribution of new neurons to the olfactory tubercle and involvement of the antiapoptotic protein Bcl-2 publication-title: Eur J Neurosci doi: 10.1046/j.1460-9568.2002.02263.x – volume: 151 start-page: 159 year: 2004 ident: 10.1016/j.neuroscience.2013.04.006_b0005 article-title: Evidence of newly generated neurons in the human olfactory bulb publication-title: Dev Brain Res doi: 10.1016/j.devbrainres.2004.03.021 – volume: 132 start-page: 777 year: 2005 ident: 10.1016/j.neuroscience.2013.04.006_b0050 article-title: The distribution of progenitor cells in the subependymal layer of the lateral ventricle in the normal and Huntington’s disease human brain publication-title: Neuroscience doi: 10.1016/j.neuroscience.2004.12.051 – volume: 41 start-page: 249 year: 2011 ident: 10.1016/j.neuroscience.2013.04.006_b0220 article-title: Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2010.09.012 – volume: 58 start-page: 940 year: 2010 ident: 10.1016/j.neuroscience.2013.04.006_b0185 article-title: Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients publication-title: Neuropharmacology doi: 10.1016/j.neuropharm.2010.01.012 – volume: 199 start-page: 577 year: 2011 ident: 10.1016/j.neuroscience.2013.04.006_b0180 article-title: No change in progenitor cell proliferation in the hippocampus in Huntington’s disease publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.09.010 – volume: 96 start-page: 5768 year: 1999 ident: 10.1016/j.neuroscience.2013.04.006_b0155 article-title: Continuation of neurogenesis in the hippocampus of the adult macaque monkey publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.96.10.5768 – volume: 444 start-page: 532 year: 2006 ident: 10.1016/j.neuroscience.2013.04.006_b0200 article-title: The bitterest pill publication-title: Nature doi: 10.1038/444532a – ident: 10.1016/j.neuroscience.2013.04.006_b0250 – volume: 514 start-page: 533 year: 2009 ident: 10.1016/j.neuroscience.2013.04.006_b0105 article-title: Ultrastructure of the subventricular zone in Macaca fascicularis and evidence of a mouse-like migratory stream publication-title: J Comp Neurol doi: 10.1002/cne.22026 – volume: 20 start-page: 744 year: 2005 ident: 10.1016/j.neuroscience.2013.04.006_b0100 article-title: Reduced hippocampal neurogenesis in R6/2 transgenic Huntington’s disease mice publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2005.05.006 – volume: 72 start-page: 990 year: 2012 ident: 10.1016/j.neuroscience.2013.04.006_b0065 article-title: Neurogenesis and progenitor cells in the adult human brain: A comparison between hippocampal and subventricular progenitor proliferation publication-title: Dev Neurobiol doi: 10.1002/dneu.22028 – volume: 44 start-page: 559 year: 1985 ident: 10.1016/j.neuroscience.2013.04.006_b0230 article-title: Neuropathological classification of Huntington’s disease publication-title: J Neuropathol Exp Neurol doi: 10.1097/00005072-198511000-00003 – volume: 15 start-page: 811 year: 2004 ident: 10.1016/j.neuroscience.2013.04.006_b0165 article-title: Decreased hippocampal cell proliferation in R6/1 Huntington’s mice publication-title: Neuroreport doi: 10.1097/00001756-200404090-00014 – volume: 28 start-page: 1562 year: 2003 ident: 10.1016/j.neuroscience.2013.04.006_b0190 article-title: Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment publication-title: Neuropsychopharmacology doi: 10.1038/sj.npp.1300234 – volume: 34 start-page: 2376 year: 2009 ident: 10.1016/j.neuroscience.2013.04.006_b0015 article-title: Antidepressants increase neural progenitor cells in the human hippocampus publication-title: Neuropsychopharmacology doi: 10.1038/npp.2009.75 – volume: 175 start-page: 310 year: 2008 ident: 10.1016/j.neuroscience.2013.04.006_b0030 article-title: Adult mammalian neurogenesis and the New Zealand white rabbit publication-title: Vet J doi: 10.1016/j.tvjl.2007.01.023 – volume: 13 start-page: 690 year: 2010 ident: 10.1016/j.neuroscience.2013.04.006_b0245 article-title: OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling publication-title: Nat Neurosci doi: 10.1038/nn.2553 – volume: 96 start-page: 5263 year: 1999 ident: 10.1016/j.neuroscience.2013.04.006_b0115 article-title: Hippocampal neurogenesis in adult Old World primates publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.96.9.5263 – volume: 8 start-page: 712 year: 2007 ident: 10.1016/j.neuroscience.2013.04.006_b0055 article-title: The effect of neurodegenerative diseases on the subventricular zone publication-title: Nat Rev Neurosci doi: 10.1038/nrn2216 – volume: 25 start-page: 333 year: 2004 ident: 10.1016/j.neuroscience.2013.04.006_b0025 article-title: Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice publication-title: Neurobiol Aging doi: 10.1016/S0197-4580(03)00083-6 – volume: 17 start-page: 5046 year: 1997 ident: 10.1016/j.neuroscience.2013.04.006_b0075 article-title: Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain publication-title: J Neurosci doi: 10.1523/JNEUROSCI.17-13-05046.1997 – volume: 101 start-page: 343 year: 2004 ident: 10.1016/j.neuroscience.2013.04.006_b0135 article-title: Increased hippocampal neurogenesis in Alzheimer’s disease publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.2634794100 – volume: 7 start-page: e36016 year: 2012 ident: 10.1016/j.neuroscience.2013.04.006_b0195 article-title: Identification of the rostral migratory stream in the canine and feline brain publication-title: PLoS One doi: 10.1371/journal.pone.0036016 – volume: 315 start-page: 1243 year: 2007 ident: 10.1016/j.neuroscience.2013.04.006_b0060 article-title: Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension publication-title: Science doi: 10.1126/science.1136281 – volume: 98 start-page: 4710 year: 2001 ident: 10.1016/j.neuroscience.2013.04.006_b0130 article-title: Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.081011098 – volume: 69 start-page: 297 year: 2001 ident: 10.1016/j.neuroscience.2013.04.006_b0070 article-title: Risks in new drug development: approval success rates for investigational drugs publication-title: Clin Pharmacol Ther doi: 10.1067/mcp.2001.115446 – volume: 4 start-page: 555 year: 1998 ident: 10.1016/j.neuroscience.2013.04.006_b0140 article-title: Closer to neurogenesis in adult humans publication-title: Nat Med doi: 10.1038/nm0598-555 – volume: 271 start-page: 978 year: 1996 ident: 10.1016/j.neuroscience.2013.04.006_b0175 article-title: Chain migration of neuronal precursors publication-title: Science doi: 10.1126/science.271.5251.978 – volume: 12 start-page: 688 year: 2007 ident: 10.1016/j.neuroscience.2013.04.006_b0215 article-title: The application of human embryonic stem cell technologies to drug discovery publication-title: Drug Discov Today doi: 10.1016/j.drudis.2007.07.005 – volume: 11 start-page: 514 year: 2006 ident: 10.1016/j.neuroscience.2013.04.006_b0210 article-title: Neural stem cell proliferation is decreased in schizophrenia, but not in depression publication-title: Mol Psychiatry doi: 10.1038/sj.mp.4001791 – volume: 386 start-page: 493 year: 1997 ident: 10.1016/j.neuroscience.2013.04.006_b0145 article-title: More hippocampal neurons in adult mice living in an enriched environment publication-title: Nature doi: 10.1038/386493a0 – volume: 98 start-page: 4752 year: 2001 ident: 10.1016/j.neuroscience.2013.04.006_b0160 article-title: The generation, migration, and differentiation of olfactory neurons in the adult primate brain publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.081074998 – volume: 23 start-page: 1829 year: 2006 ident: 10.1016/j.neuroscience.2013.04.006_b0170 article-title: Neurogenesis in the R6/1 transgenic mouse model of Huntington’s disease: effects of environmental enrichment publication-title: Eur J Neurosci doi: 10.1111/j.1460-9568.2006.04715.x – year: 2012 ident: 10.1016/j.neuroscience.2013.04.006_b0040 article-title: Dynamics of olfactory and hippocampal neurogenesis in adult sheep publication-title: J Comp Neurol – volume: 107 start-page: 11104 year: 2010 ident: 10.1016/j.neuroscience.2013.04.006_b0225 article-title: Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0912810107 – volume: 58 start-page: 737 year: 2010 ident: 10.1016/j.neuroscience.2013.04.006_b0035 article-title: Evidence for cell proliferation in the sheep brain and its down-regulation by parturition and interactions with the young publication-title: Horm Behav doi: 10.1016/j.yhbeh.2010.07.006
SSID	ssj0000543
Score	2.2131233
Snippet	•We studied adult sheep neurogenic niches after administering BrdU.•Progenitor cell distribution in the sheep subventricular zone is similar to humans.•The... Highlights • We studied adult sheep neurogenic niches after administering BrdU. • Progenitor cell distribution in the sheep subventricular zone is similar to... Progenitor cell proliferation is ubiquitous in the subventricular zone (SVZ) and subgranular zone (SGZ) of adult mammalian brains, however, the abundance and...
SourceID	proquest pubmed pascalfrancis crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	173
SubjectTerms	Age Factors animal model Animals Biological and medical sciences Brain - cytology Brain - growth & development brain plasticity Cell Proliferation Female Fundamental and applied biological sciences. Psychology germinal niche Neurogenesis Neurology Sheep Stem Cells - cytology Stem Cells - physiology transgenic sheep Vertebrates: nervous system and sense organs
Title	Neurogenesis and progenitor cell distribution in the subgranular zone and subventricular zone of the adult sheep brain
URI	https://www.clinicalkey.com/#!/content/1-s2.0-S0306452213003242 https://www.clinicalkey.es/playcontent/1-s2.0-S0306452213003242 https://dx.doi.org/10.1016/j.neuroscience.2013.04.006 https://www.ncbi.nlm.nih.gov/pubmed/23587842 https://www.proquest.com/docview/1357496945
Volume	244
WOSCitedRecordID	wos000320347800015&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
journalDatabaseRights	– providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1873-7544 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000543 issn: 0306-4522 databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier
link	http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLa6jQckhIBxKZfKSIiXKlESx7EtxENBGzCNCsFAfbNy8-g00qppq8Ev4edybOc2RqUixEvUHPUkTs4Xn2P7-DsIPRNJlscKhqksynInTBPfEYlQDhEhY1nue4rGptgEG4_5ZCI-9Ho_670w63NWFPziQsz_q6lBBsbWW2f_wtzNRUEAv8HocASzw3Erwxu6jVPdhU3LigZAn8KXuxjqaXq9JtOUuarTHMtVcgpey-Sk_pgVdk0BhDob0kwR1vIqpcDQdgzLr3k-Hya6ykQ3yB23HJkNbI7tGtIX99BtIBOv7JrHR_fYfd-IX5mdQma-oJG9qcLskXvkducpdM0I7nhRO3lWb6Bps5XMpi0vcjSpu3VHtg_mjDial6_bSQfVqe1mfVv-pPLYvnXZV5yBnZc4czvMoJoY1SeG3Nb7jYHb-PRPukG6PXqVT8eaO2gvYFRAl783encwOWq9PLUZmfUD1IS2Jndw0x03BT835nEJn6SytVQ2D3ZM0HNyC92sRit4ZFF2G_Xy4g7aHxXxcvbtO36OTf6wWZjZR-su8DDgB7fAwxp4uAs8PC0wAAl3gIc1wIziZeBZ-UyZ_xvgYQM8bIB3F30-PDh5_dapqno4KQ3CpcMhyMyijDCeEy-G0bLyPBVx4cfcC1KmSMKZ5rUjgiiIrsI0CLgfsYymBJwRV-Qe2i3gvg8QzmiSZFlGWQ6jYpWAqwlEygOaRzAMD5nqI1G_bplWlPe68sq5rHMbz2TXVFKbSnqhBFP1EWl055b4ZSutF7VVZb21GZyxBEhupc3-pJ2XVfdSSl-WgfTkFZj20ctGs7qwDYm3vvPgEgSbRw5YSLVj76OnNSYlOCCNmrjIZytoEqEsFJEIaR_dt2BttQnljIfBw39s3iN0ve1SHqPd5WKVP0HX0vVyWi4GaIdN-KD6QH8BrAISkw
linkProvider	Elsevier
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Neurogenesis+and+progenitor+cell+distribution+in+the+subgranular+zone+and+subventricular+zone+of+the+adult+sheep+brain&rft.jtitle=Neuroscience&rft.au=Low%2C+V.F.&rft.au=Faull%2C+R.L.M.&rft.au=Bennet%2C+L.&rft.au=Gunn%2C+A.J.&rft.date=2013-08-06&rft.pub=Elsevier+Ltd&rft.issn=0306-4522&rft.eissn=1873-7544&rft.volume=244&rft.spage=173&rft.epage=187&rft_id=info:doi/10.1016%2Fj.neuroscience.2013.04.006&rft.externalDocID=S0306452213003242
thumbnail_m	http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F03064522%2FS0306452213X00144%2Fcov150h.gif