Cellular reprogramming by transcription factor engineering

Summary diagram showing the modulation of gene expression by designer transcription factors generated by different platforms. TALE: Transcription activator-like Effector; ZFE: Zinc Finger Effector; CRISPRE: Clustered Regularly Interspaced Short Palindromic Repeats Effector. Recent researches have id...

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Veröffentlicht in:Current opinion in genetics & development Jg. 28; S. 1 - 9
Hauptverfasser: Tsang, Jason CH, Gao, Xuefei, Lu, Liming, Liu, Pentao
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.10.2014
Schlagworte:
Animals
Cell Differentiation
Cellular Reprogramming
Genetic Engineering - methods
Humans
Medical Education
Pluripotent Stem Cells - cytology
Transcription Factors - genetics
Transcription Factors - metabolism
ISSN:0959-437X, 1879-0380, 1879-0380
Online-Zugang:Volltext
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Zusammenfassung:Summary diagram showing the modulation of gene expression by designer transcription factors generated by different platforms. TALE: Transcription activator-like Effector; ZFE: Zinc Finger Effector; CRISPRE: Clustered Regularly Interspaced Short Palindromic Repeats Effector. Recent researches have identified multiple transcription factors as permissible reprogramming factors to pluripotency and lineage switching. The current standard strategy by ectopic factor overexpression however has intrinsic limitations in studying the reprogramming mechanism. There is a growing interest in engineering novel chimeric reprogramming factors and applying designer transcription factors technology to improve reprogramming efficiency and dissect the process of endogenous pluripotency network reactivation. Here, we provide a concise review on the latest progress in studying cellular reprogramming by transcription factor engineering.
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ISSN:0959-437X
1879-0380
1879-0380
DOI:10.1016/j.gde.2014.07.001