Mushroom intake and depression: A population-based study using data from the US National Health and Nutrition Examination Survey (NHANES), 2005–2016

•Association between mushroom intake and depression was examined using NHANES.•The overall prevalence of depression was 5.9%.•Participants with mushroom consumption had lower odds of having depression. Mushrooms contain numerous bioactive compounds that may be associated with reduced anxiety includi...

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Bibliographic Details
Published in:Journal of affective disorders Vol. 294; pp. 686 - 692
Main Authors: Ba, Djibril M., Gao, Xiang, Al-Shaar, Laila, Muscat, Joshua E., Chinchilli, Vernon M., Beelman, Robert B., Richie, John P.
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.11.2021
Subjects:
Adult
Agaricales
Cross-Sectional Studies
Depression
Depression - epidemiology
Diet
Epidemiology
Humans
Middle Aged
Mushroom
NHANES
Nutrition Surveys
Patient Health Questionnaire
Psychiatric/Mental Health
United States - epidemiology
United States
NDI
Diet
FNDDS
Mushroom
FCID
Depression
NHANES
PHQ-9
NGF
Epidemiology
FNDDS: Food and Nutrient Databases for Dietary Studies
FCID: Food Commodity Intake Database
NDI: National Death Index
Mushroom, depression, diet, epidemiology, NHANES Abbreviations: PHQ-9: Patient Health Questionnaire
NHANES: National Health and Nutrition Examination Survey
NGF: Nerve growth factor
ISSN:0165-0327, 1573-2517, 1573-2517
Online Access:Get full text
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Summary:•Association between mushroom intake and depression was examined using NHANES.•The overall prevalence of depression was 5.9%.•Participants with mushroom consumption had lower odds of having depression. Mushrooms contain numerous bioactive compounds that may be associated with reduced anxiety including vitamin B12, nerve growth factor, antioxidants, and anti-inflammatory agents. We hypothesized that mushroom consumption is associated with a lower risk of depression in American adults. Data from the National Health and Nutrition Examination Survey 2005–2016 was used. Up to two days of 24 h dietary recall were analyzed to assess mushroom intake frequency. Depression was measured using the Patient Health Questionnaire (PHQ-9, score ≥ 10). We used multivariable logistic regression models, adjusting for potential confounding factors. Among 24,699 participants (mean (SE) age: 45.5 (0.3) years), the weighted prevalence of depression was 5.9%. Mushrooms were consumed by 5.2% of participants. Compared with the lowest tertile of mushroom intake, participants in the middle tertile (median intake = 4.9 g/d, number of cases = 16) had lower odds of depression (adjusted OR = 0.31; 95% confidence interval [CI] 0.16, 0.60) while those in the highest tertile did not differ (median intake = 19.6 g/d, adjusted OR = 0.91; 95% CI: 0.47, 1.78, number of cases = 22) (P-trend = 0.42). Cross-sectional data and lack of information on specific types of mushrooms consumed. Mushroom consumers had a lower odd of depression. However, we did not observe a dose-response relationship.
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ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2021.07.080