Therapeutic Efficacy of Adipose Tissue-Derived Components in Neuropathic Pain: A Systematic Review

Background: Neuropathic pain results from a defect in the somatosensory nervous system caused by a diversity of etiologies. The effect of current treat-ment with analgesics and surgery is limited. Studies report the therapeutic use of adipose tissue-derived components to treat neuropathic pain as a...

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Published in:Bioengineering (Basel) Vol. 11; no. 10; p. 992
Main Authors: Claessens, Anouk A. E., Vriend, Linda, Ovadja, Zachri N., Harmsen, Martin C., van Dongen, Joris. A., Coert, J. Henk
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 01.10.2024
MDPI
Subjects:
adipose stromal cells
Adipose tissue
Adipose tissues
Analgesics
autologous fat grafting
Body fat
Care and treatment
Clinical trials
Drug therapy
Effectiveness
Females
Grafting
Grafts
Health services
Mastectomy
Nervous system
neuropathic pain
Neuropathy
Pain
Patients
Physiological aspects
Quality of life
Reconstructive surgery
stromal vascular fraction
Systematic Review
Netherlands
neuropathic pain
adipose stromal cells
autologous fat grafting
stromal vascular fraction
ISSN:2306-5354, 2306-5354
Online Access:Get full text
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Summary:Background: Neuropathic pain results from a defect in the somatosensory nervous system caused by a diversity of etiologies. The effect of current treat-ment with analgesics and surgery is limited. Studies report the therapeutic use of adipose tissue-derived components to treat neuropathic pain as a new treatment modality. Objective: The aim of this systematic review was to investigate the therapeutic clinical efficacy of adipose tissue-derived components on neuro-pathic pain. Methods: PubMed, Medline, Cochrane and Embase databases were searched until August 2023. Clinical studies assessing neuropathic pain after autologous fat grafting or the therapeutic use of adipose tissue-derived com-ponents were included. The outcomes of interest were neuropathic pain and quality of life. Results: In total, 433 studies were identified, of which 109 dupli-cates were removed, 324 abstracts were screened and 314 articles were excluded. In total, ten studies were included for comparison. Fat grafting and cellular stromal vascular fraction were used as treatments. Fat grafting indications were post-mastectomy pain syndrome, neuromas, post-herpetic neuropathy, neuro-pathic scar pain and trigeminal neuropathic pain. In seven studies, neuropathic pain levels decreased, and overall, quality of life did not improve. Conclusions: The therapeutic efficacy of adipose tissue-derived components in the treatment of neuropathic pain remains unclear due to the few performed clinical trials with small sample sizes for various indications. Larger and properly designed (randomized) controlled trials are required.
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These authors contributed equally to this work.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering11100992