Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations

Next generation sequencing (NGS)-based tumor profiling identified an overwhelming number of uncharacterized somatic mutations, also known as variants of unknown significance (VUS). The therapeutic significance of mutations outside mutational hotspots, consisting of >50 types, in nonsmall cell lun...

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Vydané v:	Proceedings of the National Academy of Sciences - PNAS Ročník 116; číslo 20; s. 10025
Hlavní autori:	Ikemura, Shinnosuke, Yasuda, Hiroyuki, Matsumoto, Shingo, Kamada, Mayumi, Hamamoto, Junko, Masuzawa, Keita, Kobayashi, Keigo, Manabe, Tadashi, Arai, Daisuke, Nakachi, Ichiro, Kawada, Ichiro, Ishioka, Kota, Nakamura, Morio, Namkoong, Ho, Naoki, Katsuhiko, Ono, Fumie, Araki, Mitsugu, Kanada, Ryo, Ma, Biao, Hayashi, Yuichiro, Mimaki, Sachiyo, Yoh, Kiyotaka, Kobayashi, Susumu S, Kohno, Takashi, Okuno, Yasushi, Goto, Koichi, Tsuchihara, Katsuya, Soejima, Kenzo
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 14.05.2019
Predmet:	Acrylamides - therapeutic use Adenocarcinoma - drug therapy Aniline Compounds - therapeutic use Carcinoma, Non-Small-Cell Lung - genetics Genes, erbB-1 Humans Lung Neoplasms - drug therapy Lung Neoplasms - genetics Middle Aged Molecular Dynamics Simulation Mutation Pharmacogenomic Testing Prospective Studies Protein-Tyrosine Kinases - antagonists & inhibitors rare EGFR mutation mutation diversity in silico prediction model nonsmall cell lung cancer osimertinib
ISSN:	1091-6490, 1091-6490
On-line prístup:	Zistit podrobnosti o prístupe
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