Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research

The recently developed new genome-editing technologies, such as the CRISPR/Cas system, have opened the door for generating genetically modified nonhuman primate (NHP) models for basic neuroscience and brain disorders research. The complex circuit formation and experience-dependent refinement of the...

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Bibliographic Details
Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 39; p. 24022
Main Authors:	Feng, Guoping, Jensen, Frances E, Greely, Henry T, Okano, Hideyuki, Treue, Stefan, Roberts, Angela C, Fox, James G, Caddick, Sarah, Poo, Mu-Ming, Newsome, William T, Morrison, John H
Format:	Journal Article
Language:	English
Published:	United States 29.09.2020
Subjects:	Animal Experimentation - ethics Animals Disease Models, Animal Mental Disorders - genetics Mental Disorders - physiopathology Nervous System Diseases - genetics Nervous System Diseases - physiopathology Neurosciences - ethics Neurosciences - methods Primates - genetics Primates - physiology CRISPR nonhuman primate primates disease models genetic engineering
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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