Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study

Introduction Influenza accounts for 5 to 10% of community-acquired pneumonias and is a major cause of mortality. Sterile and bacterial lung injuries are associated with procoagulant and inflammatory derangements in the lungs. Activated protein C (APC) is an anticoagulant with anti-inflammatory prope...

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Bibliographic Details
Published in:	Critical care (London, England) Vol. 14; no. 2; p. R65
Main Authors:	Schouten, Marcel, van der Sluijs, Koenraad F, Gerlitz, Bruce, Grinnell, Brian W, Roelofs, Joris JTH, Levi, Marcel M, van 't Veer, Cornelis, Poll, Tom van der
Format:	Journal Article
Language:	English
Published:	London BioMed Central 14.04.2010 BioMed Central Ltd National Library of Medicine - MEDLINE Abstracts
Subjects:	Animals Anticoagulants - antagonists & inhibitors Anticoagulants - metabolism Anticoagulants - therapeutic use Blood clotting disorders Blood Coagulation - drug effects Critical Care Medicine Dosage and administration Down-Regulation - genetics Drug therapy Emergency Medicine Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - pathogenicity Intensive Lung - drug effects Lung - immunology Male Medicine Medicine & Public Health Mice Mice, Inbred C57BL Models, Animal Orthomyxoviridae Infections - blood Orthomyxoviridae Infections - physiopathology Patient outcomes Protein C Protein C - antagonists & inhibitors Protein C - genetics Protein C - metabolism Protein C - therapeutic use Recombinant Proteins Respiratory intensive care Swine influenza Viral Load Netherlands Lung Homogenate Plasminogen Activator Activity Fibrin Degradation Product Influenza Lung Inflammation
ISSN:	1364-8535, 1466-609X, 1364-8535, 1466-609X
Online Access:	Get full text
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