Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation

Foxp3-expressing regulatory T cells (Tregs) can be generated in vitro by antigenic stimulation of conventional T cells (Tconvs) in the presence of TGF-β and IL-2. However, unlike Foxp3 naturally occurring Tregs, such in vitro induced Tregs (iTregs) are functionally unstable mainly because of incompl...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 22; p. 12258
Main Authors:	Mikami, Norihisa, Kawakami, Ryoji, Chen, Kelvin Y, Sugimoto, Atsushi, Ohkura, Naganari, Sakaguchi, Shimon
Format:	Journal Article
Language:	English
Published:	United States 02.06.2020
Subjects:	Treg-DR Foxp3 iTreg DNA hypomethylation Treg
ISSN:	1091-6490, 1091-6490
Online Access:	Get more information
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