Dysfunction of the Hypothalamic-Pituitary-Adrenal Axis in Opioid Dependent Subjects: Effects of Acute and Protracted Abstinence

Objectives: The function of the Hypothalamic-Pituitary-Adrenal (HPA) axis during opioid dependence has been inconsistent. We compared HPA axis measures between subjects during methadone stabilization and drug-free detoxification with healthy controls. Methods: Sixty heroin dependent patients receive...

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Bibliographic Details
Published in:	The American journal of drug and alcohol abuse Vol. 34; no. 6; pp. 760 - 768
Main Authors:	Zhang, Guo-Fu, Ren, Yan-Ping, Sheng, Li-Xia, Chi, Yong, Du, Wan-Jun, Guo, Song, Jiang, Zuo-Ning, Xiao, Le, Luo, Xiao-Nian, Tang, Yi-Lang, Smith, Alicia K., Liu, Zhen-Qi, Zhang, Hong-Xi
Format:	Journal Article
Language:	English
Published:	Colchester Informa UK Ltd 01.01.2008 Taylor & Francis Taylor & Francis Ltd
Subjects:	ACTH Addictive behaviors Adrenocorticotropic Hormone - blood Adult Adult and adolescent clinical studies Benzodiazepines Benzodiazepines - therapeutic use Biological and medical sciences Clonidine Clonidine - therapeutic use Comparative analysis Corticotropin-Releasing Hormone - blood Cortisol CRH Detoxification Drug addiction Drug dependency Drug replacement therapy Drug therapy Female Heroin Heroin Dependence - physiopathology Heroin Dependence - rehabilitation Hormones HPA axis Humans Hydrocortisone - blood Hypothalamic-pituitary-adrenal axis Hypothalamo-Hypophyseal System - physiopathology Male Medical sciences Medical treatment Methadone Methadone - therapeutic use opioid dependence Opioids Patients Pituitary gland Pituitary-Adrenal System - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Serum Stabilization Substance Withdrawal Syndrome - physiopathology Treatment Young Adult Hypothalamohypophysoadrenal axis Corticotropin releasing factor ACTH Opiates Cortisol HPA axis Hydrocortisone Glucocorticoid Dependence Hormone releasing factor Human Corticosteroid Drug addiction Steroid hormone Acute Substance abuse Abstinence Hypothalamic hormone Adrenocorticotropic hormone Adenohypophyseal hormone Addiction Dysfunction Adrenal hormone CRH opioid dependence
ISSN:	0095-2990, 1097-9891, 1097-9891
Online Access:	Get full text
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