In vitro toxicity evaluation of graphene oxide on A549 cells

Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas. However, little information of their toxicity and biocompatibility is available. Herein, we performed a comprehensive study on the toxicity of...

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Podrobná bibliografie
Vydáno v:	Toxicology letters Ročník 200; číslo 3; s. 201 - 210
Hlavní autoři:	Chang, Yanli, Yang, Sheng-Tao, Liu, Jia-Hui, Dong, Erya, Wang, Yanwen, Cao, Aoneng, Liu, Yuanfang, Wang, Haifang
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Shannon Elsevier Ireland Ltd 05.02.2011 Elsevier
Témata:	Apoptosis - drug effects Biocompatibility Biocompatible Materials - toxicity Biological and medical sciences biomedical materials Cell Death - drug effects cell growth Cell growth substrate Cell Line, Tumor Cell Membrane - drug effects Cell Membrane - ultrastructure Cell Proliferation - drug effects Cell Survival - drug effects cell viability cytotoxicity dose response Dose-Response Relationship, Drug electronics energy Epithelial Cells - drug effects Epithelial Cells - ultrastructure graphene Graphene oxide Graphite - toxicity Humans L-Lactate Dehydrogenase - metabolism Materials Testing Medical sciences Microscopy, Electron, Transmission mortality oxidative stress Oxides - pharmacology Reactive Oxygen Species - metabolism Size effect Toxicity Toxicology Cell growth substrate Biocompatibility Graphene oxide Toxicity Size effect Human Cell proliferation Evaluation Lung Oxides Respiratory system In vitro Substrate Cell line
ISSN:	0378-4274, 1879-3169, 1879-3169
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Popis
Shrnutí:	Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas. However, little information of their toxicity and biocompatibility is available. Herein, we performed a comprehensive study on the toxicity of graphene oxide (GO) by examining the influences of GO on the morphology, viability, mortality and membrane integrity of A549 cells. The results suggest that GO does not enter A549 cell and has no obvious cytotoxicity. But GO can cause a dose-dependent oxidative stress in cell and induce a slight loss of cell viability at high concentration. These effects are dose and size related, and should be considered in the development of bio-applications of GO. Overall, GO is a pretty safe material at cellular level, which is confirmed by the favorable cell growth on GO film.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-4274 1879-3169 1879-3169
DOI:	10.1016/j.toxlet.2010.11.016