In vitro toxicity evaluation of graphene oxide on A549 cells

Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas. However, little information of their toxicity and biocompatibility is available. Herein, we performed a comprehensive study on the toxicity of...

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Bibliographic Details
Published in:Toxicology letters Vol. 200; no. 3; pp. 201 - 210
Main Authors: Chang, Yanli, Yang, Sheng-Tao, Liu, Jia-Hui, Dong, Erya, Wang, Yanwen, Cao, Aoneng, Liu, Yuanfang, Wang, Haifang
Format: Journal Article
Language:English
Published: Shannon Elsevier Ireland Ltd 05.02.2011
Elsevier
Subjects:
Apoptosis - drug effects
Biocompatibility
Biocompatible Materials - toxicity
Biological and medical sciences
biomedical materials
Cell Death - drug effects
cell growth
Cell growth substrate
Cell Line, Tumor
Cell Membrane - drug effects
Cell Membrane - ultrastructure
Cell Proliferation - drug effects
Cell Survival - drug effects
cell viability
cytotoxicity
dose response
Dose-Response Relationship, Drug
electronics
energy
Epithelial Cells - drug effects
Epithelial Cells - ultrastructure
graphene
Graphene oxide
Graphite - toxicity
Humans
L-Lactate Dehydrogenase - metabolism
Materials Testing
Medical sciences
Microscopy, Electron, Transmission
mortality
oxidative stress
Oxides - pharmacology
Reactive Oxygen Species - metabolism
Size effect
Toxicity
Toxicology
Cell growth substrate
Biocompatibility
Graphene oxide
Toxicity
Size effect
Human
Cell proliferation
Evaluation
Lung
Oxides
Respiratory system
In vitro
Substrate
Cell line
ISSN:0378-4274, 1879-3169, 1879-3169
Online Access:Get full text
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Summary:Graphene and its derivatives have attracted great research interest for their potential applications in electronics, energy, materials and biomedical areas. However, little information of their toxicity and biocompatibility is available. Herein, we performed a comprehensive study on the toxicity of graphene oxide (GO) by examining the influences of GO on the morphology, viability, mortality and membrane integrity of A549 cells. The results suggest that GO does not enter A549 cell and has no obvious cytotoxicity. But GO can cause a dose-dependent oxidative stress in cell and induce a slight loss of cell viability at high concentration. These effects are dose and size related, and should be considered in the development of bio-applications of GO. Overall, GO is a pretty safe material at cellular level, which is confirmed by the favorable cell growth on GO film.
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ISSN:0378-4274
1879-3169
1879-3169
DOI:10.1016/j.toxlet.2010.11.016