The Role of the Microbiome in the Developmental Origins of Health and Disease

Although the prominent role of the microbiome in human health has been established, the early-life microbiome is now being recognized as a major influence on long-term human health and development. Variations in the composition and functional potential of the early-life microbiome are the result of...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Pediatrics (Evanston) Ročník 141; číslo 4
Hlavní autoři: Stiemsma, Leah T, Michels, Karin B
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.04.2018
Témata:
Asthma - microbiology
Asthma - prevention & control
Breast Feeding - trends
Female
Gastrointestinal Microbiome - physiology
Health Status
Humans
Infant, Newborn
Maternal-Fetal Exchange - physiology
Neurodevelopmental Disorders - microbiology
Neurodevelopmental Disorders - prevention & control
Pregnancy
Primary Prevention - methods
Primary Prevention - trends
ISSN:1098-4275, 1098-4275
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Although the prominent role of the microbiome in human health has been established, the early-life microbiome is now being recognized as a major influence on long-term human health and development. Variations in the composition and functional potential of the early-life microbiome are the result of lifestyle factors, such as mode of birth, breastfeeding, diet, and antibiotic usage. In addition, variations in the composition of the early-life microbiome have been associated with specific disease outcomes, such as asthma, obesity, and neurodevelopmental disorders. This points toward this bacterial consortium as a mediator between early lifestyle factors and health and disease. In addition, variations in the microbial intrauterine environment may predispose neonates to specific health outcomes later in life. A role of the microbiome in the Developmental Origins of Health and Disease is supported in this collective research. Highlighting the early-life critical window of susceptibility associated with microbiome development, we discuss infant microbial colonization, beginning with the maternal-to-fetal exchange of microbes in utero and up through the influence of breastfeeding in the first year of life. In addition, we review the available disease-specific evidence pointing toward the microbiome as a mechanistic mediator in the Developmental Origins of Health and Disease.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1098-4275
1098-4275
DOI:10.1542/peds.2017-2437