The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to...

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Vydáno v:Circulation research Ročník 128; číslo 2; s. 287
Hlavní autoři: Nayor, Matthew, Brown, Kemar J, Vasan, Ramachandran S
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 22.01.2021
Témata:
Animals
Atherosclerosis - diagnostic imaging
Atherosclerosis - genetics
Atherosclerosis - metabolism
Atherosclerosis - microbiology
Bacteria - metabolism
Biomarkers - metabolism
Disease Progression
Gastrointestinal Microbiome
Gene Expression Profiling
Heart Disease Risk Factors
Humans
Metabolome
Metabolomics
Molecular Imaging
Plaque, Atherosclerotic
Predictive Value of Tests
Proteome
Proteomics
Risk Assessment
Transcriptome
coronary artery disease
cardiovascular disease
proteomics
metabolome
ISSN:1524-4571, 1524-4571
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Popis
Shrnutí:Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1524-4571
1524-4571
DOI:10.1161/CIRCRESAHA.120.315890