The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk

Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to...

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Bibliographic Details
Published in:Circulation research Vol. 128; no. 2; p. 287
Main Authors: Nayor, Matthew, Brown, Kemar J, Vasan, Ramachandran S
Format: Journal Article
Language:English
Published: United States 22.01.2021
Subjects:
Animals
Atherosclerosis - diagnostic imaging
Atherosclerosis - genetics
Atherosclerosis - metabolism
Atherosclerosis - microbiology
Bacteria - metabolism
Biomarkers - metabolism
Disease Progression
Gastrointestinal Microbiome
Gene Expression Profiling
Heart Disease Risk Factors
Humans
Metabolome
Metabolomics
Molecular Imaging
Plaque, Atherosclerotic
Predictive Value of Tests
Proteome
Proteomics
Risk Assessment
Transcriptome
coronary artery disease
cardiovascular disease
proteomics
metabolome
ISSN:1524-4571, 1524-4571
Online Access:Get more information
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Summary:Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.
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ISSN:1524-4571
1524-4571
DOI:10.1161/CIRCRESAHA.120.315890