Entamoeba histolytica: Observations on metabolism based on the genome sequence

The sequencing of the genome of Entamoeba histolytica has allowed a reconstruction of its metabolic pathways, many of which are unusual for a eukaryote. Based on the genome sequence, it appears that amino acids may play a larger role than previously thought in energy metabolism, with roles in both A...

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Published in:	Experimental parasitology Vol. 110; no. 3; pp. 173 - 177
Main Authors:	Anderson, Iain J., Loftus, Brendan J.
Format:	Journal Article
Language:	English
Published:	San Diego, CA Elsevier Inc 01.07.2005 Elsevier
Subjects:	acetyl-coA synthase ACS adenosine triphosphate Amino acid degradation Amino Acids - metabolism Amoeba Animals ATP basic local alignment search tool Biological and medical sciences BLAST Carbohydrate Metabolism dCTP deoxycytidine triphosphate deoxythymidine monophosphate deoxyuridine monophosphate deoxyuridine triphosphate dTMP dUMP dUTP Energy Metabolism - genetics Entamoeba histolytica Entamoeba histolytica - enzymology Entamoeba histolytica - genetics Entamoeba histolytica - metabolism Entamoeba invadens Entamoeba moshkovskii Fundamental and applied biological sciences. Psychology Genome, Protozoan Glucose transport glycoside–pentoside–hexuronide:cation symporter GPH Humans Life cycle. Host-agent relationship. Pathogenesis Metabolism NAD nicotinamide adenine dinucleotide Nucleic Acids - metabolism PFOR Polyamine metabolism Polyamines - metabolism Protozoa Pyrimidine metabolism pyruvate:ferredoxin oxidoreductase TCA transport commission tricarboxylic acid dUTP Amino acid degradation Metabolism Glucose transport TC NAD Pyrimidine metabolism ACS TCA dCTP dUMP PFOR ATP BLAST dTMP GPH Amoeba Polyamine metabolism Protozoa Polyamine Lobosea Parasite Entamoeba histolytica Glucose Pyrimidine Aminoacid Genome Transport Heterolobosea
ISSN:	0014-4894, 1090-2449
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Summary:	The sequencing of the genome of Entamoeba histolytica has allowed a reconstruction of its metabolic pathways, many of which are unusual for a eukaryote. Based on the genome sequence, it appears that amino acids may play a larger role than previously thought in energy metabolism, with roles in both ATP synthesis and NAD regeneration. Arginine decarboxylase may be involved in survival of E. histolytica during its passage through the stomach. The usual pyrimidine synthesis pathway is absent, but a partial pyrimidine degradation pathway could be part of a novel pyrimidine synthesis pathway. Ribonucleotide reductase was not found in the E. histolytica genome, but it was found in the close relatives Entamoeba invadens and Entamoeba moshkovskii, suggesting a recent loss from E. histolytica. The usual eukaryotic glucose transporters are not present, but members of a prokaryotic monosaccharide transporter family are present.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0014-4894 1090-2449
DOI:	10.1016/j.exppara.2005.03.010