LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS. Remarka...

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Bibliographic Details
Published in:	Cell metabolism Vol. 29; no. 4; p. 871
Main Authors:	Simon, Matthew, Van Meter, Michael, Ablaeva, Julia, Ke, Zhonghe, Gonzalez, Raul S, Taguchi, Taketo, De Cecco, Marco, Leonova, Katerina I, Kogan, Valeria, Helfand, Stephen L, Neretti, Nicola, Roichman, Asael, Cohen, Haim Y, Meer, Margarita V, Gladyshev, Vadim N, Antoch, Marina P, Gudkov, Andrei V, Sedivy, John M, Seluanov, Andrei, Gorbunova, Vera
Format:	Journal Article
Language:	English
Published:	United States 02.04.2019
Subjects:	Age Factors Animals Dideoxynucleotides - administration & dosage Dideoxynucleotides - pharmacology Female Inflammation - metabolism Male Mice Mice, Inbred Strains Mice, Knockout RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - metabolism Sirtuins - deficiency Sirtuins - metabolism Stavudine - administration & dosage Stavudine - pharmacology Thymine Nucleotides - administration & dosage Thymine Nucleotides - pharmacology Zidovudine - administration & dosage Zidovudine - analogs & derivatives Zidovudine - pharmacology longevity nucleotide reverse-transcriptase inhibitors SIRT6 aging retrotransposition
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
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