LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation

Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS. Remarka...

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Veröffentlicht in:	Cell metabolism Jg. 29; H. 4; S. 871
Hauptverfasser:	Simon, Matthew, Van Meter, Michael, Ablaeva, Julia, Ke, Zhonghe, Gonzalez, Raul S, Taguchi, Taketo, De Cecco, Marco, Leonova, Katerina I, Kogan, Valeria, Helfand, Stephen L, Neretti, Nicola, Roichman, Asael, Cohen, Haim Y, Meer, Margarita V, Gladyshev, Vadim N, Antoch, Marina P, Gudkov, Andrei V, Sedivy, John M, Seluanov, Andrei, Gorbunova, Vera
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.04.2019
Schlagworte:	Age Factors Animals Dideoxynucleotides - administration & dosage Dideoxynucleotides - pharmacology Female Inflammation - metabolism Male Mice Mice, Inbred Strains Mice, Knockout RNA-Binding Proteins - antagonists & inhibitors RNA-Binding Proteins - metabolism Sirtuins - deficiency Sirtuins - metabolism Stavudine - administration & dosage Stavudine - pharmacology Thymine Nucleotides - administration & dosage Thymine Nucleotides - pharmacology Zidovudine - administration & dosage Zidovudine - analogs & derivatives Zidovudine - pharmacology longevity nucleotide reverse-transcriptase inhibitors SIRT6 aging retrotransposition
ISSN:	1932-7420, 1932-7420
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