Accurate and Scalable Construction of Polygenic Scores in Large Biobank Data Sets

Accurate construction of polygenic scores (PGS) can enable early diagnosis of diseases and facilitate the development of personalized medicine. Accurate PGS construction requires prediction models that are both adaptive to different genetic architectures and scalable to biobank scale datasets with m...

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Vydané v:	American journal of human genetics Ročník 106; číslo 5; s. 679
Hlavní autori:	Yang, Sheng, Zhou, Xiang
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 07.05.2020
Predmet:	Bayes Theorem Databases, Factual - standards Datasets as Topic - standards Female Humans Linear Models Male Multifactorial Inheritance Polymorphism, Single Nucleotide Reproducibility of Results Sample Size United Kingdom White People - genetics United Kingdom complex traits deterministic Bayesian sparse linear mixed model UK Biobank polygenic risk score polygenic score
ISSN:	1537-6605, 1537-6605
On-line prístup:	Zistit podrobnosti o prístupe
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