Surviving as a Community: Antibiotic Tolerance and Persistence in Bacterial Biofilms

Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at...

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Bibliographic Details
Published in:Cell host & microbe Vol. 26; no. 1; p. 15
Main Authors: Yan, Jing, Bassler, Bonnie L
Format: Journal Article
Language:English
Published: United States 10.07.2019
Subjects:
Anti-Bacterial Agents - pharmacology
Bacteria - drug effects
Bacteria - growth & development
Biofilms - drug effects
Biofilms - growth & development
Drug Resistance, Bacterial
Drug Tolerance
Microbial Viability - drug effects
persistence
bacteria
antibiotic resistance
tolerance
biofilm
ISSN:1934-6069, 1934-6069
Online Access:Get more information
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Summary:Biofilms are surface-associated bacterial communities that play both beneficial and harmful roles in nature, medicine, and industry. Tolerant and persister cells are thought to underlie biofilm-related bacterial recurrence in medical and industrial contexts. Here, we review recent progress aimed at understanding the mechanical features that drive biofilm resilience and the biofilm formation process at single-cell resolution. We discuss findings regarding mechanisms underlying bacterial tolerance and persistence in biofilms and how these phenotypes are linked to antibiotic resistance. New strategies for combatting tolerance and persistence in biofilms and possible methods for biofilm eradication are highlighted to inspire future development.
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ISSN:1934-6069
1934-6069
DOI:10.1016/j.chom.2019.06.002