Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses

Dendritic cell (DC) activation by Toll-like receptor (TLR) agonists causes rapid glycolytic reprogramming that is required to meet the metabolic demands of their immune activation. Recent efforts in the field have identified an important role for extracellular glucose sourcing to support DC activati...

Full description

Saved in:

Bibliographic Details
Published in:	Cell metabolism Vol. 26; no. 3; p. 558
Main Authors:	Thwe, Phyu M, Pelgrom, Leonard R, Cooper, Rachel, Beauchamp, Saritha, Reisz, Julie A, D'Alessandro, Angelo, Everts, Bart, Amiel, Eyal
Format:	Journal Article
Language:	English
Published:	United States 05.09.2017
Subjects:	Animals Cell Differentiation - drug effects Cell Respiration - drug effects Cell Survival - drug effects Cellular Reprogramming - drug effects Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - ultrastructure Glycogen - metabolism Glycogen Phosphorylase - antagonists & inhibitors Glycogen Phosphorylase - metabolism Glycolysis - drug effects Hypoglycemia - pathology Lipopolysaccharides - pharmacology Mice Mitochondria - drug effects Mitochondria - metabolism dendritic cells glycogen glycogenolysis glycogen shunt glycolysis PYG
ISSN:	1932-7420, 1932-7420
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!