Cell-Intrinsic Glycogen Metabolism Supports Early Glycolytic Reprogramming Required for Dendritic Cell Immune Responses

Dendritic cell (DC) activation by Toll-like receptor (TLR) agonists causes rapid glycolytic reprogramming that is required to meet the metabolic demands of their immune activation. Recent efforts in the field have identified an important role for extracellular glucose sourcing to support DC activati...

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Veröffentlicht in:	Cell metabolism Jg. 26; H. 3; S. 558
Hauptverfasser:	Thwe, Phyu M, Pelgrom, Leonard R, Cooper, Rachel, Beauchamp, Saritha, Reisz, Julie A, D'Alessandro, Angelo, Everts, Bart, Amiel, Eyal
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 05.09.2017
Schlagworte:	Animals Cell Differentiation - drug effects Cell Respiration - drug effects Cell Survival - drug effects Cellular Reprogramming - drug effects Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - ultrastructure Glycogen - metabolism Glycogen Phosphorylase - antagonists & inhibitors Glycogen Phosphorylase - metabolism Glycolysis - drug effects Hypoglycemia - pathology Lipopolysaccharides - pharmacology Mice Mitochondria - drug effects Mitochondria - metabolism dendritic cells glycogen glycogenolysis glycogen shunt glycolysis PYG
ISSN:	1932-7420, 1932-7420
Online-Zugang:	Weitere Angaben
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