Epigenetic Mechanisms of Transmission of Metabolic Disease across Generations

Both human and animal studies indicate that environmental exposures experienced during early life can robustly influence risk for adult disease. Moreover, environmental exposures experienced by parents during either intrauterine or postnatal life can also influence the health of their offspring, thu...

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Bibliographic Details
Published in:Cell metabolism Vol. 25; no. 3; pp. 559 - 571
Main Authors: Sales, Vicencia Micheline, Ferguson-Smith, Anne C, Patti, Mary-Elizabeth
Format: Journal Article
Language:English
Published: United States 07.03.2017
Subjects:
Animals
Epigenesis, Genetic
Family Characteristics
Humans
Inheritance Patterns - genetics
Metabolic Diseases - genetics
Phenotype
Risk Factors
ISSN:1932-7420
Online Access:Get more information
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Summary:Both human and animal studies indicate that environmental exposures experienced during early life can robustly influence risk for adult disease. Moreover, environmental exposures experienced by parents during either intrauterine or postnatal life can also influence the health of their offspring, thus initiating a cycle of disease risk across generations. In this Perspective, we focus on epigenetic mechanisms in germ cells, including DNA methylation, histone modification, and non-coding RNAs, which collectively may provide a non-genetic molecular legacy of prior environmental exposures and influence transcriptional regulation, developmental trajectories, and adult disease risk in offspring.
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ISSN:1932-7420
DOI:10.1016/j.cmet.2017.02.016