An endosiRNA-Based Repression Mechanism Counteracts Transposon Activation during Global DNA Demethylation in Embryonic Stem Cells

Erasure of DNA methylation and repressive chromatin marks in the mammalian germline leads to risk of transcriptional activation of transposable elements (TEs). Here, we used mouse embryonic stem cells (ESCs) to identify an endosiRNA-based mechanism involved in suppression of TE transcription. In ESC...

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Bibliographic Details

Published in:	Cell stem cell Vol. 21; no. 5; p. 694
Main Authors:	Berrens, Rebecca V, Andrews, Simon, Spensberger, Dominik, Santos, Fátima, Dean, Wendy, Gould, Poppy, Sharif, Jafar, Olova, Nelly, Chandra, Tamir, Koseki, Haruhiko, von Meyenn, Ferdinand, Reik, Wolf
Format:	Journal Article
Language:	English
Published:	United States 02.11.2017
Subjects:	germ line repeats DNMT1 RNAi IAP elements endogenous retroviruses transposable element primordial germ cell small RNAs
ISSN:	1875-9777, 1875-9777
Online Access:	Get more information
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